<\/p>\n\n\n
Gonz\u00e1lez-Marr\u00f3n A, Mart\u00edn-S\u00e1nchez JC, Matilla-Santander N, Cartany\u00e0-Hueso \u00c0, Lid\u00f3n-Moyano C, Vidal C, Garc\u00eda M, Mart\u00ednez-S\u00e1nchez JM. <\/p>
Estimation of the adult population at high risk of developing lung cancer in the European Union<\/a>. Journal Article<\/span> <\/p>Cancer Epidemiol. <\/span>2018<\/span>;57<\/span>:140\u2013147<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30497060,\r\ntitle = {Estimation of the adult population at high risk of developing lung cancer in the European Union},\r\nauthor = {Gonz\u00e1lez-Marr\u00f3n A and Mart\u00edn-S\u00e1nchez JC and Matilla-Santander N and Cartany\u00e0-Hueso \u00c0 and Lid\u00f3n-Moyano C and Vidal C and Garc\u00eda M and Mart\u00ednez-S\u00e1nchez JM},\r\ndoi = {10.1016\/j.canep.2018.10.007},\r\nissn = {1877-783X},\r\nyear = {2018},\r\ndate = {2018-12-01},\r\njournal = {Cancer Epidemiol},\r\nvolume = {57},\r\npages = {140--147},\r\nabstract = {Background Lung cancer mortality accounts for over 266,000 deaths in the European Union (EU) every year, most of them attributed to smoking. The aim of this study was to estimate the prevalence of the adult population at high risk of developing lung cancer in the EU in 2014. Methods This is a cross-sectional study. We used data from the Special Eurobarometer 429 (n\u2009=\u200927,801). The fieldwork was conducted between November-December 2014. High risk of lung cancer was defined using the criteria of the National Lung Screening Trial (NLST) and the Dutch-Belgian Lung Cancer Screening Trial (NELSON). Results One out of ten smokers (11.6% of men and 9.6% of women) according to NLST criteria and one out of four smokers (24.6% of men and 22.4% of women) according to NELSON criteria are currently at high risk of lung cancer in the EU. According to both criteria, the prevalence of former smokers at high risk of lung cancer is under 10%. Conclusion Around 17 million citizens in the EU according to NLST criteria and 34 million according to NELSON criteria (around 4% and 8% of the adult population, respectively) are at high risk of developing lung cancer. Since the implementation of lung cancer screening programs still remains controversial, primary prevention activities should be encouraged.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Background Lung cancer mortality accounts for over 266,000 deaths in the European Union (EU) every year, most of them attributed to smoking. The aim of this study was to estimate the prevalence of the adult population at high risk of developing lung cancer in the EU in 2014. Methods This is a cross-sectional study. We used data from the Special Eurobarometer 429 (n\u2009=\u200927,801). The fieldwork was conducted between November-December 2014. High risk of lung cancer was defined using the criteria of the National Lung Screening Trial (NLST) and the Dutch-Belgian Lung Cancer Screening Trial (NELSON). Results One out of ten smokers (11.6% of men and 9.6% of women) according to NLST criteria and one out of four smokers (24.6% of men and 22.4% of women) according to NELSON criteria are currently at high risk of lung cancer in the EU. According to both criteria, the prevalence of former smokers at high risk of lung cancer is under 10%. Conclusion Around 17 million citizens in the EU according to NLST criteria and 34 million according to NELSON criteria (around 4% and 8% of the adult population, respectively) are at high risk of developing lung cancer. Since the implementation of lung cancer screening programs still remains controversial, primary prevention activities should be encouraged.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1016\/j.canep.2018.10.007<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Del Pozo MDP, Castell\u00f3 A, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Llobet R, Vioque J, P\u00e9rez-G\u00f3mez B, Poll\u00e1n M, Lope V. <\/p>Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study<\/a>. Journal Article<\/span> <\/p>Maturitas. <\/span>2018<\/span>;117<\/span>:57\u201363<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30314562,\r\ntitle = {Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study},\r\nauthor = {Del Pozo MDP and Castell\u00f3 A and Vidal C and Salas-Trejo D and S\u00e1nchez-Contador C and Pedraz-Pingarr\u00f3n C and Moreo P and Santamari\u00f1a C and Ederra M and Llobet R and Vioque J and P\u00e9rez-G\u00f3mez B and Poll\u00e1n M and Lope V},\r\ndoi = {10.1016\/j.maturitas.2018.09.006},\r\nissn = {1873-4111},\r\nyear = {2018},\r\ndate = {2018-11-01},\r\njournal = {Maturitas},\r\nvolume = {117},\r\npages = {57--63},\r\nabstract = {OBJECTIVES: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women.nnSTUDY DESIGN: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey. Predicted calories were calculated using linear regression models, including the basal metabolic rate and physical activity as explanatory variables. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using center-specific mixed ordinal logistic regression models, adjusted for age, menopausal status, body mass index, parity, tobacco use, family history of breast cancer, previous biopsies, age at menarche and adherence to a Western diet.nnMAIN OUTCOME MEASURE: Mammographic density.nnRESULTS: Those women with an excessive caloric intake (>40% above predicted) presented higher MD (OR\u2009=\u20091.41, 95%CI\u2009=\u20090.97-2.03; p\u2009=\u20090.070). For every 20% increase in relative caloric consumption the probability of having higher MD increased by 5% (OR\u2009=\u20091.05, 95%CI\u2009=\u20090.98-1.14; p\u2009=\u20090.178), not observing differences between the categories of explanatory variables. Caloric restriction was not associated with MD in our study.nnCONCLUSIONS: This is the first study exploring the association between MD and the effect of caloric deficit or excessive caloric consumption according to the energy requirements of each woman. Although caloric restriction does not seem to affect breast density, a caloric intake above predicted levels seems to increase this phenotype.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>OBJECTIVES: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women.nnSTUDY DESIGN: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey. Predicted calories were calculated using linear regression models, including the basal metabolic rate and physical activity as explanatory variables. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using center-specific mixed ordinal logistic regression models, adjusted for age, menopausal status, body mass index, parity, tobacco use, family history of breast cancer, previous biopsies, age at menarche and adherence to a Western diet.nnMAIN OUTCOME MEASURE: Mammographic density.nnRESULTS: Those women with an excessive caloric intake (>40% above predicted) presented higher MD (OR\u2009=\u20091.41, 95%CI\u2009=\u20090.97-2.03; p\u2009=\u20090.070). For every 20% increase in relative caloric consumption the probability of having higher MD increased by 5% (OR\u2009=\u20091.05, 95%CI\u2009=\u20090.98-1.14; p\u2009=\u20090.178), not observing differences between the categories of explanatory variables. Caloric restriction was not associated with MD in our study.nnCONCLUSIONS: This is the first study exploring the association between MD and the effect of caloric deficit or excessive caloric consumption according to the energy requirements of each woman. Although caloric restriction does not seem to affect breast density, a caloric intake above predicted levels seems to increase this phenotype.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1016\/j.maturitas.2018.09.006<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Guillam\u00f3 E, Cobo-Calvo \u00c1, Oviedo GR, Travier N, \u00c1lamo J, Ni\u00f1o-Mendez OA, Mart\u00ednez-Yelamos A, Mart\u00ednez-Yelamos S, Javierre C. <\/p>Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study. Journal Article<\/span> <\/p>J Sports Sci Med. <\/span>2018<\/span>;17<\/span>:426\u2013436<\/span>.<\/p>Abstract<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30116116,\r\ntitle = {Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study},\r\nauthor = {Guillam\u00f3 E and Cobo-Calvo \u00c1 and Oviedo GR and Travier N and \u00c1lamo J and Ni\u00f1o-Mendez OA and Mart\u00ednez-Yelamos A and Mart\u00ednez-Yelamos S and Javierre C},\r\nissn = {1303-2968},\r\nyear = {2018},\r\ndate = {2018-09-01},\r\njournal = {J Sports Sci Med},\r\nvolume = {17},\r\nnumber = {3},\r\npages = {426--436},\r\nabstract = {Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.<\/div>Close<\/a><\/p><\/div><\/div><\/div> Travier N, Buckland G, Vendrell JJ, Fernandez-Veledo S, Peir\u00f3 I, Del Barco S, Pernas S, Zamora E, Bellet M, Margeli M, Cirauqui B, Mu\u00f1oz M, Tusquets I, Arcusa A, Javierre C, Moreno F, Rodriguez A, Agudo A. <\/p>Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors<\/a>. Journal Article<\/span> <\/p>Eur J Cancer Care (Engl). <\/span>2018<\/span>;27<\/span>:e12861<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29869823,\r\ntitle = {Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors},\r\nauthor = {Travier N and Buckland G and Vendrell JJ and Fernandez-Veledo S and Peir\u00f3 I and Del Barco S and Pernas S and Zamora E and Bellet M and Margeli M and Cirauqui B and Mu\u00f1oz M and Tusquets I and Arcusa A and Javierre C and Moreno F and Rodriguez A and Agudo A},\r\ndoi = {10.1111\/ecc.12861},\r\nissn = {1365-2354},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Eur J Cancer Care (Engl)},\r\nvolume = {27},\r\nnumber = {4},\r\npages = {e12861},\r\nabstract = {Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/ecc.12861<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Rom\u00e1n M, Caicoya M, Espin\u00e0s J, Sala M, Tor\u00e1-Rocamora I, Quinta MJ, Vernet M, Saladi\u00e9 F, Romero A, S\u00e1nchez M, Bar\u00e9 M, Vidal C, Servitja S, Natal C, Corominas J, Ferrer J, Rodr\u00edguez-Arana A, Castells X, study BELE Project group. <\/p>Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain<\/a>. Journal Article<\/span> <\/p>Breast J. <\/span>2018<\/span>;24<\/span>:509\u2013518<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Cancer Epidemiol. <\/span>2018<\/span>;57<\/span>:140\u2013147<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30497060,\r\ntitle = {Estimation of the adult population at high risk of developing lung cancer in the European Union},\r\nauthor = {Gonz\u00e1lez-Marr\u00f3n A and Mart\u00edn-S\u00e1nchez JC and Matilla-Santander N and Cartany\u00e0-Hueso \u00c0 and Lid\u00f3n-Moyano C and Vidal C and Garc\u00eda M and Mart\u00ednez-S\u00e1nchez JM},\r\ndoi = {10.1016\/j.canep.2018.10.007},\r\nissn = {1877-783X},\r\nyear = {2018},\r\ndate = {2018-12-01},\r\njournal = {Cancer Epidemiol},\r\nvolume = {57},\r\npages = {140--147},\r\nabstract = {Background Lung cancer mortality accounts for over 266,000 deaths in the European Union (EU) every year, most of them attributed to smoking. The aim of this study was to estimate the prevalence of the adult population at high risk of developing lung cancer in the EU in 2014. Methods This is a cross-sectional study. We used data from the Special Eurobarometer 429 (n\u2009=\u200927,801). The fieldwork was conducted between November-December 2014. High risk of lung cancer was defined using the criteria of the National Lung Screening Trial (NLST) and the Dutch-Belgian Lung Cancer Screening Trial (NELSON). Results One out of ten smokers (11.6% of men and 9.6% of women) according to NLST criteria and one out of four smokers (24.6% of men and 22.4% of women) according to NELSON criteria are currently at high risk of lung cancer in the EU. According to both criteria, the prevalence of former smokers at high risk of lung cancer is under 10%. Conclusion Around 17 million citizens in the EU according to NLST criteria and 34 million according to NELSON criteria (around 4% and 8% of the adult population, respectively) are at high risk of developing lung cancer. Since the implementation of lung cancer screening programs still remains controversial, primary prevention activities should be encouraged.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Background Lung cancer mortality accounts for over 266,000 deaths in the European Union (EU) every year, most of them attributed to smoking. The aim of this study was to estimate the prevalence of the adult population at high risk of developing lung cancer in the EU in 2014. Methods This is a cross-sectional study. We used data from the Special Eurobarometer 429 (n\u2009=\u200927,801). The fieldwork was conducted between November-December 2014. High risk of lung cancer was defined using the criteria of the National Lung Screening Trial (NLST) and the Dutch-Belgian Lung Cancer Screening Trial (NELSON). Results One out of ten smokers (11.6% of men and 9.6% of women) according to NLST criteria and one out of four smokers (24.6% of men and 22.4% of women) according to NELSON criteria are currently at high risk of lung cancer in the EU. According to both criteria, the prevalence of former smokers at high risk of lung cancer is under 10%. Conclusion Around 17 million citizens in the EU according to NLST criteria and 34 million according to NELSON criteria (around 4% and 8% of the adult population, respectively) are at high risk of developing lung cancer. Since the implementation of lung cancer screening programs still remains controversial, primary prevention activities should be encouraged.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1016\/j.canep.2018.10.007<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Del Pozo MDP, Castell\u00f3 A, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Llobet R, Vioque J, P\u00e9rez-G\u00f3mez B, Poll\u00e1n M, Lope V. <\/p>Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study<\/a>. Journal Article<\/span> <\/p>Maturitas. <\/span>2018<\/span>;117<\/span>:57\u201363<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30314562,\r\ntitle = {Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study},\r\nauthor = {Del Pozo MDP and Castell\u00f3 A and Vidal C and Salas-Trejo D and S\u00e1nchez-Contador C and Pedraz-Pingarr\u00f3n C and Moreo P and Santamari\u00f1a C and Ederra M and Llobet R and Vioque J and P\u00e9rez-G\u00f3mez B and Poll\u00e1n M and Lope V},\r\ndoi = {10.1016\/j.maturitas.2018.09.006},\r\nissn = {1873-4111},\r\nyear = {2018},\r\ndate = {2018-11-01},\r\njournal = {Maturitas},\r\nvolume = {117},\r\npages = {57--63},\r\nabstract = {OBJECTIVES: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women.nnSTUDY DESIGN: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey. Predicted calories were calculated using linear regression models, including the basal metabolic rate and physical activity as explanatory variables. