@article{pmid36543351,

title = {Everything causes cancer? Beliefs and attitudes towards cancer prevention among anti-vaxxers, flat earthers, and reptilian conspiracists: online cross sectional survey},

author = {Paytubi S and Benavente Y and Montoliu A and Binefa G and Brotons M and Ibáñez R and Ochoa C and Peremiquel-Trillas P and Serrano B and Travier N and Alemany L and Costas L},

doi = {10.1136/bmj-2022-072561},

issn = {1756-1833},

year  = {2022},

date = {2022-12-01},

journal = {BMJ},

volume = {379},

pages = {e072561},

abstract = {OBJECTIVE: To evaluate, using an online non-probability sample, the beliefs about and attitudes towards cancer prevention of people professing vaccination scepticism or conspiracy theories.nnDESIGN: Cross sectional survey.nnSETTING: Data collected mainly from ForoCoches (a well known Spanish forum) and other platforms, including Reddit (English), 4Chan (English), HispaChan (Spanish), and a Spanish language website for cancer prevention (mejorsincancer.org) from January to March 2022.nnPARTICIPANTS: Among 1494 responders, 209 were unvaccinated against covid-19, 112 preferred alternative rather than conventional medicine, and 62 reported flat earth or reptilian beliefs.nnMAIN OUTCOME MEASURES: Cancer beliefs assessed using the Cancer Awareness Measure (CAM) and Cancer Awareness Measure Mythical Causes Scale (CAM-MYCS) (both validated tools).nnRESULTS: Awareness of the actual causes of cancer was greater (median CAM score 63.6%) than that of mythical causes (41.7%). The most endorsed mythical causes of cancer were eating food containing additives or sweeteners, feeling stressed, and eating genetically modified food. Awareness of the actual and mythical causes of cancer among the unvaccinated, alternative medicine, and conspiracy groups was lower than among their counterparts. A median of 54.5% of the actual causes was accurately identified among each of the unvaccinated, alternative medicine, and conspiracy groups, and a median of 63.6% was identified in each of the three corresponding counterparts (P=0.13, 0.04, and 0.003, respectively). For mythical causes, medians of 25.0%, 16.7%, and 16.7% were accurately identified in the unvaccinated, alternative medicine, and conspiracy groups, respectively; a median of 41.7% was identified in each of the three corresponding counterparts (P<0.001 in adjusted models for all comparisons). In total, 673 (45.0%) participants agreed with the statement "It seems like everything causes cancer." No significant differences were observed among the unvaccinated (44.0%), conspiracist (41.9%), or alternative medicine groups (35.7%), compared with their counterparts (45.2%, 45.7%, and 45.8%, respectively).nnCONCLUSIONS: Almost half of the participants agreed that "It seems like everything causes cancer," which highlights the difficulty that society encounters in differentiating actual and mythical causes owing to mass information. People who believed in conspiracies, rejected the covid-19 vaccine, or preferred alternative medicine were more likely to endorse the mythical causes of cancer than their counterparts but were less likely to endorse the actual causes of cancer. These results suggest a direct connection between digital misinformation and consequent erroneous health decisions, which may represent a further preventable fraction of cancer.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid35963311,

title = {Guidance for setting international standards on reporting longitudinal adherence to stool-based colorectal cancer screening},

author = {van Wifferen F and Greuter MJE and Lissenberg-Witte BI and Carvalho B and Meijer GA and Dekker E and Campari C and Garcia M and Rabeneck L and Lansdorp-Vogelaar I and Senore C and Coupé VMH and ICSN Colorectal Cancer Screening Working Group},

