@article{pmid28843166,

title = {Occupation and mammographic density: A population-based study (DDM-Occup)},

author = {García-Pérez J and Pollán M and Pérez-Gómez B and González-Sánchez M and Cortés Barragán RA and Maqueda Blasco J and González-Galarzo MC and Alba MÁ and van der Haar R and Casas S and Vicente C and Medina P and Ederra M and Santamariña C and Moreno MP and Casanova F and Pedraz-Pingarrón C and Moreo P and Ascunce N and García M and Salas-Trejo D and Sánchez-Contador C and Llobet R and Lope V},

doi = {10.1016/j.envres.2017.08.028},

issn = {1096-0953},

year  = {2017},

date = {2017-11-01},

journal = {Environ Res},

volume = {159},

pages = {355--361},

abstract = {INTRODUCTION: High mammographic density is one of the main risk factors for breast cancer. Although several occupations have been associated with breast cancer, there are no previous occupational studies exploring the association with mammographic density. Our objective was to identify occupations associated with high mammographic density in Spanish female workers.nnMETHODS: We conducted a population-based cross-sectional study of occupational determinants of high mammographic density in Spain, based on 1476 women, aged 45-68 years, recruited from seven screening centers within the Spanish Breast Cancer Screening Program network. Reproductive, family, personal, and occupational history data were collected. The latest occupation of each woman was collected and coded according to the 1994 National Classification of Occupations. Mammographic density was assessed from the cranio-caudal mammogram of the left breast using a semi-automated computer-assisted tool. Association between mammographic density and occupation was evaluated by using mixed linear regression models, using log-transformed percentage of mammographic density as dependent variable. Models were adjusted for age, body mass index, menopausal status, parity, smoking, alcohol intake, educational level, type of mammography, first-degree relative with breast cancer, and hormonal replacement therapy use. Screening center and professional reader were included as random effects terms.nnRESULTS: Mammographic density was higher, although non-statistically significant, among secondary school teachers (e = 1.41; 95%CI = 0.98-2.03) and nurses (e = 1.23; 95%CI = 0.96-1.59), whereas workers engaged in the care of people (e = 0.81; 95%CI = 0.66-1.00) and housewives (e = 0.87; 95%CI = 0.79-0.95) showed an inverse association with mammographic density. A positive trend for every 5 years working as secondary school teachers was also detected (p-value = 0.035).nnCONCLUSIONS: Nurses and secondary school teachers were the occupations with the highest mammographic density in our study, showing the latter a positive trend with duration of employment. Future studies are necessary to confirm if these results are due to chance or are the result of a true association whose causal hypothesis is, for the moment, unknown.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid28988175,

title = {Assessment of the effects of decision aids about breast cancer screening: a systematic review and meta-analysis},

author = {Martínez-Alonso M and Carles-Lavila M and Pérez-Lacasta MJ and Pons-Rodríguez A and Garcia M and Rué M and InforMa Group},

doi = {10.1136/bmjopen-2017-016894},

issn = {2044-6055},

year  = {2017},

date = {2017-10-01},

journal = {BMJ Open},

volume = {7},

number = {10},

pages = {e016894},

abstract = {OBJECTIVE: The aim of this systematic review and meta-analysis of randomised controlled trials (RCTs) and observational studies is to assess the effect of decision aids (DAs) in women aged 50 and below facing the decision to be screened for breast cancer.nnSETTING: Screening for breast cancer.nnINTERVENTION: DAs aimed to help women make a deliberative choice regarding participation in mammography screening by providing information on the options and outcomes.nnELIGIBLE STUDIES: We included published original, non-pilot, studies that assess the effect of DAs for breast cancer screening. We excluded the studies that evaluated only participation intention or actual uptake. The studies' risk of bias was assessed with the Cochrane Collaboration's tool for RCTs and the National Institutes of Health Quality Assessment Tool for non-RCTs.nnPRIMARY AND SECONDARY OUTCOMES: The main outcome measures were informed choice, decisional conflict and/or confidence, and knowledge. Secondary outcomes were values, attitudes, uncertainty and intention to be screened.nnRESULTS: A total of 607 studies were identified, but only 3 RCTs and 1 before-after study were selected. The use of DAs increased the proportion of women making an informed decision by 14%, 95% CI (2% to 27%) and the proportion of women with adequate knowledge by 12%, 95% CI (7% to 16%). We observed heterogeneity among the studies in confidence in the decision. The meta-analysis of the RCTs showed a significant decrease in confidence in the decision and in intention to be screened.nnCONCLUSIONS: Tools to aid decision making in screening for breast cancer improve knowledge and promote informed decision; however, we found divergent results on decisional conflict and confidence in the decision. Under the current paradigm change, which favours informed choice rather than maximising uptake, more research is necessary for the improvement of DAs.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid28899412,