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using center-specific mixed ordinal logistic regression models, adjusted for age, menopausal status, body mass index, parity, tobacco use, family history of breast cancer, previous biopsies, age at menarche and adherence to a Western diet.nnMAIN OUTCOME MEASURE: Mammographic density.nnRESULTS: Those women with an excessive caloric intake (>40% above predicted) presented higher MD (OR\u2009=\u20091.41, 95%CI\u2009=\u20090.97-2.03; p\u2009=\u20090.070). For every 20% increase in relative caloric consumption the probability of having higher MD increased by 5% (OR\u2009=\u20091.05, 95%CI\u2009=\u20090.98-1.14; p\u2009=\u20090.178), not observing differences between the categories of explanatory variables. Caloric restriction was not associated with MD in our study.nnCONCLUSIONS: This is the first study exploring the association between MD and the effect of caloric deficit or excessive caloric consumption according to the energy requirements of each woman. Although caloric restriction does not seem to affect breast density, a caloric intake above predicted levels seems to increase this phenotype.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>OBJECTIVES: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women.nnSTUDY DESIGN: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey. Predicted calories were calculated using linear regression models, including the basal metabolic rate and physical activity as explanatory variables. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using center-specific mixed ordinal logistic regression models, adjusted for age, menopausal status, body mass index, parity, tobacco use, family history of breast cancer, previous biopsies, age at menarche and adherence to a Western diet.nnMAIN OUTCOME MEASURE: Mammographic density.nnRESULTS: Those women with an excessive caloric intake (>40% above predicted) presented higher MD (OR\u2009=\u20091.41, 95%CI\u2009=\u20090.97-2.03; p\u2009=\u20090.070). For every 20% increase in relative caloric consumption the probability of having higher MD increased by 5% (OR\u2009=\u20091.05, 95%CI\u2009=\u20090.98-1.14; p\u2009=\u20090.178), not observing differences between the categories of explanatory variables. Caloric restriction was not associated with MD in our study.nnCONCLUSIONS: This is the first study exploring the association between MD and the effect of caloric deficit or excessive caloric consumption according to the energy requirements of each woman. Although caloric restriction does not seem to affect breast density, a caloric intake above predicted levels seems to increase this phenotype.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1016\/j.maturitas.2018.09.006<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Guillam\u00f3 E, Cobo-Calvo \u00c1, Oviedo GR, Travier N, \u00c1lamo J, Ni\u00f1o-Mendez OA, Mart\u00ednez-Yelamos A, Mart\u00ednez-Yelamos S, Javierre C. <\/p>Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study. Journal Article<\/span> <\/p>J Sports Sci Med. <\/span>2018<\/span>;17<\/span>:426\u2013436<\/span>.<\/p>Abstract<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30116116,\r\ntitle = {Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study},\r\nauthor = {Guillam\u00f3 E and Cobo-Calvo \u00c1 and Oviedo GR and Travier N and \u00c1lamo J and Ni\u00f1o-Mendez OA and Mart\u00ednez-Yelamos A and Mart\u00ednez-Yelamos S and Javierre C},\r\nissn = {1303-2968},\r\nyear = {2018},\r\ndate = {2018-09-01},\r\njournal = {J Sports Sci Med},\r\nvolume = {17},\r\nnumber = {3},\r\npages = {426--436},\r\nabstract = {Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.<\/div>Close<\/a><\/p><\/div><\/div><\/div> Travier N, Buckland G, Vendrell JJ, Fernandez-Veledo S, Peir\u00f3 I, Del Barco S, Pernas S, Zamora E, Bellet M, Margeli M, Cirauqui B, Mu\u00f1oz M, Tusquets I, Arcusa A, Javierre C, Moreno F, Rodriguez A, Agudo A. <\/p>Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors<\/a>. Journal Article<\/span> <\/p>Eur J Cancer Care (Engl). <\/span>2018<\/span>;27<\/span>:e12861<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29869823,\r\ntitle = {Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors},\r\nauthor = {Travier N and Buckland G and Vendrell JJ and Fernandez-Veledo S and Peir\u00f3 I and Del Barco S and Pernas S and Zamora E and Bellet M and Margeli M and Cirauqui B and Mu\u00f1oz M and Tusquets I and Arcusa A and Javierre C and Moreno F and Rodriguez A and Agudo A},\r\ndoi = {10.1111\/ecc.12861},\r\nissn = {1365-2354},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Eur J Cancer Care (Engl)},\r\nvolume = {27},\r\nnumber = {4},\r\npages = {e12861},\r\nabstract = {Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/ecc.12861<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Rom\u00e1n M, Caicoya M, Espin\u00e0s J, Sala M, Tor\u00e1-Rocamora I, Quinta MJ, Vernet M, Saladi\u00e9 F, Romero A, S\u00e1nchez M, Bar\u00e9 M, Vidal C, Servitja S, Natal C, Corominas J, Ferrer J, Rodr\u00edguez-Arana A, Castells X, study BELE Project group. <\/p>Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain<\/a>. Journal Article<\/span> <\/p>Breast J. <\/span>2018<\/span>;24<\/span>:509\u2013518<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30497060,\r\ntitle = {Estimation of the adult population at high risk of developing lung cancer in the European Union},\r\nauthor = {Gonz\u00e1lez-Marr\u00f3n A and Mart\u00edn-S\u00e1nchez JC and Matilla-Santander N and Cartany\u00e0-Hueso \u00c0 and Lid\u00f3n-Moyano C and Vidal C and Garc\u00eda M and Mart\u00ednez-S\u00e1nchez JM},\r\ndoi = {10.1016\/j.canep.2018.10.007},\r\nissn = {1877-783X},\r\nyear = {2018},\r\ndate = {2018-12-01},\r\njournal = {Cancer Epidemiol},\r\nvolume = {57},\r\npages = {140--147},\r\nabstract = {Background Lung cancer mortality accounts for over 266,000 deaths in the European Union (EU) every year, most of them attributed to smoking. The aim of this study was to estimate the prevalence of the adult population at high risk of developing lung cancer in the EU in 2014. Methods This is a cross-sectional study. We used data from the Special Eurobarometer 429 (n\u2009=\u200927,801). The fieldwork was conducted between November-December 2014. High risk of lung cancer was defined using the criteria of the National Lung Screening Trial (NLST) and the Dutch-Belgian Lung Cancer Screening Trial (NELSON). Results One out of ten smokers (11.6% of men and 9.6% of women) according to NLST criteria and one out of four smokers (24.6% of men and 22.4% of women) according to NELSON criteria are currently at high risk of lung cancer in the EU. According to both criteria, the prevalence of former smokers at high risk of lung cancer is under 10%. Conclusion Around 17 million citizens in the EU according to NLST criteria and 34 million according to NELSON criteria (around 4% and 8% of the adult population, respectively) are at high risk of developing lung cancer. Since the implementation of lung cancer screening programs still remains controversial, primary prevention activities should be encouraged.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Background Lung cancer mortality accounts for over 266,000 deaths in the European Union (EU) every year, most of them attributed to smoking. The aim of this study was to estimate the prevalence of the adult population at high risk of developing lung cancer in the EU in 2014. Methods This is a cross-sectional study. We used data from the Special Eurobarometer 429 (n\u2009=\u200927,801). The fieldwork was conducted between November-December 2014. High risk of lung cancer was defined using the criteria of the National Lung Screening Trial (NLST) and the Dutch-Belgian Lung Cancer Screening Trial (NELSON). Results One out of ten smokers (11.6% of men and 9.6% of women) according to NLST criteria and one out of four smokers (24.6% of men and 22.4% of women) according to NELSON criteria are currently at high risk of lung cancer in the EU. According to both criteria, the prevalence of former smokers at high risk of lung cancer is under 10%. Conclusion Around 17 million citizens in the EU according to NLST criteria and 34 million according to NELSON criteria (around 4% and 8% of the adult population, respectively) are at high risk of developing lung cancer. Since the implementation of lung cancer screening programs still remains controversial, primary prevention activities should be encouraged.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1016\/j.canep.2018.10.007<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Del Pozo MDP, Castell\u00f3 A, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Llobet R, Vioque J, P\u00e9rez-G\u00f3mez B, Poll\u00e1n M, Lope V. <\/p>Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study<\/a>. Journal Article<\/span> <\/p>Maturitas. <\/span>2018<\/span>;117<\/span>:57\u201363<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30314562,\r\ntitle = {Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study},\r\nauthor = {Del Pozo MDP and Castell\u00f3 A and Vidal C and Salas-Trejo D and S\u00e1nchez-Contador C and Pedraz-Pingarr\u00f3n C and Moreo P and Santamari\u00f1a C and Ederra M and Llobet R and Vioque J and P\u00e9rez-G\u00f3mez B and Poll\u00e1n M and Lope V},\r\ndoi = {10.1016\/j.maturitas.2018.09.006},\r\nissn = {1873-4111},\r\nyear = {2018},\r\ndate = {2018-11-01},\r\njournal = {Maturitas},\r\nvolume = {117},\r\npages = {57--63},\r\nabstract = {OBJECTIVES: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women.nnSTUDY DESIGN: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey. Predicted calories were calculated using linear regression models, including the basal metabolic rate and physical activity as explanatory variables. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using center-specific mixed ordinal logistic regression models, adjusted for age, menopausal status, body mass index, parity, tobacco use, family history of breast cancer, previous biopsies, age at menarche and adherence to a Western diet.nnMAIN OUTCOME MEASURE: Mammographic density.nnRESULTS: Those women with an excessive caloric intake (>40% above predicted) presented higher MD (OR\u2009=\u20091.41, 95%CI\u2009=\u20090.97-2.03; p\u2009=\u20090.070). For every 20% increase in relative caloric consumption the probability of having higher MD increased by 5% (OR\u2009=\u20091.05, 95%CI\u2009=\u20090.98-1.14; p\u2009=\u20090.178), not observing differences between the categories of explanatory variables. Caloric restriction was not associated with MD in our study.nnCONCLUSIONS: This is the first study exploring the association between MD and the effect of caloric deficit or excessive caloric consumption according to the energy requirements of each woman. Although caloric restriction does not seem to affect breast density, a caloric intake above predicted levels seems to increase this phenotype.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>OBJECTIVES: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women.nnSTUDY DESIGN: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey. Predicted calories were calculated using linear regression models, including the basal metabolic rate and physical activity as explanatory variables. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using center-specific mixed ordinal logistic regression models, adjusted for age, menopausal status, body mass index, parity, tobacco use, family history of breast cancer, previous biopsies, age at menarche and adherence to a Western diet.nnMAIN OUTCOME MEASURE: Mammographic density.nnRESULTS: Those women with an excessive caloric intake (>40% above predicted) presented higher MD (OR\u2009=\u20091.41, 95%CI\u2009=\u20090.97-2.03; p\u2009=\u20090.070). For every 20% increase in relative caloric consumption the probability of having higher MD increased by 5% (OR\u2009=\u20091.05, 95%CI\u2009=\u20090.98-1.14; p\u2009=\u20090.178), not observing differences between the categories of explanatory variables. Caloric restriction was not associated with MD in our study.nnCONCLUSIONS: This is the first study exploring the association between MD and the effect of caloric deficit or excessive caloric consumption according to the energy requirements of each woman. Although caloric restriction does not seem to affect breast density, a caloric intake above predicted levels seems to increase this phenotype.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1016\/j.maturitas.2018.09.006<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Guillam\u00f3 E, Cobo-Calvo \u00c1, Oviedo GR, Travier N, \u00c1lamo J, Ni\u00f1o-Mendez OA, Mart\u00ednez-Yelamos A, Mart\u00ednez-Yelamos S, Javierre C. <\/p>Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study. Journal Article<\/span> <\/p>J Sports Sci Med. <\/span>2018<\/span>;17<\/span>:426\u2013436<\/span>.<\/p>Abstract<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30116116,\r\ntitle = {Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study},\r\nauthor = {Guillam\u00f3 E and Cobo-Calvo \u00c1 and Oviedo GR and Travier N and \u00c1lamo J and Ni\u00f1o-Mendez OA and Mart\u00ednez-Yelamos A and Mart\u00ednez-Yelamos S and Javierre C},\r\nissn = {1303-2968},\r\nyear = {2018},\r\ndate = {2018-09-01},\r\njournal = {J Sports Sci Med},\r\nvolume = {17},\r\nnumber = {3},\r\npages = {426--436},\r\nabstract = {Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.<\/div>Close<\/a><\/p><\/div><\/div><\/div> Travier N, Buckland G, Vendrell JJ, Fernandez-Veledo S, Peir\u00f3 I, Del Barco S, Pernas S, Zamora E, Bellet M, Margeli M, Cirauqui B, Mu\u00f1oz M, Tusquets I, Arcusa A, Javierre C, Moreno F, Rodriguez A, Agudo A. <\/p>Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors<\/a>. Journal Article<\/span> <\/p>Eur J Cancer Care (Engl). <\/span>2018<\/span>;27<\/span>:e12861<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29869823,\r\ntitle = {Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors},\r\nauthor = {Travier N and Buckland G and Vendrell JJ and Fernandez-Veledo S and Peir\u00f3 I and Del Barco S and Pernas S and Zamora E and Bellet M and Margeli M and Cirauqui B and Mu\u00f1oz M and Tusquets I and Arcusa A and Javierre C and Moreno F and Rodriguez A and Agudo A},\r\ndoi = {10.1111\/ecc.12861},\r\nissn = {1365-2354},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Eur J Cancer Care (Engl)},\r\nvolume = {27},\r\nnumber = {4},\r\npages = {e12861},\r\nabstract = {Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/ecc.12861<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Rom\u00e1n M, Caicoya M, Espin\u00e0s J, Sala M, Tor\u00e1-Rocamora I, Quinta MJ, Vernet M, Saladi\u00e9 F, Romero A, S\u00e1nchez M, Bar\u00e9 M, Vidal C, Servitja S, Natal C, Corominas J, Ferrer J, Rodr\u00edguez-Arana A, Castells X, study BELE Project group. <\/p>Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain<\/a>. Journal Article<\/span> <\/p>Breast J. <\/span>2018<\/span>;24<\/span>:509\u2013518<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