doi = {10.1016/j.ypmed.2022.107187},

issn = {1096-0260},

year  = {2022},

date = {2022-11-01},

journal = {Prev Med},

volume = {164},

pages = {107187},

abstract = {Longitudinal adherence to colorectal cancer (CRC) screening is reported using different summarizing measures, which hampers international comparison. We provide evidence to guide recommendations on which longitudinal adherence measure to report. Using adherence data over four stool-based CRC screening rounds in three countries, we calculated six summarizing adherence measures; adherence over all rounds, adherence per round, rescreening, full programme adherence (yes/no), regularity (never/inconsistent/consistent screenees) and number of times participated. For each measure, we calculated the accuracy in capturing the observed adherence patterns. Using the ASCCA model, we predicted screening effectiveness when using summarizing measures as model input versus the observed adherence patterns. Adherence over all rounds in the Italian, Spanish and Dutch cohorts was 64.9%, 42.8% and 61.5%, respectively, and the proportion of consistent screenees was 50.9%, 26.3% and 45.7%. Number of times participated and regularity were most accurate and resulted in similar model-predicted screening effectiveness as simulating the observed adherence patterns of Italy, Spain and the Netherlands (mortality reductions: 24.4%, 16.9% and 23.5%). Adherence over all rounds and adherence per round were least accurate. Screening effectiveness was overestimated when using adherence over all rounds (mortality reductions: 26.8%, 19.4% and 25.7%) and adherence per round (mortality reductions: 26.8%, 19.5% and 25.9%). To conclude, number of times participated and regularity were most accurate and resulted in similar model-predicted screening effectiveness as using the observed adherence patterns. However they require longitudinal data. To facilitate international comparison of CRC screening programme performance, consensus on an accurate adherence measure to report should be reached.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid36351714,

title = {Women's preference to apply shared decision-making in breast cancer screening: a discrete choice experiment},

author = {Hernández-Leal MJ and Pérez-Lacasta MJ and Cardona-Cardona A and Codern-Bové N and Vidal-Lancis C and Rue M and Forné C and Carles-Lavila M and Pro-Share Group},

doi = {10.1136/bmjopen-2022-064488},

issn = {2044-6055},

year  = {2022},

date = {2022-11-01},

journal = {BMJ Open},

volume = {12},

number = {11},

pages = {e064488},

abstract = {OBJECTIVE: To analyse women's stated preferences for establishing the relative importance of each attribute of shared decision-making (SDM) and their willingness to pay (WTP) for more participatory care in breast cancer screening programmes (BCSP).nnDESIGN: A discrete choice experiment was designed with 12 questions (choice tasks). It included three attributes: 'How the information is obtained', regarding benefits and harms; whether there is a 'Dialogue for scheduled mammography' between the healthcare professional and the woman; and, 'Who makes the decision', regarding participation in BCSP. Data were obtained using a survey that included 12 choice tasks, 1 question on WTP and 7 socioeconomic-related questions. The analysis was performed using conditional mixed-effect logit regression and stratification according to WTP.nnSETTING: Data collection related to BCSP was conducted between June and November 2021 in Catalonia, Spain.nnPARTICIPANTS: Sixty-five women aged between 50 and 60.nnMAIN OUTCOME MEASURES: Women's perceived utility of each attribute, trade-off on these attributes and WTP for SDM in BCSP.nnRESULT: The only significant attribute was 'Who makes the decision'. The decision made alone (coefficient=2.879; 95% CI=2.297 to 3.461) and the decision made together with a healthcare professional (2.375; 95% CI=1.573 to 3.177) were the options preferred by women. The former contributes 21% more utility than the latter. Moreover, 52.3% of the women stated a WTP of €10 or more for SDM. Women's preferences regarding attributes did not influence their WTP.nnCONCLUSIONS: The participant women refused a current paternalistic model and preferred either SDM or informed decision-making in BCSP.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid36113447,

title = {High HIV/STI prevalence among cisgender men and transgender women sex workers attending community-based centres in Barcelona, Spain: The Sweetie Project},

author = {Ferrer L and González V and Martró E and Folch C and Saludes V and Muñoz R and Rodríguez V and Morales A and Meroño M and Morey F and Sanjosé S and Casabona J},