title = {The effect of information about the benefits and harms of mammography on women's decision-making: study protocol for a randomized controlled trial},

author = {Carles M and Martínez-Alonso M and Pons A and Pérez-Lacasta MJ and Perestelo-Pérez L and Sala M and Vidal C and Garcia M and Toledo-Chávarri A and Codern N and Feijoo-Cid M and Romero A and Pla R and Soler-González J and Castells X and Rué M and InforMa Group},

doi = {10.1186/s13063-017-2161-7},

issn = {1745-6215},

year  = {2017},

date = {2017-09-01},

journal = {Trials},

volume = {18},

number = {1},

pages = {426},

abstract = {BACKGROUND: The decision to participate or not in breast cancer screening is complex due to the trade-off between the expected benefit of breast cancer mortality reduction and the major harm of overdiagnosis. It seems ethically necessary to inform women so that they can actively participate in decision-making and make an informed choice based on their values and preferences. The objective of this study is to assess the effects of receiving information about the benefits and harms of screening on decision-making, in women approaching the age of invitation to mammography screening.nnMETHODS: A two-stage, randomized controlled trial (RCT). In the first stage, 40 Basic Health Areas (BHAs) will be selected and randomized to intervention or control. In the second stage, women within each BHA will be randomly selected (n = 400). Four breast cancer screening programs (BCSPs) of the Spanish public health system, three in Catalonia and one in the Canary Islands will participate in the study. Women in the intervention arm will receive a leaflet with detailed information on the benefits and harms of screening using mammography. Women in the control arm will receive a standard leaflet that does not mention harms and recommends accepting the invitation to participate in the biennial examinations of the BCSP. The primary outcome is informed choice, a dichotomous variable that combines knowledge, attitudes, and intentions. Secondary outcomes include decisional conflict; confidence in the decision made; anxiety about screening participation; worry about breast cancer; anticipated regret; time perspective; perceived importance of benefits/harms of screening; perceived risk of breast cancer; and leaflet acceptability. Primary and secondary outcomes are assessed 2-3 weeks after the intervention.nnDISCUSSION: This is the first RCT that assesses the effect of informing about the benefits and harms of breast cancer screening in Spain in women facing the decision to be screened using mammography. It aims to assess the impact of information on several decisional outcomes and to contribute to paving the road towards shared decision-making in breast cancer screening in our country.nnTRIAL REGISTRATION: ClinicalTrials.gov registry, ID: NCT03046004 . Retrospectively registered on 4 February 2017. Trial name: InforMa study.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid28880236,

title = {Sedentary and Physical Activity Patterns in Adults with Intellectual Disability},

author = {Oviedo GR and Travier N and Guerra-Balic M},

doi = {10.3390/ijerph14091027},

issn = {1660-4601},

year  = {2017},

date = {2017-09-01},

journal = {Int J Environ Res Public Health},

volume = {14},

number = {9},

abstract = {Little is known about the patterns of sedentary time (ST) and physical activity (PA) levels throughout the week among adults and older adults with Intellectual Disability (ID). We analyzed ST and PA patterns of adults and older adults with ID. Forty-two adults and 42 older adults with mild to severe ID participated in this study. Height and weight were obtained to calculate Body Mass Index (BMI). Body fat and fat-free mass percentages were also obtained. Patterns of PA levels and ST were assessed with GT3X Actigraph accelerometers. Adults performed higher amounts of total PA and moderate to vigorous PA than older adults during the week, on weekdays and in center time (all  > 0.05). No differences between males and females were found for either PA levels or ST. Only 10.7% of the participants met the global recommendations on PA for health. The participants of the current study showed low PA levels and a high prevalence of ST. Interestingly, when comparing age and/or sex groups, no differences were observed for ST. Our findings provide novel and valuable information to be considered in future interventions aiming to increase PA levels and reduce ST.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid27433880,

