La proporci\u00f3 de c\u00e0ncers d\u2019interval identificada mitjan\u00e7ant la prova de sang\noculta en femta en els programes poblacionals de cribratge de c\u00e0ncer colorectal\n\u00e9s, aproximadament, un 15%, i lleugerament inferior en rondes successives de\ncribratge. Segons les caracter\u00edstiques\ncl\u00edniques, \u00e9s m\u00e9s probable que apareguin c\u00e0ncers d\u2019interval en dones i que es\nlocalitzin al c\u00f2lon dret. A nivell molecular, els estudis han demostrat que els\nc\u00e0ncers d\u2019interval presenten, en major proporci\u00f3, inestabilitat de microsat\u00e8l\u00b7lits\ni nivells elevats de metilaci\u00f3 de l\u2019ADN comparant amb els c\u00e0ncers detectats en\nel proc\u00e9s de cribratge.<\/p>\n\n\n\n
Con\u00e8ixer les caracter\u00edstiques associades de c\u00e0ncers colorectals d\u2019interval en comparaci\u00f3 amb c\u00e0ncers detectats en el cribratge podria millorar la nostra comprensi\u00f3 de les vies carcinog\u00e8niques i es podria prevenir el c\u00e0ncer d\u2019interval mitjan\u00e7ant l\u2019estratificaci\u00f3 del risc, oferint estrat\u00e8gies de cribratge adaptades al risc individual de desenvolupar c\u00e0ncer colorectal.<\/p>\n\n\n\n Els tumors que no es detecten amb les proves de cribratge es coneixen com c\u00e0ncers d\u2019interval i es diagnostiquen despr\u00e9s d\u2019un resultat negatiu en l\u2019episodi de cribratge per\u00f2 abans de la seg\u00fcent invitaci\u00f3 del programa de detecci\u00f3 preco\u00e7 de c\u00e0ncer. L\u2019equip de la Unitat de Cribratge de C\u00e0ncer juntament amb investigadors de la Unitat de 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