doi = {10.1177/09564624221116536},

issn = {1758-1052},

year  = {2022},

date = {2022-10-01},

journal = {Int J STD AIDS},

volume = {33},

number = {12},

pages = {1045--1053},

abstract = {BACKGROUND: The aim of this study was to describe the socio-demographics, and the sexual and health-seeking behaviours of cisgender men and transgender women sex workers (M & TWSW) attending community-based organisations (CBOs) in Barcelona, Spain, as well as to estimate the prevalence of HIV, hepatitis B virus (HBV), hepatitis C virus (HCV),  (CT) and  (NG) among them at different anatomical sites.nnMETHODS: The Sweetie Project was a community-based cross-sectional study of 147 M & TWSW recruited in two CBOs in Barcelona between 2017 and 2018. A nurse collected biological samples from rectum, pharynx and urethra from the subjects at each CBO and the participants self-completed an epidemiological questionnaire.nnRESULTS: The highest prevalence observed was for HIV infection (25.3%) followed by bacterial STIs (NG 19.2% and CT 10.3%). The most prevalent anatomical site was pharyngeal (17.7%) followed by rectal (13.8%). More than half of participants who had a pharyngeal infection presented an isolated pharyngeal infection (57.7%) and half of those who had a rectal or urethral infection presented an isolated infection respectively. The seroprevalence of HCV and HBV was 2.4% and 34.2% respectively. There was a poor but statistically significant correlation between HIV and rectal CT infection ( = 0.31), previous exposure to HCV ( = 0.27) or self-reported STI ( = 0.23), as well as between previous exposure to HCV and rectal CT ( = 0.21) or self-reported STI ( = 0.20).nnDISCUSSION: The Sweetie Project confirms the high burden of HIV and bacterial STIs among a sample of M&TWSW recruited in CBOs and reinforces the need to routinely screen them at all exposed anatomical sites.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid35100894,

title = {Prioritisation of colonoscopy services in colorectal cancer screening programmes to minimise impact of COVID-19 pandemic on predicted cancer burden: A comparative modelling study},

author = {van Wifferen F and de Jonge L and Worthington J and Greuter MJE and Lew JB and Nadeau C and van den Puttelaar R and Feletto E and Yong JHE and Lansdorp-Vogelaar I and Canfell K and Coupé VMH and COVID-19 and Cancer Global Modelling Consortium (CCGMC) working group 2},

doi = {10.1177/09691413211056777},

issn = {1475-5793},

year  = {2022},

date = {2022-06-01},

journal = {J Med Screen},

volume = {29},

number = {2},

pages = {72--83},

abstract = {OBJECTIVES: Colorectal cancer (CRC) screening with a faecal immunochemical test (FIT) has been disrupted in many countries during the COVID-19 pandemic. Performing catch-up of missed screens while maintaining regular screening services requires additional colonoscopy capacity that may not be available. This study aimed to compare strategies that clear the screening backlog using limited colonoscopy resources.nnMETHODS: A range of strategies were simulated using four country-specific CRC natural-history models: Adenoma and Serrated pathway to Colorectal CAncer (ASCCA) and MIcrosimulation SCreening ANalysis for CRC (MISCAN-Colon) (both in the Netherlands), Policy1-Bowel (Australia) and OncoSim (Canada). Strategies assumed a 3-month screening disruption with varying recovery period lengths (6, 12, and 24 months) and varying FIT thresholds for diagnostic colonoscopy. Increasing the FIT threshold reduces the number of referrals to diagnostic colonoscopy. Outcomes for each strategy were colonoscopy demand and excess CRC-related deaths due to the disruption.nnRESULTS: Performing catch-up using the regular FIT threshold in 6, 12 and 24 months could prevent most excess CRC-related deaths, but required 50%, 25% and 12.5% additional colonoscopy demand, respectively. Without exceeding usual colonoscopy demand, up to 60% of excess CRC-related deaths can be prevented by increasing the FIT threshold for 12 or 24 months. Large increases in FIT threshold could lead to additional deaths rather than preventing them.nnCONCLUSIONS: Clearing the screening backlog in 24 months could avert most excess CRC-related deaths due to a 3-month disruption but would require a small increase in colonoscopy demand. Increasing the FIT threshold slightly over 24 months could ease the pressure on colonoscopy resources.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid35278030,

title = {Graphical Representation of Overlap for OVErviews: GROOVE tool},

author = {Pérez-Bracchiglione J and Meza N and Bangdiwala SI and Niño de Guzmán E and Urrútia G and Bonfill X and Madrid E},