title = {False-negative rate cannot be reduced by lowering the haemoglobin concentration cut-off in colorectal cancer screening using faecal immunochemical test},

author = {Ibañez-Sanz G and Garcia M and Milà N and Rodríguez-Moranta F and Binefa G and Gómez-Matas J and Benito L and Padrol I and Barenys M and Moreno V},

doi = {10.1097/CEJ.0000000000000281},

issn = {1473-5709},

year  = {2017},

date = {2017-09-01},

journal = {Eur J Cancer Prev},

volume = {26},

number = {5},

pages = {365--367},

abstract = {The aim of this study was to analyse false-negative (FN) results of the faecal immunochemical test (FIT) and its determinants in a colorectal cancer screening programme in Catalonia. We carried out a cross-sectional study among 218 screenees with a negative FIT result who agreed to undergo a colonoscopy. A false-negative result was defined as the detection, at colonoscopy, of intermediate/high-risk polyps or colorectal cancer in a patient with a previous negative FIT (<20 µgHb/g). Multivariate logistic regression models were constructed to identify sociodemographic (sex, age) and screening variables (quantitative faecal haemoglobin, colonoscopy findings) related to FN results. Adjusted odds ratios and their 95% confidence intervals were estimated. There were 15.6% FN FIT results. Faecal haemoglobin was undetected in 45.5% of these results and was below 4 µgHb/g in 94.0% of the individuals with a FN result. About 60% of the lesions were located in the proximal colon, whereas the expected percentage was 30%. Decreasing the positivity threshold of FIT does not increase the detection rate of advanced neoplasia, but may increase the costs and potential adverse effects.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid28456099,

title = {Thyroid disorders and mammographic density in Spanish women: Var-DDM study},

author = {Pedraza-Flechas AM and Lope V and Vidal C and Sánchez-Contador C and Santamariña C and Pedraz-Pingarrón C and Moreo P and Ascunce N and Miranda-García J and Llobet R and Aragonés N and Salas-Trejo D and Pollán M and Pérez-Gómez B and DDM/Var-DDM-Spain},

doi = {10.1016/j.breast.2017.04.011},

issn = {1532-3080},

year  = {2017},

date = {2017-08-01},

journal = {Breast},

volume = {34},

pages = {12--17},

abstract = {OBJECTIVES: The association between breast cancer (BC) and thyroid disorders has been widely explored with unclear results. Mammographic density (MD) is one of the strongest risk factor for BC. This study explores the relationship between thyroid diseases and MD in Spanish women.nnMATERIALS & METHODS: This cross-sectional study covered 2883 women aged 47-71 years participating in 7 BC screening programs in 2010. They allowed access to their mammograms, had anthropometrical-measures taken, and answered a telephonic epidemiological interview which included specific questions on thyroid diseases. Percentage of MD was assessed with a semiautomatic-computer tool (DM-scan) by two trained radiologists. We calculated the geometric mean of MD percentages (mean MD). Multivariable mixed linear regression models with random screening-center-specific intercepts were fitted, using log-transformed percentage of MD as dependent variable and adjusting for age, body mass index, menopausal status and other confounders. e represents the relative increase of mean MD.nnRESULTS: 13.9% of the participants reported personal history of thyroid disease. MD was not associated to hyperthyroidism (e:1.05, 95%CI: 0.82-1.36), hypothyroidism (e:1.02, 95%CI: 0.75-1.38), thyroid nodules (e:1.01, 95%CI: 0.85-1.19) or thyroid cancer (e:1.03, 95%CI: 0.56-1.92). However, women with goiter had lower MD (mean MD: 13.4% vs mean MD: 10.6%; e:0.79, 95%CI: 0.64-0.98) and those with Hashimoto thyroiditis had higher MD (mean MD: 13.3% vs mean MD: 25.8%; e:1.94, 95%CI: 1.00-3.77).nnCONCLUSION: Functional thyroid disorders were not related to MD. However, MD was lower in women with goiter and higher in those reporting Hashimoto's thyroiditis. These relationships should be confirmed in future studies.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid28319346,