@article{pmid30497060,\r\ntitle = {Estimation of the adult population at high risk of developing lung cancer in the European Union},\r\nauthor = {Gonz\u00e1lez-Marr\u00f3n A and Mart\u00edn-S\u00e1nchez JC and Matilla-Santander N and Cartany\u00e0-Hueso \u00c0 and Lid\u00f3n-Moyano C and Vidal C and Garc\u00eda M and Mart\u00ednez-S\u00e1nchez JM},\r\ndoi = {10.1016\/j.canep.2018.10.007},\r\nissn = {1877-783X},\r\nyear = {2018},\r\ndate = {2018-12-01},\r\njournal = {Cancer Epidemiol},\r\nvolume = {57},\r\npages = {140--147},\r\nabstract = {Background Lung cancer mortality accounts for over 266,000 deaths in the European Union (EU) every year, most of them attributed to smoking. The aim of this study was to estimate the prevalence of the adult population at high risk of developing lung cancer in the EU in 2014. Methods This is a cross-sectional study. We used data from the Special Eurobarometer 429 (n\u2009=\u200927,801). The fieldwork was conducted between November-December 2014. High risk of lung cancer was defined using the criteria of the National Lung Screening Trial (NLST) and the Dutch-Belgian Lung Cancer Screening Trial (NELSON). Results One out of ten smokers (11.6% of men and 9.6% of women) according to NLST criteria and one out of four smokers (24.6% of men and 22.4% of women) according to NELSON criteria are currently at high risk of lung cancer in the EU. According to both criteria, the prevalence of former smokers at high risk of lung cancer is under 10%. Conclusion Around 17 million citizens in the EU according to NLST criteria and 34 million according to NELSON criteria (around 4% and 8% of the adult population, respectively) are at high risk of developing lung cancer. Since the implementation of lung cancer screening programs still remains controversial, primary prevention activities should be encouraged.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Background Lung cancer mortality accounts for over 266,000 deaths in the European Union (EU) every year, most of them attributed to smoking. The aim of this study was to estimate the prevalence of the adult population at high risk of developing lung cancer in the EU in 2014. Methods This is a cross-sectional study. We used data from the Special Eurobarometer 429 (n\u2009=\u200927,801). The fieldwork was conducted between November-December 2014. High risk of lung cancer was defined using the criteria of the National Lung Screening Trial (NLST) and the Dutch-Belgian Lung Cancer Screening Trial (NELSON). Results One out of ten smokers (11.6% of men and 9.6% of women) according to NLST criteria and one out of four smokers (24.6% of men and 22.4% of women) according to NELSON criteria are currently at high risk of lung cancer in the EU. According to both criteria, the prevalence of former smokers at high risk of lung cancer is under 10%. Conclusion Around 17 million citizens in the EU according to NLST criteria and 34 million according to NELSON criteria (around 4% and 8% of the adult population, respectively) are at high risk of developing lung cancer. Since the implementation of lung cancer screening programs still remains controversial, primary prevention activities should be encouraged.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1016\/j.canep.2018.10.007<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Del Pozo MDP, Castell\u00f3 A, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Llobet R, Vioque J, P\u00e9rez-G\u00f3mez B, Poll\u00e1n M, Lope V. <\/p>Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study<\/a>. Journal Article<\/span> <\/p>Maturitas. <\/span>2018<\/span>;117<\/span>:57\u201363<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30314562,\r\ntitle = {Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study},\r\nauthor = {Del Pozo MDP and Castell\u00f3 A and Vidal C and Salas-Trejo D and S\u00e1nchez-Contador C and Pedraz-Pingarr\u00f3n C and Moreo P and Santamari\u00f1a C and Ederra M and Llobet R and Vioque J and P\u00e9rez-G\u00f3mez B and Poll\u00e1n M and Lope V},\r\ndoi = {10.1016\/j.maturitas.2018.09.006},\r\nissn = {1873-4111},\r\nyear = {2018},\r\ndate = {2018-11-01},\r\njournal = {Maturitas},\r\nvolume = {117},\r\npages = {57--63},\r\nabstract = {OBJECTIVES: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women.nnSTUDY DESIGN: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey. Predicted calories were calculated using linear regression models, including the basal metabolic rate and physical activity as explanatory variables. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using center-specific mixed ordinal logistic regression models, adjusted for age, menopausal status, body mass index, parity, tobacco use, family history of breast cancer, previous biopsies, age at menarche and adherence to a Western diet.nnMAIN OUTCOME MEASURE: Mammographic density.nnRESULTS: Those women with an excessive caloric intake (>40% above predicted) presented higher MD (OR\u2009=\u20091.41, 95%CI\u2009=\u20090.97-2.03; p\u2009=\u20090.070). For every 20% increase in relative caloric consumption the probability of having higher MD increased by 5% (OR\u2009=\u20091.05, 95%CI\u2009=\u20090.98-1.14; p\u2009=\u20090.178), not observing differences between the categories of explanatory variables. Caloric restriction was not associated with MD in our study.nnCONCLUSIONS: This is the first study exploring the association between MD and the effect of caloric deficit or excessive caloric consumption according to the energy requirements of each woman. Although caloric restriction does not seem to affect breast density, a caloric intake above predicted levels seems to increase this phenotype.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>OBJECTIVES: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women.nnSTUDY DESIGN: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey. Predicted calories were calculated using linear regression models, including the basal metabolic rate and physical activity as explanatory variables. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using center-specific mixed ordinal logistic regression models, adjusted for age, menopausal status, body mass index, parity, tobacco use, family history of breast cancer, previous biopsies, age at menarche and adherence to a Western diet.nnMAIN OUTCOME MEASURE: Mammographic density.nnRESULTS: Those women with an excessive caloric intake (>40% above predicted) presented higher MD (OR\u2009=\u20091.41, 95%CI\u2009=\u20090.97-2.03; p\u2009=\u20090.070). For every 20% increase in relative caloric consumption the probability of having higher MD increased by 5% (OR\u2009=\u20091.05, 95%CI\u2009=\u20090.98-1.14; p\u2009=\u20090.178), not observing differences between the categories of explanatory variables. Caloric restriction was not associated with MD in our study.nnCONCLUSIONS: This is the first study exploring the association between MD and the effect of caloric deficit or excessive caloric consumption according to the energy requirements of each woman. Although caloric restriction does not seem to affect breast density, a caloric intake above predicted levels seems to increase this phenotype.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1016\/j.maturitas.2018.09.006<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Guillam\u00f3 E, Cobo-Calvo \u00c1, Oviedo GR, Travier N, \u00c1lamo J, Ni\u00f1o-Mendez OA, Mart\u00ednez-Yelamos A, Mart\u00ednez-Yelamos S, Javierre C. <\/p>Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study. Journal Article<\/span> <\/p>J Sports Sci Med. <\/span>2018<\/span>;17<\/span>:426\u2013436<\/span>.<\/p>Abstract<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30116116,\r\ntitle = {Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study},\r\nauthor = {Guillam\u00f3 E and Cobo-Calvo \u00c1 and Oviedo GR and Travier N and \u00c1lamo J and Ni\u00f1o-Mendez OA and Mart\u00ednez-Yelamos A and Mart\u00ednez-Yelamos S and Javierre C},\r\nissn = {1303-2968},\r\nyear = {2018},\r\ndate = {2018-09-01},\r\njournal = {J Sports Sci Med},\r\nvolume = {17},\r\nnumber = {3},\r\npages = {426--436},\r\nabstract = {Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.<\/div>Close<\/a><\/p><\/div><\/div><\/div> Travier N, Buckland G, Vendrell JJ, Fernandez-Veledo S, Peir\u00f3 I, Del Barco S, Pernas S, Zamora E, Bellet M, Margeli M, Cirauqui B, Mu\u00f1oz M, Tusquets I, Arcusa A, Javierre C, Moreno F, Rodriguez A, Agudo A. <\/p>Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors<\/a>. Journal Article<\/span> <\/p>Eur J Cancer Care (Engl). <\/span>2018<\/span>;27<\/span>:e12861<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29869823,\r\ntitle = {Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors},\r\nauthor = {Travier N and Buckland G and Vendrell JJ and Fernandez-Veledo S and Peir\u00f3 I and Del Barco S and Pernas S and Zamora E and Bellet M and Margeli M and Cirauqui B and Mu\u00f1oz M and Tusquets I and Arcusa A and Javierre C and Moreno F and Rodriguez A and Agudo A},\r\ndoi = {10.1111\/ecc.12861},\r\nissn = {1365-2354},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Eur J Cancer Care (Engl)},\r\nvolume = {27},\r\nnumber = {4},\r\npages = {e12861},\r\nabstract = {Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/ecc.12861<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Rom\u00e1n M, Caicoya M, Espin\u00e0s J, Sala M, Tor\u00e1-Rocamora I, Quinta MJ, Vernet M, Saladi\u00e9 F, Romero A, S\u00e1nchez M, Bar\u00e9 M, Vidal C, Servitja S, Natal C, Corominas J, Ferrer J, Rodr\u00edguez-Arana A, Castells X, study BELE Project group. <\/p>Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain<\/a>. Journal Article<\/span> <\/p>Breast J. <\/span>2018<\/span>;24<\/span>:509\u2013518<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Close<\/a><\/p><\/div>Background Lung cancer mortality accounts for over 266,000 deaths in the European Union (EU) every year, most of them attributed to smoking. The aim of this study was to estimate the prevalence of the adult population at high risk of developing lung cancer in the EU in 2014. Methods This is a cross-sectional study. We used data from the Special Eurobarometer 429 (n\u2009=\u200927,801). The fieldwork was conducted between November-December 2014. High risk of lung cancer was defined using the criteria of the National Lung Screening Trial (NLST) and the Dutch-Belgian Lung Cancer Screening Trial (NELSON). Results One out of ten smokers (11.6% of men and 9.6% of women) according to NLST criteria and one out of four smokers (24.6% of men and 22.4% of women) according to NELSON criteria are currently at high risk of lung cancer in the EU. According to both criteria, the prevalence of former smokers at high risk of lung cancer is under 10%. Conclusion Around 17 million citizens in the EU according to NLST criteria and 34 million according to NELSON criteria (around 4% and 8% of the adult population, respectively) are at high risk of developing lung cancer. Since the implementation of lung cancer screening programs still remains controversial, primary prevention activities should be encouraged.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1016\/j.canep.2018.10.007<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Del Pozo MDP, Castell\u00f3 A, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Llobet R, Vioque J, P\u00e9rez-G\u00f3mez B, Poll\u00e1n M, Lope V. <\/p>Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study<\/a>. Journal Article<\/span> <\/p>Maturitas. <\/span>2018<\/span>;117<\/span>:57\u201363<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30314562,\r\ntitle = {Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study},\r\nauthor = {Del Pozo MDP and Castell\u00f3 A and Vidal C and Salas-Trejo D and S\u00e1nchez-Contador C and Pedraz-Pingarr\u00f3n C and Moreo P and Santamari\u00f1a C and Ederra M and Llobet R and Vioque J and P\u00e9rez-G\u00f3mez B and Poll\u00e1n M and Lope V},\r\ndoi = {10.1016\/j.maturitas.2018.09.006},\r\nissn = {1873-4111},\r\nyear = {2018},\r\ndate = {2018-11-01},\r\njournal = {Maturitas},\r\nvolume = {117},\r\npages = {57--63},\r\nabstract = {OBJECTIVES: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women.nnSTUDY DESIGN: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey. Predicted calories were calculated using linear regression models, including the basal metabolic rate and physical activity as explanatory variables. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using center-specific mixed ordinal logistic regression models, adjusted for age, menopausal status, body mass index, parity, tobacco use, family history of breast cancer, previous biopsies, age at menarche and adherence to a Western diet.nnMAIN OUTCOME MEASURE: Mammographic density.nnRESULTS: Those women with an excessive caloric intake (>40% above predicted) presented higher MD (OR\u2009=\u20091.41, 95%CI\u2009=\u20090.97-2.03; p\u2009=\u20090.070). For every 20% increase in relative caloric consumption the probability of having higher MD increased by 5% (OR\u2009=\u20091.05, 95%CI\u2009=\u20090.98-1.14; p\u2009=\u20090.178), not observing differences between the categories of explanatory variables. Caloric restriction was not associated with MD in our study.nnCONCLUSIONS: This is the first study exploring the association between MD and the effect of caloric deficit or excessive caloric consumption according to the energy requirements of each woman. Although caloric restriction does not seem to affect breast density, a caloric intake above predicted levels seems to increase this phenotype.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>OBJECTIVES: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women.nnSTUDY DESIGN: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey. Predicted calories were calculated using linear regression models, including the basal metabolic rate and physical activity as explanatory variables. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using center-specific mixed ordinal logistic regression models, adjusted for age, menopausal status, body mass index, parity, tobacco use, family history of breast cancer, previous biopsies, age at menarche and adherence to a Western diet.nnMAIN OUTCOME MEASURE: Mammographic density.nnRESULTS: Those women with an excessive caloric intake (>40% above predicted) presented higher MD (OR\u2009=\u20091.41, 95%CI\u2009=\u20090.97-2.03; p\u2009=\u20090.070). For every 20% increase in relative caloric consumption the probability of having higher MD increased by 5% (OR\u2009=\u20091.05, 95%CI\u2009=\u20090.98-1.14; p\u2009=\u20090.178), not observing differences between the categories of explanatory variables. Caloric restriction was not associated with MD in our study.nnCONCLUSIONS: This is the first study exploring the association between MD and the effect of caloric deficit or excessive caloric consumption according to the energy requirements of each woman. Although caloric restriction does not seem to affect breast density, a caloric intake above predicted levels seems to increase this phenotype.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1016\/j.maturitas.2018.09.006<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Guillam\u00f3 E, Cobo-Calvo \u00c1, Oviedo GR, Travier N, \u00c1lamo J, Ni\u00f1o-Mendez OA, Mart\u00ednez-Yelamos A, Mart\u00ednez-Yelamos S, Javierre C. <\/p>Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study. Journal Article<\/span> <\/p>J Sports Sci Med. <\/span>2018<\/span>;17<\/span>:426\u2013436<\/span>.