doi = {10.1002/jrsm.1557},

issn = {1759-2887},

year  = {2022},

date = {2022-05-01},

journal = {Res Synth Methods},

volume = {13},

number = {3},

pages = {381--388},

abstract = {Overlap of primary studies among systematic reviews (SRs) is one of the main methodological challenges when conducting overviews. If not assessed properly, overlapped primary studies may mislead findings, since they may have a major influence either in qualitative analyses or in statistical weight. Moreover, overlapping SRs may represent the existence of duplicated efforts. Matrices of evidence and the calculation of the overall corrected covered area (CCA) are appropriate methods to address this issue, but they seem to be not comprehensive enough. In this article we present Graphical Representation of Overlap for OVErviews (GROOVE), an easy-to-use tool for overview authors. Starting from a matrix of evidence, GROOVE provides the number of included primary studies and SRs included in the matrix; the absolute number of overlapped and non-overlapped primary studies; and an overall CCA assessment. The tool also provides a detailed CCA assessment for each possible pair of SRs (or "nodes"), with a graphical and easy-to-read representation of these results. Additionally, it includes an advanced optional usage, incorporating structural missingness in the matrix. In this article, we show the details about how to use GROOVE, what results it achieves and how the tool obtains these results. GROOVE is intended to improve the overlap assessment by making it easier, faster, and more friendly for both authors and readers. The tool is freely available at http://doi.org/10.17605/OSF.IO/U2MS4 and https://es.cochrane.org/es/groovetool.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid34617681,

title = {The development of a core outcomes set for self-management interventions for patients living with obesity},

author = {Valli C and Suñol R and Orrego C and Niño de Guzmán E and Strammiello V and Adrion N and Immonen K and Ninov L and van der Gaag M and Ballester M and Alonso-Coello P},

doi = {10.1111/cob.12489},

issn = {1758-8111},

year  = {2022},

date = {2022-02-01},

journal = {Clin Obes},

volume = {12},

number = {1},

pages = {e12489},

abstract = {Self-management interventions (SMIs) can improve the life of patients living with obesity. However, there is variability in the outcomes used to assess the effectiveness of SMIs and these are often not relevant for patients. In the context of COMPAR-EU, our aim was to develop a core outcome set (COS) for the evaluation of SMIs for patients with obesity. We followed a four steps multimethod approach: (1) the development of the initial catalogue of outcomes; (2) a scoping review of reviews on patients' values and preferences on outcomes of self-management (SM); (3) a Delphi survey including patients and patient representatives to rate the importance of outcomes; and (4) a 2-day consensus workshop with patients, patient representatives, healthcare professionals and researchers. The initial catalogue included 82 outcomes. Ten patients and patient's representatives participated in the Delphi survey. We identified 16 themes through the thematic synthesis of the scoping review that informed 37.80% of the outcomes on initial catalogue. Five patients, five healthcare professionals, and four researchers participated in the consensus workshop. After the consensus process, 15 outcomes were selected to be part of the final COS, and five supplementary outcomes were also provided. We developed a COS for the evaluation of SMIs in obesity with a significant involvement of patients and other key stakeholders. This COS will help improving data synthesis and increasing the value of SM research data in healthcare decision making.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid34954239,

title = {Short-term impact of the COVID-19 pandemic on a population-based screening program for colorectal cancer in Catalonia (Spain)},

author = {Vives N and Binefa G and Vidal C and Milà N and Muñoz R and Guardiola V and Rial O and Garcia M},

doi = {10.1016/j.ypmed.2021.106929},

issn = {1096-0260},

year  = {2022},

date = {2022-02-01},

journal = {Prev Med},

volume = {155},

pages = {106929},

abstract = {The COVID-19 pandemic caused the suspension at all levels of the Catalan FIT-based CRC screening program on March 12, 2020. Screening invitations to FIT were resumed on September 1, 2020. We aimed to assess the short-term impact of the pandemic and describe strategies implemented to minimize harm by the disruption of the FIT-based CRC screening in the Metropolitan Area of Barcelona. We analyzed participation rate, colonoscopy adherence, time intervals to colonoscopy, detection rates, and advanced-stage cancers in 2019 and 2020. To identify perceived distress levels during the suspension of the screening we conducted a phone interview. As a result of the suspension, 43% of the individuals due for screening did not receive their invitation by December 31, 2020. A percent decrease of 5.1% in participation and of 8.9% in colonoscopy adherence among invitees between January-March was observed, with a recovery to 2019 levels when the screening activities were restarted. The time interval between a positive test to colonoscopy was longer in 2020 than in 2019. A decrease in advanced neoplasia rate and an increase in later stages of CRC were also observed. Individuals with a positive test did not report higher levels of perceived distress compared to those with a negative test. Although the disruption of screening had a temporary impact on participation and colonoscopy adherence, timing delay continues and a large backlog in the invitation of the target population remains. Thus, it is critical to implement strategies to minimize the long-term effects.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid35105575,