title = {Determination of oleanolic acid in human plasma and its association with olive oil intake in healthy Spanish adults within the EPIC Spain cohort study},

author = {Buckland G and Pastor A and Lujan-Barroso L and Gonzalez CA and Travier N and Amiano P and Huerta JM and Agudo A and Navarro C and Chirlaque MD and Sánchez MJ and Rodríguez-Barranco M and Barricarte A and Ardanaz E and Dorronsoro M and Molinuevo A and Quirós JR and de la Torre R},

doi = {10.1002/mnfr.201600927},

issn = {1613-4133},

year  = {2017},

date = {2017-08-01},

journal = {Mol Nutr Food Res},

volume = {61},

number = {8},

abstract = {SCOPE: Oleanolic acid (OA) is an important triterpenic compound found in olive oil, however little is known about its concentrations in human plasma. We aimed to determine plasma OA levels in a healthy Spanish population and compare them with estimates of dietary olive oil intake.nnMETHODS AND RESULTS: The final study sample included 141 individuals randomly selected from the European Prospective Investigation into Cancer and Nutrition Spanish cohort. Dietary olive oil intake was estimated using validated dietary history questionnaires. OA concentrations were determined in plasma (from the participants' stored blood samples) using a HPLC-MS method. Correlation coefficients between OA and olive oil intake were calculated, adjusting for center; sex; age; consumption of olives, apples, grapes, and red wine; and fasting state. The mean OA concentration in olive oil nonconsumers was 0.72 ng/mL (SD 0.82), while in the high olive oil intake group it was 1.32 ng/mL (SD 1.14). The fully adjusted partial Spearman correlations coefficients reached 0.36 (p-value < 0.001) overall, varying minimally by sex and fasting state.nnCONCLUSION: This is the first study providing steady-state concentrations of triterpenes in humans. The results show that there was low-to-moderate correlation between OA concentrations and olive oil intake in this population.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid28380695,

title = {Adherence to nutrition-based cancer prevention guidelines and breast, prostate and colorectal cancer risk in the MCC-Spain case-control study},

author = {Romaguera D and Gracia-Lavedan E and Molinuevo A and de Batlle J and Mendez M and Moreno V and Vidal C and Castelló A and Pérez-Gómez B and Martín V and Molina AJ and Dávila-Batista V and Dierssen-Sotos T and Gómez-Acebo I and Llorca J and Guevara M and Castilla J and Urtiaga C and Llorens-Ivorra C and Fernández-Tardón G and Tardón A and Lorca JA and Marcos-Gragera R and Huerta JM and Olmedo-Requena R and Jimenez-Moleon JJ and Altzibar J and de Sanjosé S and Pollán M and Aragonés N and Castaño-Vinyals G and Kogevinas M and Amiano P},