<\/p>Abstract<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30116116,\r\ntitle = {Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study},\r\nauthor = {Guillam\u00f3 E and Cobo-Calvo \u00c1 and Oviedo GR and Travier N and \u00c1lamo J and Ni\u00f1o-Mendez OA and Mart\u00ednez-Yelamos A and Mart\u00ednez-Yelamos S and Javierre C},\r\nissn = {1303-2968},\r\nyear = {2018},\r\ndate = {2018-09-01},\r\njournal = {J Sports Sci Med},\r\nvolume = {17},\r\nnumber = {3},\r\npages = {426--436},\r\nabstract = {Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.<\/div>Close<\/a><\/p><\/div><\/div><\/div> Travier N, Buckland G, Vendrell JJ, Fernandez-Veledo S, Peir\u00f3 I, Del Barco S, Pernas S, Zamora E, Bellet M, Margeli M, Cirauqui B, Mu\u00f1oz M, Tusquets I, Arcusa A, Javierre C, Moreno F, Rodriguez A, Agudo A. <\/p>Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors<\/a>. Journal Article<\/span> <\/p>Eur J Cancer Care (Engl). <\/span>2018<\/span>;27<\/span>:e12861<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29869823,\r\ntitle = {Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors},\r\nauthor = {Travier N and Buckland G and Vendrell JJ and Fernandez-Veledo S and Peir\u00f3 I and Del Barco S and Pernas S and Zamora E and Bellet M and Margeli M and Cirauqui B and Mu\u00f1oz M and Tusquets I and Arcusa A and Javierre C and Moreno F and Rodriguez A and Agudo A},\r\ndoi = {10.1111\/ecc.12861},\r\nissn = {1365-2354},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Eur J Cancer Care (Engl)},\r\nvolume = {27},\r\nnumber = {4},\r\npages = {e12861},\r\nabstract = {Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/ecc.12861<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Rom\u00e1n M, Caicoya M, Espin\u00e0s J, Sala M, Tor\u00e1-Rocamora I, Quinta MJ, Vernet M, Saladi\u00e9 F, Romero A, S\u00e1nchez M, Bar\u00e9 M, Vidal C, Servitja S, Natal C, Corominas J, Ferrer J, Rodr\u00edguez-Arana A, Castells X, study BELE Project group. <\/p>Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain<\/a>. Journal Article<\/span> <\/p>Breast J. <\/span>2018<\/span>;24<\/span>:509\u2013518<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Close<\/a><\/p><\/div><\/i>doi:10.1016\/j.canep.2018.10.007<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Del Pozo MDP, Castell\u00f3 A, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Llobet R, Vioque J, P\u00e9rez-G\u00f3mez B, Poll\u00e1n M, Lope V. <\/p>Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study<\/a>. Journal Article<\/span> <\/p>Maturitas. <\/span>2018<\/span>;117<\/span>:57\u201363<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30314562,\r\ntitle = {Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study},\r\nauthor = {Del Pozo MDP and Castell\u00f3 A and Vidal C and Salas-Trejo D and S\u00e1nchez-Contador C and Pedraz-Pingarr\u00f3n C and Moreo P and Santamari\u00f1a C and Ederra M and Llobet R and Vioque J and P\u00e9rez-G\u00f3mez B and Poll\u00e1n M and Lope V},\r\ndoi = {10.1016\/j.maturitas.2018.09.006},\r\nissn = {1873-4111},\r\nyear = {2018},\r\ndate = {2018-11-01},\r\njournal = {Maturitas},\r\nvolume = {117},\r\npages = {57--63},\r\nabstract = {OBJECTIVES: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women.nnSTUDY DESIGN: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey. Predicted calories were calculated using linear regression models, including the basal metabolic rate and physical activity as explanatory variables. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using center-specific mixed ordinal logistic regression models, adjusted for age, menopausal status, body mass index, parity, tobacco use, family history of breast cancer, previous biopsies, age at menarche and adherence to a Western diet.nnMAIN OUTCOME MEASURE: Mammographic density.nnRESULTS: Those women with an excessive caloric intake (>40% above predicted) presented higher MD (OR\u2009=\u20091.41, 95%CI\u2009=\u20090.97-2.03; p\u2009=\u20090.070). For every 20% increase in relative caloric consumption the probability of having higher MD increased by 5% (OR\u2009=\u20091.05, 95%CI\u2009=\u20090.98-1.14; p\u2009=\u20090.178), not observing differences between the categories of explanatory variables. Caloric restriction was not associated with MD in our study.nnCONCLUSIONS: This is the first study exploring the association between MD and the effect of caloric deficit or excessive caloric consumption according to the energy requirements of each woman. Although caloric restriction does not seem to affect breast density, a caloric intake above predicted levels seems to increase this phenotype.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>OBJECTIVES: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women.nnSTUDY DESIGN: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey. Predicted calories were calculated using linear regression models, including the basal metabolic rate and physical activity as explanatory variables. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using center-specific mixed ordinal logistic regression models, adjusted for age, menopausal status, body mass index, parity, tobacco use, family history of breast cancer, previous biopsies, age at menarche and adherence to a Western diet.nnMAIN OUTCOME MEASURE: Mammographic density.nnRESULTS: Those women with an excessive caloric intake (>40% above predicted) presented higher MD (OR\u2009=\u20091.41, 95%CI\u2009=\u20090.97-2.03; p\u2009=\u20090.070). For every 20% increase in relative caloric consumption the probability of having higher MD increased by 5% (OR\u2009=\u20091.05, 95%CI\u2009=\u20090.98-1.14; p\u2009=\u20090.178), not observing differences between the categories of explanatory variables. Caloric restriction was not associated with MD in our study.nnCONCLUSIONS: This is the first study exploring the association between MD and the effect of caloric deficit or excessive caloric consumption according to the energy requirements of each woman. Although caloric restriction does not seem to affect breast density, a caloric intake above predicted levels seems to increase this phenotype.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1016\/j.maturitas.2018.09.006<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Guillam\u00f3 E, Cobo-Calvo \u00c1, Oviedo GR, Travier N, \u00c1lamo J, Ni\u00f1o-Mendez OA, Mart\u00ednez-Yelamos A, Mart\u00ednez-Yelamos S, Javierre C. <\/p>Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study. Journal Article<\/span> <\/p>J Sports Sci Med. <\/span>2018<\/span>;17<\/span>:426\u2013436<\/span>.<\/p>Abstract<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30116116,\r\ntitle = {Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study},\r\nauthor = {Guillam\u00f3 E and Cobo-Calvo \u00c1 and Oviedo GR and Travier N and \u00c1lamo J and Ni\u00f1o-Mendez OA and Mart\u00ednez-Yelamos A and Mart\u00ednez-Yelamos S and Javierre C},\r\nissn = {1303-2968},\r\nyear = {2018},\r\ndate = {2018-09-01},\r\njournal = {J Sports Sci Med},\r\nvolume = {17},\r\nnumber = {3},\r\npages = {426--436},\r\nabstract = {Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.<\/div>Close<\/a><\/p><\/div><\/div><\/div> Travier N, Buckland G, Vendrell JJ, Fernandez-Veledo S, Peir\u00f3 I, Del Barco S, Pernas S, Zamora E, Bellet M, Margeli M, Cirauqui B, Mu\u00f1oz M, Tusquets I, Arcusa A, Javierre C, Moreno F, Rodriguez A, Agudo A. <\/p>Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors<\/a>. Journal Article<\/span> <\/p>Eur J Cancer Care (Engl). <\/span>2018<\/span>;27<\/span>:e12861<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29869823,\r\ntitle = {Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors},\r\nauthor = {Travier N and Buckland G and Vendrell JJ and Fernandez-Veledo S and Peir\u00f3 I and Del Barco S and Pernas S and Zamora E and Bellet M and Margeli M and Cirauqui B and Mu\u00f1oz M and Tusquets I and Arcusa A and Javierre C and Moreno F and Rodriguez A and Agudo A},\r\ndoi = {10.1111\/ecc.12861},\r\nissn = {1365-2354},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Eur J Cancer Care (Engl)},\r\nvolume = {27},\r\nnumber = {4},\r\npages = {e12861},\r\nabstract = {Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/ecc.12861<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Rom\u00e1n M, Caicoya M, Espin\u00e0s J, Sala M, Tor\u00e1-Rocamora I, Quinta MJ, Vernet M, Saladi\u00e9 F, Romero A, S\u00e1nchez M, Bar\u00e9 M, Vidal C, Servitja S, Natal C, Corominas J, Ferrer J, Rodr\u00edguez-Arana A, Castells X, study BELE Project group. <\/p>Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain<\/a>. Journal Article<\/span> <\/p>Breast J. <\/span>2018<\/span>;24<\/span>:509\u2013518<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Close<\/a><\/p><\/div><\/div><\/div> Del Pozo MDP, Castell\u00f3 A, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Llobet R, Vioque J, P\u00e9rez-G\u00f3mez B, Poll\u00e1n M, Lope V. <\/p>Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study<\/a>. Journal Article<\/span> <\/p>Maturitas. <\/span>2018<\/span>;117<\/span>:57\u201363<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30314562,\r\ntitle = {Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study},\r\nauthor = {Del Pozo MDP and Castell\u00f3 A and Vidal C and Salas-Trejo D and S\u00e1nchez-Contador C and Pedraz-Pingarr\u00f3n C and Moreo P and Santamari\u00f1a C and Ederra M and Llobet R and Vioque J and P\u00e9rez-G\u00f3mez B and Poll\u00e1n M and Lope V},\r\ndoi = {10.1016\/j.maturitas.2018.09.006},\r\nissn = {1873-4111},\r\nyear = {2018},\r\ndate = {2018-11-01},\r\njournal = {Maturitas},\r\nvolume = {117},\r\npages = {57--63},\r\nabstract = {OBJECTIVES: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women.nnSTUDY DESIGN: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey. Predicted calories were calculated using linear regression models, including the basal metabolic rate and physical activity as explanatory variables. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using center-specific mixed ordinal logistic regression models, adjusted for age, menopausal status, body mass index, parity, tobacco use, family history of breast cancer, previous biopsies, age at menarche and adherence to a Western diet.nnMAIN OUTCOME MEASURE: Mammographic density.nnRESULTS: Those women with an excessive caloric intake (>40% above predicted) presented higher MD (OR\u2009=\u20091.41, 95%CI\u2009=\u20090.97-2.03; p\u2009=\u20090.070). For every 20% increase in relative caloric consumption the probability of having higher MD increased by 5% (OR\u2009=\u20091.05, 95%CI\u2009=\u20090.98-1.14; p\u2009=\u20090.178), not observing differences between the categories of explanatory variables. Caloric restriction was not associated with MD in our study.nnCONCLUSIONS: This is the first study exploring the association between MD and the effect of caloric deficit or excessive caloric consumption according to the energy requirements of each woman. Although caloric restriction does not seem to affect breast density, a caloric intake above predicted levels seems to increase this phenotype.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>OBJECTIVES: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women.nnSTUDY DESIGN: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey. Predicted calories were calculated using linear regression models, including the basal metabolic rate and physical activity as explanatory variables. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using center-specific mixed ordinal logistic regression models, adjusted for age, menopausal status, body mass index, parity, tobacco use, family history of breast cancer, previous biopsies, age at menarche and adherence to a Western diet.nnMAIN OUTCOME MEASURE: Mammographic density.nnRESULTS: Those women with an excessive caloric intake (>40% above predicted) presented higher MD (OR\u2009=\u20091.41, 95%CI\u2009=\u20090.97-2.03; p\u2009=\u20090.070). For every 20% increase in relative caloric consumption the probability of having higher MD increased by 5% (OR\u2009=\u20091.05, 95%CI\u2009=\u20090.98-1.14; p\u2009=\u20090.178), not observing differences between the categories of explanatory variables. Caloric restriction was not associated with MD in our study.nnCONCLUSIONS: This is the first study exploring the association between MD and the effect of caloric deficit or excessive caloric consumption according to the energy requirements of each woman. Although caloric restriction does not seem to affect breast density, a caloric intake above predicted levels seems to increase this phenotype.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1016\/j.maturitas.2018.09.006<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Guillam\u00f3 E, Cobo-Calvo \u00c1, Oviedo GR, Travier N, \u00c1lamo J, Ni\u00f1o-Mendez OA, Mart\u00ednez-Yelamos A, Mart\u00ednez-Yelamos S, Javierre C. <\/p>Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study. Journal Article<\/span> <\/p>J Sports Sci Med. <\/span>2018<\/span>;17<\/span>:426\u2013436<\/span>.<\/p>Abstract<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30116116,\r\ntitle = {Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study},\r\nauthor = {Guillam\u00f3 E and Cobo-Calvo \u00c1 and Oviedo GR and Travier N and \u00c1lamo J and Ni\u00f1o-Mendez OA and Mart\u00ednez-Yelamos A and Mart\u00ednez-Yelamos S and Javierre C},\r\nissn = {1303-2968},\r\nyear = {2018},\r\ndate = {2018-09-01},\r\njournal = {J Sports Sci Med},\r\nvolume = {17},\r\nnumber = {3},\r\npages = {426--436},\r\nabstract = {Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.<\/div>Close<\/a><\/p><\/div><\/div><\/div> Travier N, Buckland G, Vendrell JJ, Fernandez-Veledo S, Peir\u00f3 I, Del Barco S, Pernas S, Zamora E, Bellet M, Margeli M, Cirauqui B, Mu\u00f1oz M, Tusquets I, Arcusa A, Javierre C, Moreno F, Rodriguez A, Agudo A. <\/p>Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors<\/a>. Journal Article<\/span> <\/p>Eur J Cancer Care (Engl). <\/span>2018<\/span>;27<\/span>:e12861<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29869823,\r\ntitle = {Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors},\r\nauthor = {Travier N and Buckland G and Vendrell JJ and Fernandez-Veledo S and Peir\u00f3 I and Del Barco S and Pernas S and Zamora E and Bellet M and Margeli M and Cirauqui B and Mu\u00f1oz M and Tusquets I and Arcusa A and Javierre C and Moreno F and Rodriguez A and Agudo A},\r\ndoi = {10.1111\/ecc.12861},\r\nissn = {1365-2354},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Eur J Cancer Care (Engl)},\r\nvolume = {27},\r\nnumber = {4},\r\npages = {e12861},\r\nabstract = {Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/ecc.12861<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Rom\u00e1n M, Caicoya M, Espin\u00e0s J, Sala M, Tor\u00e1-Rocamora I, Quinta MJ, Vernet M, Saladi\u00e9 F, Romero A, S\u00e1nchez M, Bar\u00e9 M, Vidal C, Servitja S, Natal C, Corominas J, Ferrer J, Rodr\u00edguez-Arana A, Castells X, study BELE Project group. <\/p>Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain<\/a>. Journal Article<\/span> <\/p>Breast J. <\/span>2018<\/span>;24<\/span>:509\u2013518<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Del Pozo MDP, Castell\u00f3 A, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Llobet R, Vioque J, P\u00e9rez-G\u00f3mez B, Poll\u00e1n M, Lope V. <\/p>
Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study<\/a>. Journal Article<\/span> <\/p>Maturitas. <\/span>2018<\/span>;117<\/span>:57\u201363<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30314562,\r\ntitle = {Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study},\r\nauthor = {Del Pozo MDP and Castell\u00f3 A and Vidal C and Salas-Trejo D and S\u00e1nchez-Contador C and Pedraz-Pingarr\u00f3n C and Moreo P and Santamari\u00f1a C and Ederra M and Llobet R and Vioque J and P\u00e9rez-G\u00f3mez B and Poll\u00e1n M and Lope V},\r\ndoi = {10.1016\/j.maturitas.2018.09.006},\r\nissn = {1873-4111},\r\nyear = {2018},\r\ndate = {2018-11-01},\r\njournal = {Maturitas},\r\nvolume = {117},\r\npages = {57--63},\r\nabstract = {OBJECTIVES: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women.nnSTUDY DESIGN: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey. Predicted calories were calculated using linear regression models, including the basal metabolic rate and physical activity as explanatory variables. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using center-specific mixed ordinal logistic regression models, adjusted for age, menopausal status, body mass index, parity, tobacco use, family history of breast cancer, previous biopsies, age at menarche and adherence to a Western diet.nnMAIN OUTCOME MEASURE: Mammographic density.nnRESULTS: Those women with an excessive caloric intake (>40% above predicted) presented higher MD (OR\u2009=\u20091.41, 95%CI\u2009=\u20090.97-2.03; p\u2009=\u20090.070). For every 20% increase in relative caloric consumption the probability of having higher MD increased by 5% (OR\u2009=\u20091.05, 95%CI\u2009=\u20090.98-1.14; p\u2009=\u20090.178), not observing differences between the categories of explanatory variables. Caloric restriction was not associated with MD in our study.nnCONCLUSIONS: This is the first study exploring the association between MD and the effect of caloric deficit or excessive caloric consumption according to the energy requirements of each woman. Although caloric restriction does not seem to affect breast density, a caloric intake above predicted levels seems to increase this phenotype.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>OBJECTIVES: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women.nnSTUDY DESIGN: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey. Predicted calories were calculated using linear regression models, including the basal metabolic rate and physical activity as explanatory variables. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using center-specific mixed ordinal logistic regression models, adjusted for age, menopausal status, body mass index, parity, tobacco use, family history of breast cancer, previous biopsies, age at menarche and adherence to a Western diet.nnMAIN OUTCOME MEASURE: Mammographic density.nnRESULTS: Those women with an excessive caloric intake (>40% above predicted) presented higher MD (OR\u2009=\u20091.41, 95%CI\u2009=\u20090.97-2.03; p\u2009=\u20090.070). For every 20% increase in relative caloric consumption the probability of having higher MD increased by 5% (OR\u2009=\u20091.05, 95%CI\u2009=\u20090.98-1.14; p\u2009=\u20090.178), not observing differences between the categories of explanatory variables. Caloric restriction was not associated with MD in our study.nnCONCLUSIONS: This is the first study exploring the association between MD and the effect of caloric deficit or excessive caloric consumption according to the energy requirements of each woman. Although caloric restriction does not seem to affect breast density, a caloric intake above predicted levels seems to increase this phenotype.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1016\/j.maturitas.2018.09.006<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Guillam\u00f3 E, Cobo-Calvo \u00c1, Oviedo GR, Travier N, \u00c1lamo J, Ni\u00f1o-Mendez OA, Mart\u00ednez-Yelamos A, Mart\u00ednez-Yelamos S, Javierre C. <\/p>Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study. Journal Article<\/span> <\/p>J Sports Sci Med. <\/span>2018<\/span>;17<\/span>:426\u2013436<\/span>.<\/p>Abstract<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30116116,\r\ntitle = {Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study},\r\nauthor = {Guillam\u00f3 E and Cobo-Calvo \u00c1 and Oviedo GR and Travier N and \u00c1lamo J and Ni\u00f1o-Mendez OA and Mart\u00ednez-Yelamos A and Mart\u00ednez-Yelamos S and Javierre C},\r\nissn = {1303-2968},\r\nyear = {2018},\r\ndate = {2018-09-01},\r\njournal = {J Sports Sci Med},\r\nvolume = {17},\r\nnumber = {3},\r\npages = {426--436},\r\nabstract = {Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.<\/div>Close<\/a><\/p><\/div><\/div><\/div> Travier N, Buckland G, Vendrell JJ, Fernandez-Veledo S, Peir\u00f3 I, Del Barco S, Pernas S, Zamora E, Bellet M, Margeli M, Cirauqui B, Mu\u00f1oz M, Tusquets I, Arcusa A, Javierre C, Moreno F, Rodriguez A, Agudo A. <\/p>Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors<\/a>. Journal Article<\/span> <\/p>Eur J Cancer Care (Engl). <\/span>2018<\/span>;27<\/span>:e12861<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29869823,\r\ntitle = {Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors},\r\nauthor = {Travier N and Buckland G and Vendrell JJ and Fernandez-Veledo S and Peir\u00f3 I and Del Barco S and Pernas S and Zamora E and Bellet M and Margeli M and Cirauqui B and Mu\u00f1oz M and Tusquets I and Arcusa A and Javierre C and Moreno F and Rodriguez A and Agudo A},\r\ndoi = {10.1111\/ecc.12861},\r\nissn = {1365-2354},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Eur J Cancer Care (Engl)},\r\nvolume = {27},\r\nnumber = {4},\r\npages = {e12861},\r\nabstract = {Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/ecc.12861<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Rom\u00e1n M, Caicoya M, Espin\u00e0s J, Sala M, Tor\u00e1-Rocamora I, Quinta MJ, Vernet M, Saladi\u00e9 F, Romero A, S\u00e1nchez M, Bar\u00e9 M, Vidal C, Servitja S, Natal C, Corominas J, Ferrer J, Rodr\u00edguez-Arana A, Castells X, study BELE Project group. <\/p>Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain<\/a>. Journal Article<\/span> <\/p>Breast J. <\/span>2018<\/span>;24<\/span>:509\u2013518<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Maturitas. <\/span>2018<\/span>;117<\/span>:57\u201363<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30314562,\r\ntitle = {Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study},\r\nauthor = {Del Pozo MDP and Castell\u00f3 A and Vidal C and Salas-Trejo D and S\u00e1nchez-Contador C and Pedraz-Pingarr\u00f3n C and Moreo P and Santamari\u00f1a C and Ederra M and Llobet R and Vioque J and P\u00e9rez-G\u00f3mez B and Poll\u00e1n M and Lope V},\r\ndoi = {10.1016\/j.maturitas.2018.09.006},\r\nissn = {1873-4111},\r\nyear = {2018},\r\ndate = {2018-11-01},\r\njournal = {Maturitas},\r\nvolume = {117},\r\npages = {57--63},\r\nabstract = {OBJECTIVES: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women.nnSTUDY DESIGN: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey. Predicted calories were calculated using linear regression models, including the basal metabolic rate and physical activity as explanatory variables. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using center-specific mixed ordinal logistic regression models, adjusted for age, menopausal status, body mass index, parity, tobacco use, family history of breast cancer, previous biopsies, age at menarche and adherence to a Western diet.nnMAIN OUTCOME MEASURE: Mammographic density.nnRESULTS: Those women with an excessive caloric intake (>40% above predicted) presented higher MD (OR\u2009=\u20091.41, 95%CI\u2009=\u20090.97-2.03; p\u2009=\u20090.070). For every 20% increase in relative caloric consumption the probability of having higher MD increased by 5% (OR\u2009=\u20091.05, 95%CI\u2009=\u20090.98-1.14; p\u2009=\u20090.178), not observing differences between the categories of explanatory variables. Caloric restriction was not associated with MD in our study.nnCONCLUSIONS: This is the first study exploring the association between MD and the effect of caloric deficit or excessive caloric consumption according to the energy requirements of each woman. Although caloric restriction does not seem to affect breast density, a caloric intake above predicted levels seems to increase this phenotype.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>OBJECTIVES: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women.nnSTUDY DESIGN: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey. Predicted calories were calculated using linear regression models, including the basal metabolic rate and physical activity as explanatory variables. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using center-specific mixed ordinal logistic regression models, adjusted for age, menopausal status, body mass index, parity, tobacco use, family history of breast cancer, previous biopsies, age at menarche and adherence to a Western diet.nnMAIN OUTCOME MEASURE: Mammographic density.nnRESULTS: Those women with an excessive caloric intake (>40% above predicted) presented higher MD (OR\u2009=\u20091.41, 95%CI\u2009=\u20090.97-2.03; p\u2009=\u20090.070). For every 20% increase in relative caloric consumption the probability of having higher MD increased by 5% (OR\u2009=\u20091.05, 95%CI\u2009=\u20090.98-1.14; p\u2009=\u20090.178), not observing differences between the categories of explanatory variables. Caloric restriction was not associated with MD in our study.nnCONCLUSIONS: This is the first study exploring the association between MD and the effect of caloric deficit or excessive caloric consumption according to the energy requirements of each woman. Although caloric restriction does not seem to affect breast density, a caloric intake above predicted levels seems to increase this phenotype.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1016\/j.maturitas.2018.09.006<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Guillam\u00f3 E, Cobo-Calvo \u00c1, Oviedo GR, Travier N, \u00c1lamo J, Ni\u00f1o-Mendez OA, Mart\u00ednez-Yelamos A, Mart\u00ednez-Yelamos S, Javierre C. <\/p>Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study. Journal Article<\/span> <\/p>J Sports Sci Med. <\/span>2018<\/span>;17<\/span>:426\u2013436<\/span>.<\/p>Abstract<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30116116,\r\ntitle = {Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study},\r\nauthor = {Guillam\u00f3 E and Cobo-Calvo \u00c1 and Oviedo GR and Travier N and \u00c1lamo J and Ni\u00f1o-Mendez OA and Mart\u00ednez-Yelamos A and Mart\u00ednez-Yelamos S and Javierre C},\r\nissn = {1303-2968},\r\nyear = {2018},\r\ndate = {2018-09-01},\r\njournal = {J Sports Sci Med},\r\nvolume = {17},\r\nnumber = {3},\r\npages = {426--436},\r\nabstract = {Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.<\/div>Close<\/a><\/p><\/div><\/div><\/div> Travier N, Buckland G, Vendrell JJ, Fernandez-Veledo S, Peir\u00f3 I, Del Barco S, Pernas S, Zamora E, Bellet M, Margeli M, Cirauqui B, Mu\u00f1oz M, Tusquets I, Arcusa A, Javierre C, Moreno F, Rodriguez A, Agudo A. <\/p>Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors<\/a>. Journal Article<\/span> <\/p>Eur J Cancer Care (Engl). <\/span>2018<\/span>;27<\/span>:e12861<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29869823,\r\ntitle = {Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors},\r\nauthor = {Travier N and Buckland G and Vendrell JJ and Fernandez-Veledo S and Peir\u00f3 I and Del Barco S and Pernas S and Zamora E and Bellet M and Margeli M and Cirauqui B and Mu\u00f1oz M and Tusquets I and Arcusa A and Javierre C and Moreno F and Rodriguez A and Agudo A},\r\ndoi = {10.1111\/ecc.12861},\r\nissn = {1365-2354},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Eur J Cancer Care (Engl)},\r\nvolume = {27},\r\nnumber = {4},\r\npages = {e12861},\r\nabstract = {Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/ecc.12861<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Rom\u00e1n M, Caicoya M, Espin\u00e0s J, Sala M, Tor\u00e1-Rocamora I, Quinta MJ, Vernet M, Saladi\u00e9 F, Romero A, S\u00e1nchez M, Bar\u00e9 M, Vidal C, Servitja S, Natal C, Corominas J, Ferrer J, Rodr\u00edguez-Arana A, Castells X, study BELE Project group. <\/p>Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain<\/a>. Journal Article<\/span> <\/p>Breast J. <\/span>2018<\/span>;24<\/span>:509\u2013518<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30314562,\r\ntitle = {Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study},\r\nauthor = {Del Pozo MDP and Castell\u00f3 A and Vidal C and Salas-Trejo D and S\u00e1nchez-Contador C and Pedraz-Pingarr\u00f3n C and Moreo P and Santamari\u00f1a C and Ederra M and Llobet R and Vioque J and P\u00e9rez-G\u00f3mez B and Poll\u00e1n M and Lope V},\r\ndoi = {10.1016\/j.maturitas.2018.09.006},\r\nissn = {1873-4111},\r\nyear = {2018},\r\ndate = {2018-11-01},\r\njournal = {Maturitas},\r\nvolume = {117},\r\npages = {57--63},\r\nabstract = {OBJECTIVES: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women.nnSTUDY DESIGN: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey. Predicted calories were calculated using linear regression models, including the basal metabolic rate and physical activity as explanatory variables. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using center-specific mixed ordinal logistic regression models, adjusted for age, menopausal status, body mass index, parity, tobacco use, family history of breast cancer, previous biopsies, age at menarche and adherence to a Western diet.nnMAIN OUTCOME MEASURE: Mammographic density.nnRESULTS: Those women with an excessive caloric intake (>40% above predicted) presented higher MD (OR\u2009=\u20091.41, 95%CI\u2009=\u20090.97-2.03; p\u2009=\u20090.070). For every 20% increase in relative caloric consumption the probability of having higher MD increased by 5% (OR\u2009=\u20091.05, 95%CI\u2009=\u20090.98-1.14; p\u2009=\u20090.178), not observing differences between the categories of explanatory variables. Caloric restriction was not associated with MD in our study.nnCONCLUSIONS: This is the first study exploring the association between MD and the effect of caloric deficit or excessive caloric consumption according to the energy requirements of each woman. Although caloric restriction does not seem to affect breast density, a caloric intake above predicted levels seems to increase this phenotype.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>OBJECTIVES: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women.nnSTUDY DESIGN: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey. Predicted calories were calculated using linear regression models, including the basal metabolic rate and physical activity as explanatory variables. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using center-specific mixed ordinal logistic regression models, adjusted for age, menopausal status, body mass index, parity, tobacco use, family history of breast cancer, previous biopsies, age at menarche and adherence to a Western diet.nnMAIN OUTCOME MEASURE: Mammographic density.nnRESULTS: Those women with an excessive caloric intake (>40% above predicted) presented higher MD (OR\u2009=\u20091.41, 95%CI\u2009=\u20090.97-2.03; p\u2009=\u20090.070). For every 20% increase in relative caloric consumption the probability of having higher MD increased by 5% (OR\u2009=\u20091.05, 95%CI\u2009=\u20090.98-1.14; p\u2009=\u20090.178), not observing differences between the categories of explanatory variables. Caloric restriction was not associated with MD in our study.nnCONCLUSIONS: This is the first study exploring the association between MD and the effect of caloric deficit or excessive caloric consumption according to the energy requirements of each woman. Although caloric restriction does not seem to affect breast density, a caloric intake above predicted levels seems to increase this phenotype.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1016\/j.maturitas.2018.09.006<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Guillam\u00f3 E, Cobo-Calvo \u00c1, Oviedo GR, Travier N, \u00c1lamo J, Ni\u00f1o-Mendez OA, Mart\u00ednez-Yelamos A, Mart\u00ednez-Yelamos S, Javierre C. <\/p>Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study. Journal Article<\/span> <\/p>J Sports Sci Med. <\/span>2018<\/span>;17<\/span>:426\u2013436<\/span>.<\/p>Abstract<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30116116,\r\ntitle = {Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study},\r\nauthor = {Guillam\u00f3 E and Cobo-Calvo \u00c1 and Oviedo GR and Travier N and \u00c1lamo J and Ni\u00f1o-Mendez OA and Mart\u00ednez-Yelamos A and Mart\u00ednez-Yelamos S and Javierre C},\r\nissn = {1303-2968},\r\nyear = {2018},\r\ndate = {2018-09-01},\r\njournal = {J Sports Sci Med},\r\nvolume = {17},\r\nnumber = {3},\r\npages = {426--436},\r\nabstract = {Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.<\/div>Close<\/a><\/p><\/div><\/div><\/div> Travier N, Buckland G, Vendrell JJ, Fernandez-Veledo S, Peir\u00f3 I, Del Barco S, Pernas S, Zamora E, Bellet M, Margeli M, Cirauqui B, Mu\u00f1oz M, Tusquets I, Arcusa A, Javierre C, Moreno F, Rodriguez A, Agudo A. <\/p>Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors<\/a>. Journal Article<\/span> <\/p>Eur J Cancer Care (Engl). <\/span>2018<\/span>;27<\/span>:e12861<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29869823,\r\ntitle = {Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors},\r\nauthor = {Travier N and Buckland G and Vendrell JJ and Fernandez-Veledo S and Peir\u00f3 I and Del Barco S and Pernas S and Zamora E and Bellet M and Margeli M and Cirauqui B and Mu\u00f1oz M and Tusquets I and Arcusa A and Javierre C and Moreno F and Rodriguez A and Agudo A},\r\ndoi = {10.1111\/ecc.12861},\r\nissn = {1365-2354},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Eur J Cancer Care (Engl)},\r\nvolume = {27},\r\nnumber = {4},\r\npages = {e12861},\r\nabstract = {Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/ecc.12861<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Rom\u00e1n M, Caicoya M, Espin\u00e0s J, Sala M, Tor\u00e1-Rocamora I, Quinta MJ, Vernet M, Saladi\u00e9 F, Romero A, S\u00e1nchez M, Bar\u00e9 M, Vidal C, Servitja S, Natal C, Corominas J, Ferrer J, Rodr\u00edguez-Arana A, Castells X, study BELE Project group. <\/p>Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain<\/a>. Journal Article<\/span> <\/p>Breast J. <\/span>2018<\/span>;24<\/span>:509\u2013518<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
@article{pmid30314562,\r\ntitle = {Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study},\r\nauthor = {Del Pozo MDP and Castell\u00f3 A and Vidal C and Salas-Trejo D and S\u00e1nchez-Contador C and Pedraz-Pingarr\u00f3n C and Moreo P and Santamari\u00f1a C and Ederra M and Llobet R and Vioque J and P\u00e9rez-G\u00f3mez B and Poll\u00e1n M and Lope V},\r\ndoi = {10.1016\/j.maturitas.2018.09.006},\r\nissn = {1873-4111},\r\nyear = {2018},\r\ndate = {2018-11-01},\r\njournal = {Maturitas},\r\nvolume = {117},\r\npages = {57--63},\r\nabstract = {OBJECTIVES: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women.nnSTUDY DESIGN: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey. Predicted calories were calculated using linear regression models, including the basal metabolic rate and physical activity as explanatory variables. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using center-specific mixed ordinal logistic regression models, adjusted for age, menopausal status, body mass index, parity, tobacco use, family history of breast cancer, previous biopsies, age at menarche and adherence to a Western diet.nnMAIN OUTCOME MEASURE: Mammographic density.nnRESULTS: Those women with an excessive caloric intake (>40% above predicted) presented higher MD (OR\u2009=\u20091.41, 95%CI\u2009=\u20090.97-2.03; p\u2009=\u20090.070). For every 20% increase in relative caloric consumption the probability of having higher MD increased by 5% (OR\u2009=\u20091.05, 95%CI\u2009=\u20090.98-1.14; p\u2009=\u20090.178), not observing differences between the categories of explanatory variables. Caloric restriction was not associated with MD in our study.nnCONCLUSIONS: This is the first study exploring the association between MD and the effect of caloric deficit or excessive caloric consumption according to the energy requirements of each woman. Although caloric restriction does not seem to affect breast density, a caloric intake above predicted levels seems to increase this phenotype.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>OBJECTIVES: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women.nnSTUDY DESIGN: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey. Predicted calories were calculated using linear regression models, including the basal metabolic rate and physical activity as explanatory variables. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using center-specific mixed ordinal logistic regression models, adjusted for age, menopausal status, body mass index, parity, tobacco use, family history of breast cancer, previous biopsies, age at menarche and adherence to a Western diet.nnMAIN OUTCOME MEASURE: Mammographic density.nnRESULTS: Those women with an excessive caloric intake (>40% above predicted) presented higher MD (OR\u2009=\u20091.41, 95%CI\u2009=\u20090.97-2.03; p\u2009=\u20090.070). For every 20% increase in relative caloric consumption the probability of having higher MD increased by 5% (OR\u2009=\u20091.05, 95%CI\u2009=\u20090.98-1.14; p\u2009=\u20090.178), not observing differences between the categories of explanatory variables. Caloric restriction was not associated with MD in our study.nnCONCLUSIONS: This is the first study exploring the association between MD and the effect of caloric deficit or excessive caloric consumption according to the energy requirements of each woman. Although caloric restriction does not seem to affect breast density, a caloric intake above predicted levels seems to increase this phenotype.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1016\/j.maturitas.2018.09.006<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Guillam\u00f3 E, Cobo-Calvo \u00c1, Oviedo GR, Travier N, \u00c1lamo J, Ni\u00f1o-Mendez OA, Mart\u00ednez-Yelamos A, Mart\u00ednez-Yelamos S, Javierre C. <\/p>Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study. Journal Article<\/span> <\/p>J Sports Sci Med. <\/span>2018<\/span>;17<\/span>:426\u2013436<\/span>.<\/p>Abstract<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30116116,\r\ntitle = {Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study},\r\nauthor = {Guillam\u00f3 E and Cobo-Calvo \u00c1 and Oviedo GR and Travier N and \u00c1lamo J and Ni\u00f1o-Mendez OA and Mart\u00ednez-Yelamos A and Mart\u00ednez-Yelamos S and Javierre C},\r\nissn = {1303-2968},\r\nyear = {2018},\r\ndate = {2018-09-01},\r\njournal = {J Sports Sci Med},\r\nvolume = {17},\r\nnumber = {3},\r\npages = {426--436},\r\nabstract = {Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.<\/div>Close<\/a><\/p><\/div><\/div><\/div> Travier N, Buckland G, Vendrell JJ, Fernandez-Veledo S, Peir\u00f3 I, Del Barco S, Pernas S, Zamora E, Bellet M, Margeli M, Cirauqui B, Mu\u00f1oz M, Tusquets I, Arcusa A, Javierre C, Moreno F, Rodriguez A, Agudo A. <\/p>Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors<\/a>. Journal Article<\/span> <\/p>Eur J Cancer Care (Engl). <\/span>2018<\/span>;27<\/span>:e12861<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29869823,\r\ntitle = {Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors},\r\nauthor = {Travier N and Buckland G and Vendrell JJ and Fernandez-Veledo S and Peir\u00f3 I and Del Barco S and Pernas S and Zamora E and Bellet M and Margeli M and Cirauqui B and Mu\u00f1oz M and Tusquets I and Arcusa A and Javierre C and Moreno F and Rodriguez A and Agudo A},\r\ndoi = {10.1111\/ecc.12861},\r\nissn = {1365-2354},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Eur J Cancer Care (Engl)},\r\nvolume = {27},\r\nnumber = {4},\r\npages = {e12861},\r\nabstract = {Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/ecc.12861<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Rom\u00e1n M, Caicoya M, Espin\u00e0s J, Sala M, Tor\u00e1-Rocamora I, Quinta MJ, Vernet M, Saladi\u00e9 F, Romero A, S\u00e1nchez M, Bar\u00e9 M, Vidal C, Servitja S, Natal C, Corominas J, Ferrer J, Rodr\u00edguez-Arana A, Castells X, study BELE Project group. <\/p>Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain<\/a>. Journal Article<\/span> <\/p>Breast J. <\/span>2018<\/span>;24<\/span>:509\u2013518<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Close<\/a><\/p><\/div>OBJECTIVES: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women.nnSTUDY DESIGN: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey. Predicted calories were calculated using linear regression models, including the basal metabolic rate and physical activity as explanatory variables. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using center-specific mixed ordinal logistic regression models, adjusted for age, menopausal status, body mass index, parity, tobacco use, family history of breast cancer, previous biopsies, age at menarche and adherence to a Western diet.nnMAIN OUTCOME MEASURE: Mammographic density.nnRESULTS: Those women with an excessive caloric intake (>40% above predicted) presented higher MD (OR\u2009=\u20091.41, 95%CI\u2009=\u20090.97-2.03; p\u2009=\u20090.070). For every 20% increase in relative caloric consumption the probability of having higher MD increased by 5% (OR\u2009=\u20091.05, 95%CI\u2009=\u20090.98-1.14; p\u2009=\u20090.178), not observing differences between the categories of explanatory variables. Caloric restriction was not associated with MD in our study.nnCONCLUSIONS: This is the first study exploring the association between MD and the effect of caloric deficit or excessive caloric consumption according to the energy requirements of each woman. Although caloric restriction does not seem to affect breast density, a caloric intake above predicted levels seems to increase this phenotype.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1016\/j.maturitas.2018.09.006<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Guillam\u00f3 E, Cobo-Calvo \u00c1, Oviedo GR, Travier N, \u00c1lamo J, Ni\u00f1o-Mendez OA, Mart\u00ednez-Yelamos A, Mart\u00ednez-Yelamos S, Javierre C. <\/p>Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study. Journal Article<\/span> <\/p>J Sports Sci Med. <\/span>2018<\/span>;17<\/span>:426\u2013436<\/span>.<\/p>Abstract<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30116116,\r\ntitle = {Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study},\r\nauthor = {Guillam\u00f3 E and Cobo-Calvo \u00c1 and Oviedo GR and Travier N and \u00c1lamo J and Ni\u00f1o-Mendez OA and Mart\u00ednez-Yelamos A and Mart\u00ednez-Yelamos S and Javierre C},\r\nissn = {1303-2968},\r\nyear = {2018},\r\ndate = {2018-09-01},\r\njournal = {J Sports Sci Med},\r\nvolume = {17},\r\nnumber = {3},\r\npages = {426--436},\r\nabstract = {Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.<\/div>Close<\/a><\/p><\/div><\/div><\/div> Travier N, Buckland G, Vendrell JJ, Fernandez-Veledo S, Peir\u00f3 I, Del Barco S, Pernas S, Zamora E, Bellet M, Margeli M, Cirauqui B, Mu\u00f1oz M, Tusquets I, Arcusa A, Javierre C, Moreno F, Rodriguez A, Agudo A. <\/p>Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors<\/a>. Journal Article<\/span> <\/p>Eur J Cancer Care (Engl). <\/span>2018<\/span>;27<\/span>:e12861<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29869823,\r\ntitle = {Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors},\r\nauthor = {Travier N and Buckland G and Vendrell JJ and Fernandez-Veledo S and Peir\u00f3 I and Del Barco S and Pernas S and Zamora E and Bellet M and Margeli M and Cirauqui B and Mu\u00f1oz M and Tusquets I and Arcusa A and Javierre C and Moreno F and Rodriguez A and Agudo A},\r\ndoi = {10.1111\/ecc.12861},\r\nissn = {1365-2354},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Eur J Cancer Care (Engl)},\r\nvolume = {27},\r\nnumber = {4},\r\npages = {e12861},\r\nabstract = {Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/ecc.12861<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Rom\u00e1n M, Caicoya M, Espin\u00e0s J, Sala M, Tor\u00e1-Rocamora I, Quinta MJ, Vernet M, Saladi\u00e9 F, Romero A, S\u00e1nchez M, Bar\u00e9 M, Vidal C, Servitja S, Natal C, Corominas J, Ferrer J, Rodr\u00edguez-Arana A, Castells X, study BELE Project group. <\/p>Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain<\/a>. Journal Article<\/span> <\/p>Breast J. <\/span>2018<\/span>;24<\/span>:509\u2013518<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Close<\/a><\/p><\/div><\/i>doi:10.1016\/j.maturitas.2018.09.006<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Guillam\u00f3 E, Cobo-Calvo \u00c1, Oviedo GR, Travier N, \u00c1lamo J, Ni\u00f1o-Mendez OA, Mart\u00ednez-Yelamos A, Mart\u00ednez-Yelamos S, Javierre C. <\/p>Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study. Journal Article<\/span> <\/p>J Sports Sci Med. <\/span>2018<\/span>;17<\/span>:426\u2013436<\/span>.<\/p>Abstract<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30116116,\r\ntitle = {Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study},\r\nauthor = {Guillam\u00f3 E and Cobo-Calvo \u00c1 and Oviedo GR and Travier N and \u00c1lamo J and Ni\u00f1o-Mendez OA and Mart\u00ednez-Yelamos A and Mart\u00ednez-Yelamos S and Javierre C},\r\nissn = {1303-2968},\r\nyear = {2018},\r\ndate = {2018-09-01},\r\njournal = {J Sports Sci Med},\r\nvolume = {17},\r\nnumber = {3},\r\npages = {426--436},\r\nabstract = {Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.