title = {Development of support material for health professionals who are implementing Shared Decision-making in breast cancer screening: validation using the Delphi technique},

author = {Hernández-Leal MJ and Codern-Bové N and Pérez-Lacasta MJ and Cardona A and Vidal-Lancis C and Carles-Lavila M and ProShare Group},

doi = {10.1136/bmjopen-2021-052566},

issn = {2044-6055},

year  = {2022},

date = {2022-02-01},

journal = {BMJ Open},

volume = {12},

number = {2},

pages = {e052566},

abstract = {BACKGROUND: The Literature is no report support material on Shared Decision-making applied to breast cancer screening that is intended for Spanish health professionals. The researcher created both a handbook and a guide for this topic using an adaption of the Three-talk model.nnOBJECTIVE: A Delphi method will be used to reach an agreement among experts on the contents and design of a manual and guide, designed by the research team, and to be used by health professionals in the application of SDM in breast cancer screening.nnDESIGN: A qualitative study. The content and design of the handbook and the guide was discussed by 20 experts. The Delphi techniques was in an online mode between July and October 2020 and researchers used Google forms in three rounds with open and closed questions. The criterion established for consensus was a coefficient of concordance (Cc) above 75, for questions using a Likert scale of 1-6-in which 1 meant 'completely disagree' and 6 'completely agree'-with a cut-off point equal to or higher than 4.nnRESULTS: Participants considered the Three-talk model suitable for the screening context. The handbook sections and level of detail were considered satisfactory (Cc=90). The summary provided by the clinical practice guide was considered necessary (Cc=75), as it was the self-assessment tool for professionals (Cc=85). Content was added: addressing the limitations of the SDM model; extending the number of sample dialogues for health professionals; providing supplementary resources on using Patient Decisions aids and adding references on communication skills.nnCONCLUSIONS AND APPLICATIONS: The first handbook and clinical practice guide providing unique SDM support material for health professionals have been developed. The handbook and guide are useful and innovative as supporting material for health professionals, but training strategies for SDM and a piloting plan for the use of materials are requested, in order to facilitate its implementation.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid35267461,

title = {Diagnostic Performance of a Fecal Immunochemical Test-Based Colorectal Cancer Screening Program According to Ambient Temperature and Humidity},

author = {Ibáñez-Sanz G and Milà N and Vives N and Vidal C and Binefa G and Rocamora J and Atencia C and Moreno V and Sanz-Pamplona R and Garcia M and On Behalf Of The Msic-Sc Research Group },

doi = {10.3390/cancers14051153},

issn = {2072-6694},

year  = {2022},

date = {2022-02-01},

journal = {Cancers (Basel)},

volume = {14},

number = {5},

abstract = {Exposure of the fecal immunochemical test (FIT) to different ambient temperatures and humidity is unavoidable in population-based screening programs in Southern European countries, and it could lead to a decrease in target colorectal lesions. The objective was to evaluate the effect of ambient temperature and humidity on the FIT sensitivity in a population-based screening program for colorectal cancer (CRC) using an ecological design. The retrospective cohort included individuals aged 50−69 years who participated in CRC screening (Barcelona) from 2010−2015, and were followed until 2017 to identify interval CRCs. The positivity rate, and detection rates for advanced polyps and CRC were compared according to ambient temperature, humidity, and quarters of the year. A positive FIT was defined as the detection of ≥20 μg Hb/g in feces. The monthly ambient temperature and humidity were recorded on the day that the FIT was performed. In total, 92,273 FIT results from 53,860 participants were analyzed. The FIT positivity rate was lower at >24 °C than at ≤24 °C (p = 0.005) but was not affected by humidity. The temperature’s impact on positivity did not lead to a decrease in the FIT detection rate for advanced neoplasia or the interval cancer detection rate in a program where the samples were refrigerated until the analysis and screening invitations were discontinued in July and August.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid35270331,