doi = {10.1002/ijc.30722},

issn = {1097-0215},

year  = {2017},

date = {2017-07-01},

journal = {Int J Cancer},

volume = {141},

number = {1},

pages = {83--93},

abstract = {Prostate, breast and colorectal cancer are the most common tumours in Spain. The aim of the present study was to evaluate the association between adherence to nutrition-based guidelines for cancer prevention and prostate, breast and colorectal cancer, in the MCC-Spain case-control study. A total of 1,718 colorectal, 1,343 breast and 864 prostate cancer cases and 3,431 population-based controls recruited between 2007 and 2012, were included in the present study. The World Cancer Research Fund/American Institute for Cancer Research (WCRC/AICR) score based on six recommendations for cancer prevention (on body fatness, physical activity, foods and drinks that promote weight gain, plant foods, animal foods and alcoholic drinks; score range 0-6) was constructed. We used unconditional logistic regression analysis adjusting for potential confounders. One-point increment in the WCRF/AICR score was associated with 25% (95% CI 19-30%) lower risk of colorectal, and 15% (95% CI 7-22%) lower risk of breast cancer; no association with prostate cancer was detected, except for cases with a Gleason score ≥7 (poorly differentiated/undifferentiated tumours) (OR 0.87, 95% CI 0.76-0.99). These results add to the wealth of evidence indicating that a great proportion of common cancer cases could be avoided by adopting healthy lifestyle habits.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid28470951,

title = {Biomarkers expression in benign breast diseases and risk of subsequent breast cancer: a case-control study},

author = {Posso M and Corominas JM and Serrano L and Román M and Torá-Rocamora I and Domingo L and Romero A and Quintana MJ and Vernet-Tomas M and Baré M and Vidal C and Sánchez M and Saladié F and Natal C and Ferrer J and Servitja S and Sala M and Castells X and BELE Study Group},

doi = {10.1002/cam4.1080},

issn = {2045-7634},

year  = {2017},

date = {2017-06-01},

journal = {Cancer Med},

volume = {6},

number = {6},

pages = {1482--1489},

abstract = {Women with benign breast diseases (BBD) have a high risk of breast cancer. However, no biomarkers have been clearly established to predict cancer in these women. Our aim was to explore whether estrogen receptor (ER), progesterone receptor (PR), and Ki67 expression stratify risk of breast cancer in screened women with BBD. We conducted a nested case-control study. Women with breast cancer and prior BBDs (86 cases) were matched to women with prior BBDs who were free from breast cancer (172 controls). The matching factors were age at BBD diagnosis, type of BBD, and follow-up time since BBD diagnosis. ER, PR, and Ki67 expression were obtained from BBDs' specimens. Conditional logistic regression was used to estimate odds ratios (ORs), and 95% confidence intervals (CIs) of breast cancer risk according to ER, PR, and Ki67 expression. Women with >90% of ER expression had a higher risk of breast cancer (OR = 2.63; 95% CI: 1.26-5.51) than women with ≤70% of ER expression. Similarly, women with >80% of PR expression had a higher risk of breast cancer (OR = 2.22; 95% CI: 1.15-4.27) than women with ≤40% of PR expression. Women with proliferative disease and ≥1% of Ki67 expression had a nonsignificantly increased risk of breast cancer (OR = 1.16; 95% CI: 0.46-2.90) than women with <1% of Ki67 expression. A high expression of ER and PR in BBD is associated with an increased risk of subsequent breast cancer. In proliferative disease, high Ki67 expression may also have an increased risk. This information is helpful to better characterize BBD and is one more step toward personalizing the clinical management of these women.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid28336582,

title = {High Mammographic Density in Long-Term Night-Shift Workers: DDM-Spain/Var-DDM},

author = {Pedraza-Flechas AM and Lope V and Sánchez-Contador C and Santamariña C and Pedraz-Pingarrón C and Moreo P and Ederra M and Miranda-García J and Vidal C and Llobet R and Aragonés N and Salas-Trejo D and Pollán M and Pérez-Gómez B and DDM-Spain/Var-DDM},