<\/div>Close<\/a><\/p><\/div><\/div><\/div> Travier N, Buckland G, Vendrell JJ, Fernandez-Veledo S, Peir\u00f3 I, Del Barco S, Pernas S, Zamora E, Bellet M, Margeli M, Cirauqui B, Mu\u00f1oz M, Tusquets I, Arcusa A, Javierre C, Moreno F, Rodriguez A, Agudo A. <\/p>Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors<\/a>. Journal Article<\/span> <\/p>Eur J Cancer Care (Engl). <\/span>2018<\/span>;27<\/span>:e12861<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29869823,\r\ntitle = {Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors},\r\nauthor = {Travier N and Buckland G and Vendrell JJ and Fernandez-Veledo S and Peir\u00f3 I and Del Barco S and Pernas S and Zamora E and Bellet M and Margeli M and Cirauqui B and Mu\u00f1oz M and Tusquets I and Arcusa A and Javierre C and Moreno F and Rodriguez A and Agudo A},\r\ndoi = {10.1111\/ecc.12861},\r\nissn = {1365-2354},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Eur J Cancer Care (Engl)},\r\nvolume = {27},\r\nnumber = {4},\r\npages = {e12861},\r\nabstract = {Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/ecc.12861<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Rom\u00e1n M, Caicoya M, Espin\u00e0s J, Sala M, Tor\u00e1-Rocamora I, Quinta MJ, Vernet M, Saladi\u00e9 F, Romero A, S\u00e1nchez M, Bar\u00e9 M, Vidal C, Servitja S, Natal C, Corominas J, Ferrer J, Rodr\u00edguez-Arana A, Castells X, study BELE Project group. <\/p>Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain<\/a>. Journal Article<\/span> <\/p>Breast J. <\/span>2018<\/span>;24<\/span>:509\u2013518<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Close<\/a><\/p><\/div><\/div><\/div> Guillam\u00f3 E, Cobo-Calvo \u00c1, Oviedo GR, Travier N, \u00c1lamo J, Ni\u00f1o-Mendez OA, Mart\u00ednez-Yelamos A, Mart\u00ednez-Yelamos S, Javierre C. <\/p>Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study. Journal Article<\/span> <\/p>J Sports Sci Med. <\/span>2018<\/span>;17<\/span>:426\u2013436<\/span>.<\/p>Abstract<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30116116,\r\ntitle = {Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study},\r\nauthor = {Guillam\u00f3 E and Cobo-Calvo \u00c1 and Oviedo GR and Travier N and \u00c1lamo J and Ni\u00f1o-Mendez OA and Mart\u00ednez-Yelamos A and Mart\u00ednez-Yelamos S and Javierre C},\r\nissn = {1303-2968},\r\nyear = {2018},\r\ndate = {2018-09-01},\r\njournal = {J Sports Sci Med},\r\nvolume = {17},\r\nnumber = {3},\r\npages = {426--436},\r\nabstract = {Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.<\/div>Close<\/a><\/p><\/div><\/div><\/div> Travier N, Buckland G, Vendrell JJ, Fernandez-Veledo S, Peir\u00f3 I, Del Barco S, Pernas S, Zamora E, Bellet M, Margeli M, Cirauqui B, Mu\u00f1oz M, Tusquets I, Arcusa A, Javierre C, Moreno F, Rodriguez A, Agudo A. <\/p>Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors<\/a>. Journal Article<\/span> <\/p>Eur J Cancer Care (Engl). <\/span>2018<\/span>;27<\/span>:e12861<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29869823,\r\ntitle = {Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors},\r\nauthor = {Travier N and Buckland G and Vendrell JJ and Fernandez-Veledo S and Peir\u00f3 I and Del Barco S and Pernas S and Zamora E and Bellet M and Margeli M and Cirauqui B and Mu\u00f1oz M and Tusquets I and Arcusa A and Javierre C and Moreno F and Rodriguez A and Agudo A},\r\ndoi = {10.1111\/ecc.12861},\r\nissn = {1365-2354},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Eur J Cancer Care (Engl)},\r\nvolume = {27},\r\nnumber = {4},\r\npages = {e12861},\r\nabstract = {Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/ecc.12861<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Rom\u00e1n M, Caicoya M, Espin\u00e0s J, Sala M, Tor\u00e1-Rocamora I, Quinta MJ, Vernet M, Saladi\u00e9 F, Romero A, S\u00e1nchez M, Bar\u00e9 M, Vidal C, Servitja S, Natal C, Corominas J, Ferrer J, Rodr\u00edguez-Arana A, Castells X, study BELE Project group. <\/p>Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain<\/a>. Journal Article<\/span> <\/p>Breast J. <\/span>2018<\/span>;24<\/span>:509\u2013518<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Guillam\u00f3 E, Cobo-Calvo \u00c1, Oviedo GR, Travier N, \u00c1lamo J, Ni\u00f1o-Mendez OA, Mart\u00ednez-Yelamos A, Mart\u00ednez-Yelamos S, Javierre C. <\/p>
Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study. Journal Article<\/span> <\/p>J Sports Sci Med. <\/span>2018<\/span>;17<\/span>:426\u2013436<\/span>.<\/p>Abstract<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30116116,\r\ntitle = {Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study},\r\nauthor = {Guillam\u00f3 E and Cobo-Calvo \u00c1 and Oviedo GR and Travier N and \u00c1lamo J and Ni\u00f1o-Mendez OA and Mart\u00ednez-Yelamos A and Mart\u00ednez-Yelamos S and Javierre C},\r\nissn = {1303-2968},\r\nyear = {2018},\r\ndate = {2018-09-01},\r\njournal = {J Sports Sci Med},\r\nvolume = {17},\r\nnumber = {3},\r\npages = {426--436},\r\nabstract = {Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.<\/div>Close<\/a><\/p><\/div><\/div><\/div> Travier N, Buckland G, Vendrell JJ, Fernandez-Veledo S, Peir\u00f3 I, Del Barco S, Pernas S, Zamora E, Bellet M, Margeli M, Cirauqui B, Mu\u00f1oz M, Tusquets I, Arcusa A, Javierre C, Moreno F, Rodriguez A, Agudo A. <\/p>Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors<\/a>. Journal Article<\/span> <\/p>Eur J Cancer Care (Engl). <\/span>2018<\/span>;27<\/span>:e12861<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29869823,\r\ntitle = {Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors},\r\nauthor = {Travier N and Buckland G and Vendrell JJ and Fernandez-Veledo S and Peir\u00f3 I and Del Barco S and Pernas S and Zamora E and Bellet M and Margeli M and Cirauqui B and Mu\u00f1oz M and Tusquets I and Arcusa A and Javierre C and Moreno F and Rodriguez A and Agudo A},\r\ndoi = {10.1111\/ecc.12861},\r\nissn = {1365-2354},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Eur J Cancer Care (Engl)},\r\nvolume = {27},\r\nnumber = {4},\r\npages = {e12861},\r\nabstract = {Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/ecc.12861<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Rom\u00e1n M, Caicoya M, Espin\u00e0s J, Sala M, Tor\u00e1-Rocamora I, Quinta MJ, Vernet M, Saladi\u00e9 F, Romero A, S\u00e1nchez M, Bar\u00e9 M, Vidal C, Servitja S, Natal C, Corominas J, Ferrer J, Rodr\u00edguez-Arana A, Castells X, study BELE Project group. <\/p>Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain<\/a>. Journal Article<\/span> <\/p>Breast J. <\/span>2018<\/span>;24<\/span>:509\u2013518<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
J Sports Sci Med. <\/span>2018<\/span>;17<\/span>:426\u2013436<\/span>.<\/p>Abstract<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30116116,\r\ntitle = {Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study},\r\nauthor = {Guillam\u00f3 E and Cobo-Calvo \u00c1 and Oviedo GR and Travier N and \u00c1lamo J and Ni\u00f1o-Mendez OA and Mart\u00ednez-Yelamos A and Mart\u00ednez-Yelamos S and Javierre C},\r\nissn = {1303-2968},\r\nyear = {2018},\r\ndate = {2018-09-01},\r\njournal = {J Sports Sci Med},\r\nvolume = {17},\r\nnumber = {3},\r\npages = {426--436},\r\nabstract = {Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.<\/div>Close<\/a><\/p><\/div><\/div><\/div> Travier N, Buckland G, Vendrell JJ, Fernandez-Veledo S, Peir\u00f3 I, Del Barco S, Pernas S, Zamora E, Bellet M, Margeli M, Cirauqui B, Mu\u00f1oz M, Tusquets I, Arcusa A, Javierre C, Moreno F, Rodriguez A, Agudo A. <\/p>Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors<\/a>. Journal Article<\/span> <\/p>Eur J Cancer Care (Engl). <\/span>2018<\/span>;27<\/span>:e12861<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29869823,\r\ntitle = {Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors},\r\nauthor = {Travier N and Buckland G and Vendrell JJ and Fernandez-Veledo S and Peir\u00f3 I and Del Barco S and Pernas S and Zamora E and Bellet M and Margeli M and Cirauqui B and Mu\u00f1oz M and Tusquets I and Arcusa A and Javierre C and Moreno F and Rodriguez A and Agudo A},\r\ndoi = {10.1111\/ecc.12861},\r\nissn = {1365-2354},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Eur J Cancer Care (Engl)},\r\nvolume = {27},\r\nnumber = {4},\r\npages = {e12861},\r\nabstract = {Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/ecc.12861<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Rom\u00e1n M, Caicoya M, Espin\u00e0s J, Sala M, Tor\u00e1-Rocamora I, Quinta MJ, Vernet M, Saladi\u00e9 F, Romero A, S\u00e1nchez M, Bar\u00e9 M, Vidal C, Servitja S, Natal C, Corominas J, Ferrer J, Rodr\u00edguez-Arana A, Castells X, study BELE Project group. <\/p>Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain<\/a>. Journal Article<\/span> <\/p>Breast J. <\/span>2018<\/span>;24<\/span>:509\u2013518<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Abstract<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid30116116,\r\ntitle = {Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study},\r\nauthor = {Guillam\u00f3 E and Cobo-Calvo \u00c1 and Oviedo GR and Travier N and \u00c1lamo J and Ni\u00f1o-Mendez OA and Mart\u00ednez-Yelamos A and Mart\u00ednez-Yelamos S and Javierre C},\r\nissn = {1303-2968},\r\nyear = {2018},\r\ndate = {2018-09-01},\r\njournal = {J Sports Sci Med},\r\nvolume = {17},\r\nnumber = {3},\r\npages = {426--436},\r\nabstract = {Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.<\/div>Close<\/a><\/p><\/div><\/div><\/div> Travier N, Buckland G, Vendrell JJ, Fernandez-Veledo S, Peir\u00f3 I, Del Barco S, Pernas S, Zamora E, Bellet M, Margeli M, Cirauqui B, Mu\u00f1oz M, Tusquets I, Arcusa A, Javierre C, Moreno F, Rodriguez A, Agudo A. <\/p>Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors<\/a>. Journal Article<\/span> <\/p>Eur J Cancer Care (Engl). <\/span>2018<\/span>;27<\/span>:e12861<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29869823,\r\ntitle = {Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors},\r\nauthor = {Travier N and Buckland G and Vendrell JJ and Fernandez-Veledo S and Peir\u00f3 I and Del Barco S and Pernas S and Zamora E and Bellet M and Margeli M and Cirauqui B and Mu\u00f1oz M and Tusquets I and Arcusa A and Javierre C and Moreno F and Rodriguez A and Agudo A},\r\ndoi = {10.1111\/ecc.12861},\r\nissn = {1365-2354},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Eur J Cancer Care (Engl)},\r\nvolume = {27},\r\nnumber = {4},\r\npages = {e12861},\r\nabstract = {Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/ecc.12861<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Rom\u00e1n M, Caicoya M, Espin\u00e0s J, Sala M, Tor\u00e1-Rocamora I, Quinta MJ, Vernet M, Saladi\u00e9 F, Romero A, S\u00e1nchez M, Bar\u00e9 M, Vidal C, Servitja S, Natal C, Corominas J, Ferrer J, Rodr\u00edguez-Arana A, Castells X, study BELE Project group. <\/p>Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain<\/a>. Journal Article<\/span> <\/p>Breast J. <\/span>2018<\/span>;24<\/span>:509\u2013518<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
@article{pmid30116116,\r\ntitle = {Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study},\r\nauthor = {Guillam\u00f3 E and Cobo-Calvo \u00c1 and Oviedo GR and Travier N and \u00c1lamo J and Ni\u00f1o-Mendez OA and Mart\u00ednez-Yelamos A and Mart\u00ednez-Yelamos S and Javierre C},\r\nissn = {1303-2968},\r\nyear = {2018},\r\ndate = {2018-09-01},\r\njournal = {J Sports Sci Med},\r\nvolume = {17},\r\nnumber = {3},\r\npages = {426--436},\r\nabstract = {Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.<\/div>Close<\/a><\/p><\/div><\/div><\/div> Travier N, Buckland G, Vendrell JJ, Fernandez-Veledo S, Peir\u00f3 I, Del Barco S, Pernas S, Zamora E, Bellet M, Margeli M, Cirauqui B, Mu\u00f1oz M, Tusquets I, Arcusa A, Javierre C, Moreno F, Rodriguez A, Agudo A. <\/p>Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors<\/a>. Journal Article<\/span> <\/p>Eur J Cancer Care (Engl). <\/span>2018<\/span>;27<\/span>:e12861<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29869823,\r\ntitle = {Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors},\r\nauthor = {Travier N and Buckland G and Vendrell JJ and Fernandez-Veledo S and Peir\u00f3 I and Del Barco S and Pernas S and Zamora E and Bellet M and Margeli M and Cirauqui B and Mu\u00f1oz M and Tusquets I and Arcusa A and Javierre C and Moreno F and Rodriguez A and Agudo A},\r\ndoi = {10.1111\/ecc.12861},\r\nissn = {1365-2354},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Eur J Cancer Care (Engl)},\r\nvolume = {27},\r\nnumber = {4},\r\npages = {e12861},\r\nabstract = {Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/ecc.12861<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Rom\u00e1n M, Caicoya M, Espin\u00e0s J, Sala M, Tor\u00e1-Rocamora I, Quinta MJ, Vernet M, Saladi\u00e9 F, Romero A, S\u00e1nchez M, Bar\u00e9 M, Vidal C, Servitja S, Natal C, Corominas J, Ferrer J, Rodr\u00edguez-Arana A, Castells X, study BELE Project group. <\/p>Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain<\/a>. Journal Article<\/span> <\/p>Breast J. <\/span>2018<\/span>;24<\/span>:509\u2013518<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Close<\/a><\/p><\/div>Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS. Twenty-nine participants with relapsing-remitting MS (RRMS) participated in this study. All of them were fully ambulatory and with minimal disability (Expanded Disability Status Scale <3), for at least the last six months. Participants selected to be part of a combined face-to-face plus home exercise group (CFTFG; n = 8); a self-applied home-based exercise group (HG; n = 11) or a control group (CG; n = 10). A total of 23 participants completed the protocol (79.3%), of which 8 participants (100%) from the CFTFG, 7 (63.6%) from the HG and 8 (80%) from the CG. During the first 20-weeks of training, adherence from the CFTFG reached 77.5% and from the HG reached 50 %. During the second 20-weeks of training, adherence from the CFTFG reached 62.5% and from the HG reached 45.4%. After 20-weeks of training, a significant improvement in the absolute VO peak and in the 30-second sit to stand test was observed in the CFTFG (all < .05). This study confirms that offering a 40-week structured exercise programme to a group of fully ambulatory and minimally disabled persons with RRMS is feasible and safe. Any adverse event related to the trial was reported by the participants.<\/div>Close<\/a><\/p><\/div><\/div><\/div> Travier N, Buckland G, Vendrell JJ, Fernandez-Veledo S, Peir\u00f3 I, Del Barco S, Pernas S, Zamora E, Bellet M, Margeli M, Cirauqui B, Mu\u00f1oz M, Tusquets I, Arcusa A, Javierre C, Moreno F, Rodriguez A, Agudo A. <\/p>Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors<\/a>. Journal Article<\/span> <\/p>Eur J Cancer Care (Engl). <\/span>2018<\/span>;27<\/span>:e12861<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29869823,\r\ntitle = {Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors},\r\nauthor = {Travier N and Buckland G and Vendrell JJ and Fernandez-Veledo S and Peir\u00f3 I and Del Barco S and Pernas S and Zamora E and Bellet M and Margeli M and Cirauqui B and Mu\u00f1oz M and Tusquets I and Arcusa A and Javierre C and Moreno F and Rodriguez A and Agudo A},\r\ndoi = {10.1111\/ecc.12861},\r\nissn = {1365-2354},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Eur J Cancer Care (Engl)},\r\nvolume = {27},\r\nnumber = {4},\r\npages = {e12861},\r\nabstract = {Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/ecc.12861<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Rom\u00e1n M, Caicoya M, Espin\u00e0s J, Sala M, Tor\u00e1-Rocamora I, Quinta MJ, Vernet M, Saladi\u00e9 F, Romero A, S\u00e1nchez M, Bar\u00e9 M, Vidal C, Servitja S, Natal C, Corominas J, Ferrer J, Rodr\u00edguez-Arana A, Castells X, study BELE Project group. <\/p>Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain<\/a>. Journal Article<\/span> <\/p>Breast J. <\/span>2018<\/span>;24<\/span>:509\u2013518<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Close<\/a><\/p><\/div><\/div><\/div> Travier N, Buckland G, Vendrell JJ, Fernandez-Veledo S, Peir\u00f3 I, Del Barco S, Pernas S, Zamora E, Bellet M, Margeli M, Cirauqui B, Mu\u00f1oz M, Tusquets I, Arcusa A, Javierre C, Moreno F, Rodriguez A, Agudo A. <\/p>Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors<\/a>. Journal Article<\/span> <\/p>Eur J Cancer Care (Engl). <\/span>2018<\/span>;27<\/span>:e12861<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29869823,\r\ntitle = {Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors},\r\nauthor = {Travier N and Buckland G and Vendrell JJ and Fernandez-Veledo S and Peir\u00f3 I and Del Barco S and Pernas S and Zamora E and Bellet M and Margeli M and Cirauqui B and Mu\u00f1oz M and Tusquets I and Arcusa A and Javierre C and Moreno F and Rodriguez A and Agudo A},\r\ndoi = {10.1111\/ecc.12861},\r\nissn = {1365-2354},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Eur J Cancer Care (Engl)},\r\nvolume = {27},\r\nnumber = {4},\r\npages = {e12861},\r\nabstract = {Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/ecc.12861<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Rom\u00e1n M, Caicoya M, Espin\u00e0s J, Sala M, Tor\u00e1-Rocamora I, Quinta MJ, Vernet M, Saladi\u00e9 F, Romero A, S\u00e1nchez M, Bar\u00e9 M, Vidal C, Servitja S, Natal C, Corominas J, Ferrer J, Rodr\u00edguez-Arana A, Castells X, study BELE Project group. <\/p>Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain<\/a>. Journal Article<\/span> <\/p>Breast J. <\/span>2018<\/span>;24<\/span>:509\u2013518<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Travier N, Buckland G, Vendrell JJ, Fernandez-Veledo S, Peir\u00f3 I, Del Barco S, Pernas S, Zamora E, Bellet M, Margeli M, Cirauqui B, Mu\u00f1oz M, Tusquets I, Arcusa A, Javierre C, Moreno F, Rodriguez A, Agudo A. <\/p>
Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors<\/a>. Journal Article<\/span> <\/p>Eur J Cancer Care (Engl). <\/span>2018<\/span>;27<\/span>:e12861<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29869823,\r\ntitle = {Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors},\r\nauthor = {Travier N and Buckland G and Vendrell JJ and Fernandez-Veledo S and Peir\u00f3 I and Del Barco S and Pernas S and Zamora E and Bellet M and Margeli M and Cirauqui B and Mu\u00f1oz M and Tusquets I and Arcusa A and Javierre C and Moreno F and Rodriguez A and Agudo A},\r\ndoi = {10.1111\/ecc.12861},\r\nissn = {1365-2354},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Eur J Cancer Care (Engl)},\r\nvolume = {27},\r\nnumber = {4},\r\npages = {e12861},\r\nabstract = {Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/ecc.12861<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Rom\u00e1n M, Caicoya M, Espin\u00e0s J, Sala M, Tor\u00e1-Rocamora I, Quinta MJ, Vernet M, Saladi\u00e9 F, Romero A, S\u00e1nchez M, Bar\u00e9 M, Vidal C, Servitja S, Natal C, Corominas J, Ferrer J, Rodr\u00edguez-Arana A, Castells X, study BELE Project group. <\/p>Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain<\/a>. Journal Article<\/span> <\/p>Breast J. <\/span>2018<\/span>;24<\/span>:509\u2013518<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Eur J Cancer Care (Engl). <\/span>2018<\/span>;27<\/span>:e12861<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29869823,\r\ntitle = {Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors},\r\nauthor = {Travier N and Buckland G and Vendrell JJ and Fernandez-Veledo S and Peir\u00f3 I and Del Barco S and Pernas S and Zamora E and Bellet M and Margeli M and Cirauqui B and Mu\u00f1oz M and Tusquets I and Arcusa A and Javierre C and Moreno F and Rodriguez A and Agudo A},\r\ndoi = {10.1111\/ecc.12861},\r\nissn = {1365-2354},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Eur J Cancer Care (Engl)},\r\nvolume = {27},\r\nnumber = {4},\r\npages = {e12861},\r\nabstract = {Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/ecc.12861<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Rom\u00e1n M, Caicoya M, Espin\u00e0s J, Sala M, Tor\u00e1-Rocamora I, Quinta MJ, Vernet M, Saladi\u00e9 F, Romero A, S\u00e1nchez M, Bar\u00e9 M, Vidal C, Servitja S, Natal C, Corominas J, Ferrer J, Rodr\u00edguez-Arana A, Castells X, study BELE Project group. <\/p>Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain<\/a>. Journal Article<\/span> <\/p>Breast J. <\/span>2018<\/span>;24<\/span>:509\u2013518<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29869823,\r\ntitle = {Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors},\r\nauthor = {Travier N and Buckland G and Vendrell JJ and Fernandez-Veledo S and Peir\u00f3 I and Del Barco S and Pernas S and Zamora E and Bellet M and Margeli M and Cirauqui B and Mu\u00f1oz M and Tusquets I and Arcusa A and Javierre C and Moreno F and Rodriguez A and Agudo A},\r\ndoi = {10.1111\/ecc.12861},\r\nissn = {1365-2354},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Eur J Cancer Care (Engl)},\r\nvolume = {27},\r\nnumber = {4},\r\npages = {e12861},\r\nabstract = {Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/ecc.12861<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Rom\u00e1n M, Caicoya M, Espin\u00e0s J, Sala M, Tor\u00e1-Rocamora I, Quinta MJ, Vernet M, Saladi\u00e9 F, Romero A, S\u00e1nchez M, Bar\u00e9 M, Vidal C, Servitja S, Natal C, Corominas J, Ferrer J, Rodr\u00edguez-Arana A, Castells X, study BELE Project group. <\/p>Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain<\/a>. Journal Article<\/span> <\/p>Breast J. <\/span>2018<\/span>;24<\/span>:509\u2013518<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
@article{pmid29869823,\r\ntitle = {Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors},\r\nauthor = {Travier N and Buckland G and Vendrell JJ and Fernandez-Veledo S and Peir\u00f3 I and Del Barco S and Pernas S and Zamora E and Bellet M and Margeli M and Cirauqui B and Mu\u00f1oz M and Tusquets I and Arcusa A and Javierre C and Moreno F and Rodriguez A and Agudo A},\r\ndoi = {10.1111\/ecc.12861},\r\nissn = {1365-2354},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Eur J Cancer Care (Engl)},\r\nvolume = {27},\r\nnumber = {4},\r\npages = {e12861},\r\nabstract = {Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/ecc.12861<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Rom\u00e1n M, Caicoya M, Espin\u00e0s J, Sala M, Tor\u00e1-Rocamora I, Quinta MJ, Vernet M, Saladi\u00e9 F, Romero A, S\u00e1nchez M, Bar\u00e9 M, Vidal C, Servitja S, Natal C, Corominas J, Ferrer J, Rodr\u00edguez-Arana A, Castells X, study BELE Project group. <\/p>Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain<\/a>. Journal Article<\/span> <\/p>Breast J. <\/span>2018<\/span>;24<\/span>:509\u2013518<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Close<\/a><\/p><\/div>Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer (BC) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre-post intervention study offering diet and exercise sessions over 12\u00a0weeks to 42 overweight\/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness (CRF) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed-rank tests and Spearman partial correlation coefficients were used to compare pre- and post-measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF. Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32\u00a0\u2264\u00a0|r|\u00a0\u2264\u00a00.55) with the decrease in body mass index and the increase in CRF. Diet and exercise interventions implemented in overweight\/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/ecc.12861<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Rom\u00e1n M, Caicoya M, Espin\u00e0s J, Sala M, Tor\u00e1-Rocamora I, Quinta MJ, Vernet M, Saladi\u00e9 F, Romero A, S\u00e1nchez M, Bar\u00e9 M, Vidal C, Servitja S, Natal C, Corominas J, Ferrer J, Rodr\u00edguez-Arana A, Castells X, study BELE Project group. <\/p>Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain<\/a>. Journal Article<\/span> <\/p>Breast J. <\/span>2018<\/span>;24<\/span>:509\u2013518<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Close<\/a><\/p><\/div><\/i>doi:10.1111\/ecc.12861<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Rom\u00e1n M, Caicoya M, Espin\u00e0s J, Sala M, Tor\u00e1-Rocamora I, Quinta MJ, Vernet M, Saladi\u00e9 F, Romero A, S\u00e1nchez M, Bar\u00e9 M, Vidal C, Servitja S, Natal C, Corominas J, Ferrer J, Rodr\u00edguez-Arana A, Castells X, study BELE Project group. <\/p>Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain<\/a>. Journal Article<\/span> <\/p>Breast J. <\/span>2018<\/span>;24<\/span>:509\u2013518<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Close<\/a><\/p><\/div><\/div><\/div> Rom\u00e1n M, Caicoya M, Espin\u00e0s J, Sala M, Tor\u00e1-Rocamora I, Quinta MJ, Vernet M, Saladi\u00e9 F, Romero A, S\u00e1nchez M, Bar\u00e9 M, Vidal C, Servitja S, Natal C, Corominas J, Ferrer J, Rodr\u00edguez-Arana A, Castells X, study BELE Project group. <\/p>Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain<\/a>. Journal Article<\/span> <\/p>Breast J. <\/span>2018<\/span>;24<\/span>:509\u2013518<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Rom\u00e1n M, Caicoya M, Espin\u00e0s J, Sala M, Tor\u00e1-Rocamora I, Quinta MJ, Vernet M, Saladi\u00e9 F, Romero A, S\u00e1nchez M, Bar\u00e9 M, Vidal C, Servitja S, Natal C, Corominas J, Ferrer J, Rodr\u00edguez-Arana A, Castells X, study BELE Project group. <\/p>
Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain<\/a>. Journal Article<\/span> <\/p>Breast J. <\/span>2018<\/span>;24<\/span>:509\u2013518<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Breast J. <\/span>2018<\/span>;24<\/span>:509\u2013518<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
@article{pmid29517151,\r\ntitle = {Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain},\r\nauthor = {Rom\u00e1n M and Caicoya M and Espin\u00e0s J and Sala M and Tor\u00e1-Rocamora I and Quinta MJ and Vernet M and Saladi\u00e9 F and Romero A and S\u00e1nchez M and Bar\u00e9 M and Vidal C and Servitja S and Natal C and Corominas J and Ferrer J and Rodr\u00edguez-Arana A and Castells X and BELE Project study group},\r\ndoi = {10.1111\/tbj.13003},\r\nissn = {1524-4741},\r\nyear = {2018},\r\ndate = {2018-07-01},\r\njournal = {Breast J},\r\nvolume = {24},\r\nnumber = {4},\r\npages = {509--518},\r\nabstract = {Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Close<\/a><\/p><\/div>Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69\u00a0years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1\u00a0years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in\u00a0situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2\u00a0cm (OR\u00a0=\u00a01.46; 95%CI\u00a0=\u00a01.03-2.08), metastatic positive (OR\u00a0=\u00a02.66; 95%CI\u00a0=\u00a01.21-5.86), and with a high Ki-67 proliferation rate (OR\u00a0=\u00a01.93; 95%CI\u00a0=\u00a01.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Close<\/a><\/p><\/div><\/i>doi:10.1111\/tbj.13003<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Close<\/a><\/p><\/div><\/div><\/div> Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for Research on International Agency Cancer Handbook Working Group. <\/p>
The IARC Perspective on Colorectal Cancer Screening<\/a>. Journal Article<\/span> <\/p>N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
N Engl J Med. <\/span>2018<\/span>;378<\/span>:1734\u20131740<\/span>.<\/p>Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
@article{pmid29580179,\r\ntitle = {The IARC Perspective on Colorectal Cancer Screening},\r\nauthor = {Lauby-Secretan B and Vilahur N and Bianchini F and Guha N and Straif K and International Agency for Research on Cancer Handbook Working Group},\r\ndoi = {10.1056\/NEJMsr1714643},\r\nissn = {1533-4406},\r\nyear = {2018},\r\ndate = {2018-05-01},\r\njournal = {N Engl J Med},\r\nvolume = {378},\r\nnumber = {18},\r\npages = {1734--1740},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Close<\/a><\/p><\/div><\/i>doi:10.1056\/NEJMsr1714643<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Close<\/a><\/p><\/div><\/div><\/div> Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Dierssen-Sotos T, G\u00f3mez-Acebo I, Palazuelos C, Fern\u00e1ndez-Navarro P, Altzibar JM, Gonz\u00e1lez-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tard\u00f3n A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Casta\u00f1o-Vinyals G, Ederra M, Vilorio-Marqu\u00e9s L, Amiano P, P\u00e9rez-G\u00f3mez B, Aragon\u00e9s N, Kogevinas M, Poll\u00e1n M, Llorca J. <\/p>
Validating a breast cancer score in Spanish women. The MCC-Spain study<\/a>. Journal Article<\/span> <\/p>Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Sci Rep. <\/span>2018<\/span>;8<\/span>:3036<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Abstract<\/a><\/span> | Links<\/a><\/span> | BibTeX<\/a><\/span> | Etiquetes: <\/span><\/p>@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
@article{pmid29445177,\r\ntitle = {Validating a breast cancer score in Spanish women. The MCC-Spain study},\r\nauthor = {Dierssen-Sotos T and G\u00f3mez-Acebo I and Palazuelos C and Fern\u00e1ndez-Navarro P and Altzibar JM and Gonz\u00e1lez-Donquiles C and Ardanaz E and Bustamante M and Alonso-Molero J and Vidal C and Bayo-Calero J and Tard\u00f3n A and Salas D and Marcos-Gragera R and Moreno V and Rodriguez-Cundin P and Casta\u00f1o-Vinyals G and Ederra M and Vilorio-Marqu\u00e9s L and Amiano P and P\u00e9rez-G\u00f3mez B and Aragon\u00e9s N and Kogevinas M and Poll\u00e1n M and Llorca J},\r\ndoi = {10.1038\/s41598-018-20832-0},\r\nissn = {2045-2322},\r\nyear = {2018},\r\ndate = {2018-02-01},\r\njournal = {Sci Rep},\r\nvolume = {8},\r\nnumber = {1},\r\npages = {3036},\r\nabstract = {A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.},\r\nkeywords = {},\r\npubstate = {published},\r\ntppubtype = {article}\r\n}\r\n<\/pre><\/div>Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Close<\/a><\/p><\/div>A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI\u2009=\u20090.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.<\/div>Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Close<\/a><\/p><\/div><\/i>doi:10.1038\/s41598-018-20832-0<\/a><\/li><\/ul><\/div>Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Close<\/a><\/p><\/div><\/div><\/div> Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Lope V, Garc\u00eda-P\u00e9rez J, P\u00e9rez-G\u00f3mez B, Pedraza-Flechas AM, Alguacil J, Gonz\u00e1lez-Galarzo MC, Alba MA, van der Haar R, Cort\u00e9s-Barrag\u00e1n RA, Pedraz-Pingarr\u00f3n C, Moreo P, Santamari\u00f1a C, Ederra M, Vidal C, Salas-Trejo D, S\u00e1nchez-Contador C, Llobet R, Poll\u00e1n M. <\/p>
Occupational exposures and mammographic density in Spanish women<\/a>. Journal Article<\/span> <\/p>Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Occup Environ Med. <\/span>2018<\/span>;75<\/span>:124\u2013131<\/span>.<\/p>Abstract<\/a><\/span> | Links<\/a><\/span> |
Abstract<\/a><\/span> | Links<\/a><\/span> |