title = {Long-Term Risk of Breast Cancer after Diagnosis of Benign Breast Disease by Screening Mammography},

author = {Román M and Louro J and Posso M and Vidal C and Bargalló X and Vázquez I and Quintana MJ and Alcántara R and Saladié F and Del Riego J and Peñalva L and Sala M and Castells X and On Behalf Of The Bele And Iris Study Groups },

doi = {10.3390/ijerph19052625},

issn = {1660-4601},

year  = {2022},

date = {2022-02-01},

journal = {Int J Environ Res Public Health},

volume = {19},

number = {5},

abstract = {Assessing the long-term risk of breast cancer after diagnosis of benign breast disease by mammography is of utmost importance to design personalised screening strategies. We analysed individual-level data from 778,306 women aged 50-69 years with at least one mammographic screening participation in any of ten breast cancer screening centers in Spain from 1996 to 2015, and followed-up until 2017. We used Poisson regression to compare the rates of incident breast cancer among women with and without benign breast disease. During a median follow-up of 7.6 years, 11,708 (1.5%) women had an incident of breast cancer and 17,827 (2.3%) had a benign breast disease. The risk of breast cancer was 1.77 times higher among women with benign breast disease than among those without (95% CI: 1.61 to 1.95). The relative risk increased to 1.99 among women followed for less than four years, and remained elevated for two decades, with relative risk 1.96 (95% CI: 1.32 to 2.92) for those followed from 12 to 20 years. Benign breast disease is a long-term risk factor for breast cancer. Women with benign breast disease could benefit from closer surveillance and personalized screening strategies.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid34156554,

title = {Mammographic features of benign breast lesions and risk of subsequent breast cancer in women attending breast cancer screening},

author = {Posso M and Alcántara R and Vázquez I and Comerma L and Baré M and Louro J and Quintana MJ and Román M and Marcos-Gragera R and Vernet-Tomas M and Saladie F and Vidal C and Bargalló X and Peñalva L and Sala M and Castells X and BELE study group},

doi = {10.1007/s00330-021-08118-y},

issn = {1432-1084},

year  = {2022},

date = {2022-01-01},

journal = {Eur Radiol},

volume = {32},

number = {1},

pages = {621--629},

abstract = {OBJECTIVES: To evaluate the mammographic features in women with benign breast disease (BBD) and the risk of subsequent breast cancer according to their mammographic findings.nnMETHODS: We analyzed data from a Spanish cohort of women screened from 1995 to 2015 and followed up until December 2017 (median follow-up, 5.9 years). We included 10,650 women who had both histologically confirmed BBD and mammographic findings. We evaluated proliferative and nonproliferative BBD subtypes, and their mammographic features: architectural distortion, asymmetries, calcifications, masses, and multiple findings. The adjusted hazard ratios (aHR) and 95% confidence intervals (95% CI) for breast cancer were estimated using a Cox proportional hazards model. We plotted the adjusted cumulative incidence curves.nnRESULTS: Calcifications were more frequent in proliferative disease with atypia (43.9%) than without atypia (36.8%) or nonproliferative disease (22.2%; p value < 0.05). Masses were more frequent in nonproliferative lesions (59.1%) than in proliferative lesions without atypia (35.1%) or with atypia (30.0%; p value < 0.05). Multiple findings and architectural distortion were more likely in proliferative disease (16.1% and 4.7%) than in nonproliferative disease (12.8% and 1.9%). Subsequent breast cancer occurred in 268 (2.5%) women. Compared with women who had masses, the highest risk of subsequent breast cancer was found in those with architectural distortions (aHR, 2.21; 95% CI, 1.16-4.22), followed by those with multiple findings (aHR, 1.89; 95% CI, 1.34-2.66), asymmetries (aHR, 1.66; 95% CI, 0.84-3.28), and calcifications (aHR, 1.60; 95% CI, 1.21-2.12).nnCONCLUSION: BBD subtypes showed distinct mammographic findings. The risk of subsequent breast cancer was high in those who have shown architectural distortion, multiple findings, asymmetries, and calcifications than in women with masses.nnKEY POINTS: • The presence of mammographic findings in women attending breast cancer screening helps clinicians to assess women with benign breast disease (BBD). • Calcifications were frequent in BBDs with atypia, which are the ones with a high breast cancer risk, while masses were common in low-risk BBDs. • The excess risk of subsequent breast cancer in women with BBD was higher in those who showed architectural distortion compared to those with masses.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid34542055,