doi = {10.1158/1055-9965.EPI-16-0507},

issn = {1538-7755},

year  = {2017},

date = {2017-06-01},

journal = {Cancer Epidemiol Biomarkers Prev},

volume = {26},

number = {6},

pages = {905--913},

abstract = { Night-shift work (NSW) has been suggested as a possible cause of breast cancer, and its association with mammographic density (MD), one of the strongest risk factors for breast cancer, has been scarcely addressed. This study examined NSW and MD in Spanish women. The study covered 2,752 women aged 45-68 years recruited in 2007-2008 in 7 population-based public breast cancer screening centers, which included 243 women who had performed NSW for at least one year. Occupational data and information on potential confounders were collected by personal interview. Two trained radiologist estimated the percentage of MD assisted by a validated semiautomatic computer tool (DM-scan). Multivariable mixed linear regression models with random screening center-specific intercepts were fitted using log-transformed percentage of MD as the dependent variable and adjusting by known confounding variables. Having ever worked in NSW was not associated with MD [Formula: see text]:0.96; 95% confidence interval (CI), 0.86-1.06]. However, the adjusted geometric mean of the percentage of MD in women with NSW for more than 15 years was 25% higher than that of those without NSW history (MD:20.7% vs. MD:16.5%;[Formula: see text]:1.25; 95% CI,1.01-1.54). This association was mainly observed in postmenopausal participants ([Formula: see text]:1.28; 95% CI, 1.00-1.64). Among NSW-exposed women, those with ≤2 night-shifts per week had higher MD than those with 5 to 7 nightshifts per week ([Formula: see text]:1.42; 95% CI, 1.10-1.84). Performing NSW was associated with higher MD only in women with more than 15 years of cumulated exposure. These findings warrant replication in futures studies. Our findings suggest that MD could play a role in the pathway between long-term NSW and breast cancer. .},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid28427083,

title = {Cumulative risk of breast cancer screening outcomes according to the presence of previous benign breast disease and family history of breast cancer: supporting personalised screening},

author = {Román M and Quintana MJ and Ferrer J and Sala M and Castells X},

doi = {10.1038/bjc.2017.107},

issn = {1532-1827},

year  = {2017},

date = {2017-05-01},

journal = {Br J Cancer},

volume = {116},

number = {11},

pages = {1480--1485},

abstract = {BACKGROUND: Our aim was to assess the cumulative risk of false-positive screening results, screen-detected cancer, and interval breast cancer in mammography screening among women with and without a previous benign breast disease and a family history of breast cancer.nnMETHODS: The cohort included 42 928 women first screened at the age of 50-51 years at three areas of the Spanish Screening Programme (Girona, and two areas in Barcelona) between 1996 and 2011, and followed up until December 2012. We used discrete-time survival models to estimate the cumulative risk of each screening outcome over 10 biennial screening exams.nnRESULTS: The cumulative risk of false-positive results, screen-detected breast cancer, and interval cancer was 36.6, 5.3, and 1.4 for women with a previous benign breast disease, 24.1, 6.8, and 1.6% for women with a family history of breast cancer, 37.9, 9.0, and 3.2%; for women with both a previous benign breast disease and a family history, and 23.1, 3.2, and 0.9% for women without either of these antecedents, respectively.nnCONCLUSIONS: Women with a benign breast disease or a family history of breast cancer had an increased cumulative risk of favourable and unfavourable screening outcomes than women without these characteristics. A family history of breast cancer did not increase the cumulative risk of false-positive results. Identifying different risk profiles among screening participants provides useful information to stratify women according to their individualised risk when personalised screening strategies are discussed.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid28364862,

title = {Sleep patterns, sleep disorders and mammographic density in spanish women: The DDM-Spain/Var-DDM study},

author = {Pedraza-Flechas AM and Lope V and Moreo P and Ascunce N and Miranda-García J and Vidal C and Sánchez-Contador C and Santamariña C and Pedraz-Pingarrón C and Llobet R and Aragonés N and Salas-Trejo D and Pollán M and Pérez-Gómez B and DDM/Var-DDM-Spain},

doi = {10.1016/j.maturitas.2017.02.015},

issn = {1873-4111},

year  = {2017},

date = {2017-05-01},

journal = {Maturitas},

volume = {99},

pages = {105--108},

abstract = {We explored the relationship between sleep patterns and sleep disorders and mammographic density (MD), a marker of breast cancer risk. Participants in the DDM-Spain/var-DDM study, which included 2878 middle-aged Spanish women, were interviewed via telephone and asked questions on sleep characteristics. Two radiologists assessed MD in their left craneo-caudal mammogram, assisted by a validated semiautomatic-computer tool (DM-scan). We used log-transformed percentage MD as the dependent variable and fitted mixed linear regression models, including known confounding variables. Our results showed that neither sleeping patterns nor sleep disorders were associated with MD. However, women with frequent changes in their bedtime due to anxiety or depression had higher MD (e:1.53;95%CI:1.04-2.26).},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid28145105,

title = {A qualitative study on a decision aid for breast cancer screening: Views from women and health professionals},

author = {Toledo-Chávarri A and Rué M and Codern-Bové N and Carles-Lavila M and Perestelo-Pérez L and Pérez-Lacasta MJ and Feijoo-Cid M and InforMa Study Group},

doi = {10.1111/ecc.12660},

issn = {1365-2354},

year  = {2017},

date = {2017-05-01},

journal = {Eur J Cancer Care (Engl)},

volume = {26},

number = {3},

abstract = {This qualitative study evaluates a decision aid that includes the benefits and harms of breast cancer screening and analyses women's perception of the information received and healthcare professionals' perceptions of the convenience of providing it. Seven focus groups of women aged 40-69 years (n = 39) and two groups of healthcare professionals (n = 23) were conducted in Catalonia and the Canary Islands. The focus groups consisted of guided discussions regarding decision-making about breast cancer screening, and acceptability and feasibility of the decision aid. A content analysis was performed. Women positively value receiving information regarding the benefits and harms of breast cancer screening. Several women had difficulties understanding some concepts, especially those regarding overdiagnosis. Women preferred to share the decisions on screening with healthcare professionals. The professionals noted the lack of inclusion of some harms and benefits in the decision aid, and proposed improving the clarity of the statistical information. The information on overdiagnosis generates confusion among women and controversy among professionals. Faced with the new information presented by the decision aid, the majority of women prefer shared decision-making; however, its feasibility might be limited by a lack of knowledge and attitudes of rejection from healthcare professionals.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid26411994,

title = {Identifying Nursing Interventions in a Cancer Screening Program Using Nursing Interventions Classification Taxonomy},

author = {Benito L and Lluch MT and Falcó AM and García M and Puig M},

doi = {10.1111/2047-3095.12115},

issn = {2047-3095},

year  = {2017},

date = {2017-04-01},

journal = {Int J Nurs Knowl},

volume = {28},

number = {2},

pages = {70--75},

abstract = {PURPOSE: This study aimed to investigate which Nursing Interventions Classification (NIC) labels correspond to specific nursing interventions provided during cancer screening to establish a nursing documentation system.nnMETHOD: This descriptive study was conducted to identify and classify the interventions that cancer screening nurses perform based on an initial list.nnFINDINGS: The initial list was grouped into 15 interventions that corresponded to four domains and eight classes.nnCONCLUSION: The study found expert consensus regarding the duties of cancer screening nurses and identified 15 interventions that should be implemented in clinical practice for cancer screening care, according to the NIC taxonomy.nnIMPLICATIONS: This study is the first step in developing indicators to assess nursing performance in cancer screening, and it helps to establish the core competency requirements for cancer screening nurses.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid28233817,

title = {Risk Model for Colorectal Cancer in Spanish Population Using Environmental and Genetic Factors: Results from the MCC-Spain study},

author = {Ibáñez-Sanz G and Díez-Villanueva A and Alonso MH and Rodríguez-Moranta F and Pérez-Gómez B and Bustamante M and Martin V and Llorca J and Amiano P and Ardanaz E and Tardón A and Jiménez-Moleón JJ and Peiró R and Alguacil J and Navarro C and Guinó E and Binefa G and Fernández-Navarro P and Espinosa A and Dávila-Batista V and Molina AJ and Palazuelos C and Castaño-Vinyals G and Aragonés N and Kogevinas M and Pollán M and Moreno V},

doi = {10.1038/srep43263},

issn = {2045-2322},

year  = {2017},

date = {2017-02-01},

journal = {Sci Rep},

volume = {7},

pages = {43263},

abstract = {Colorectal cancer (CRC) screening of the average risk population is only indicated according to age. We aim to elaborate a model to stratify the risk of CRC by incorporating environmental data and single nucleotide polymorphisms (SNP). The MCC-Spain case-control study included 1336 CRC cases and 2744 controls. Subjects were interviewed on lifestyle factors, family and medical history. Twenty-one CRC susceptibility SNPs were genotyped. The environmental risk model, which included alcohol consumption, obesity, physical activity, red meat and vegetable consumption, and nonsteroidal anti-inflammatory drug use, contributed to CRC with an average per factor OR of 1.36 (95% CI 1.27 to 1.45). Family history of CRC contributed an OR of 2.25 (95% CI 1.87 to 2.72), and each additional SNP contributed an OR of 1.07 (95% CI 1.04 to 1.10). The risk of subjects with more than 25 risk alleles (5 quintile) was 82% higher (OR 1.82, 95% CI 1.11 to 2.98) than subjects with less than 19 alleles (1 quintile). This risk model, with an AUROC curve of 0.63 (95% CI 0.60 to 0.66), could be useful to stratify individuals. Environmental factors had more weight than the genetic score, which should be considered to encourage patients to achieve a healthier lifestyle.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid28257491,

title = {The association between adult attained height and sitting height with mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC)},

author = {Sawada N and Wark PA and Merritt MA and Tsugane S and Ward HA and Rinaldi S and Weiderpass E and Dartois L and His M and Boutron-Ruault MC and Turzanski-Fortner R and Kaaks R and Overvad K and Redondo ML and Travier N and Molina-Portillo E and Dorronsoro M and Cirera L and Ardanaz E and Perez-Cornago A and Trichopoulou A and Lagiou P and Valanou E and Masala G and Pala V and Hm Peeters P and T van der Schouw Y and Melander O and Manjer J and da Silva M and Skeie G and Tjønneland A and Olsen A and J Gunter M and Riboli E and J Cross A},

doi = {10.1371/journal.pone.0173117},

issn = {1932-6203},

year  = {2017},

date = {2017-01-01},

journal = {PLoS One},

volume = {12},

number = {3},

pages = {e0173117},

abstract = {Adult height and sitting height may reflect genetic and environmental factors, including early life nutrition, physical and social environments. Previous studies have reported divergent associations for height and chronic disease mortality, with positive associations observed for cancer mortality but inverse associations for circulatory disease mortality. Sitting height might be more strongly associated with insulin resistance; however, data on sitting height and mortality is sparse. Using the European Prospective Investigation into Cancer and Nutrition study, a prospective cohort of 409,748 individuals, we examined adult height and sitting height in relation to all-cause and cause-specific mortality. Height was measured in the majority of participants; sitting height was measured in ~253,000 participants. During an average of 12.5 years of follow-up, 29,810 deaths (11,931 from cancer and 7,346 from circulatory disease) were identified. Hazard ratios (HR) with 95% confidence intervals (CI) for death were calculated using multivariable Cox regression within quintiles of height. Height was positively associated with cancer mortality (men: HRQ5 vs. Q1 = 1.11, 95%CI = 1.00-1.24; women: HRQ5 vs. Q1 = 1.17, 95%CI = 1.07-1.28). In contrast, height was inversely associated with circulatory disease mortality (men: HRQ5 vs. Q1 = 0.63, 95%CI = 0.56-0.71; women: HRQ5 vs. Q1 = 0.81, 95%CI = 0.70-0.93). Although sitting height was not associated with cancer mortality, it was inversely associated with circulatory disease (men: HRQ5 vs. Q1 = 0.64, 95%CI = 0.55-0.75; women: HRQ5 vs. Q1 = 0.60, 95%CI = 0.49-0.74) and respiratory disease mortality (men: HRQ5 vs. Q1 = 0.45, 95%CI = 0.28-0.71; women: HRQ5 vs. Q1 = 0.60, 95%CI = 0.40-0.89). We observed opposing effects of height on cancer and circulatory disease mortality. Sitting height was inversely associated with circulatory disease and respiratory disease mortality.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}