title = {Risk factors for lymphedema after breast surgery: A prospective cohort study in the era of sentinel lymph node biopsy},

author = {Salinas-Huertas S and Luzardo-González A and Vázquez-Gallego S and Pernas S and Falo C and Pla MJ and Gil-Gil M and Beranuy-Rodriguez M and Pérez-Montero H and Gomila-Sancho M and Manent-Molina N and Arencibia-Domínguez A and Gonzalez-Pineda B and Tormo-Collado F and Ortí-Asencio M and Terra J and Martinez-Perez E and Mestre-Jane A and Campos-Varela I and Jaraba-Armas M and Benítez-Segura A and Campos-Delgado M and Fernández-Montolí ME and Valverde-Alcántara Y and Rodríguez A and Campos G and Guma A and Ponce-Sebastià J and Planas-Balagué R and Catasús-Clavé M and García-Tejedor A},

doi = {10.3233/BD-210043},

issn = {1558-1551},

year  = {2022},

date = {2022-01-01},

journal = {Breast Dis},

volume = {41},

number = {1},

pages = {97--108},

abstract = {INTRODUCTION: The Objective was to investigate the incidence of lymphedema after breast cancer treatment and to analyze the risk factors involved in a tertiary level hospital.nnMETHODS: Prospective longitudinal observational study over 3 years post-breast surgery. 232 patients undergoing surgery for breast cancer at our institution between September 2013 and February 2018. Sentinel lymph node biopsy (SLNB) or axillary lymphadenectomy (ALND) were mandatory in this cohort. In total, 201 patients met the inclusion criteria and had a median follow-up of 31 months (range, 1-54 months). Lymphedema was diagnosed by circumferential measurements and truncated cone calculations. Patients and tumor characteristics, shoulder range of motion limitation and local and systemic therapies were analyzed as possible risk factors for lymphedema.nnRESULTS: Most cases of lymphedema appeared in the first 2 years. 13.9% of patients developed lymphedema: 31% after ALND and 4.6% after SLNB (p < 0.01), and 46.7% after mastectomy and 11.3% after breast-conserving surgery (p < 0.01). The lymphedema rate increased when axillary radiotherapy (RT) was added to radical surgery: 4.3% for SLNB alone, 6.7% for SLNB + RT, 17.6% for ALND alone, and 35.2% for ALND + RT (p < 0.01). In the multivariate analysis, the only risk factors associated with the development of lymphedema were ALND and mastectomy, which had hazard ratios (95% confidence intervals) of 7.28 (2.92-18.16) and 3.9 (1.60-9.49) respectively.nnCONCLUSIONS: The main risk factors for lymphedema were the more radical surgeries (ALND and mastectomy). The risk associated with these procedures appeared to be worsened by the addition of axillary radiotherapy. A follow-up protocol in patients with ALND lasting at least two years, in which special attention is paid to these risk factors, is necessary to guarantee a comprehensive control of lymphedema that provides early detection and treatment.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid34817770,

title = {Differences in breast cancer-risk factors between screen-detected and non-screen-detected cases (MCC-Spain study)},

author = {Hernández-García M and Molina-Barceló A and Vanaclocha-Espi M and Zurriaga Ó and Pérez-Gómez B and Aragonés N and Amiano P and Altzibar JM and Castaño-Vinyals G and Sala M and Ederra M and Martín V and Gómez-Acebo I and Vidal C and Tardón A and Marcos-Gragera R and Pollán M and Kogevinas M and Salas D},

doi = {10.1007/s10552-021-01511-4},

issn = {1573-7225},

year  = {2022},

date = {2022-01-01},

journal = {Cancer Causes Control},

volume = {33},

number = {1},

pages = {125--136},

abstract = {PURPOSE: The variation in breast cancer (BC)-risk factor associations between screen-detected (SD) and non-screen-detected (NSD) tumors has been poorly studied, despite the interest of this aspect in risk assessment and prevention. This study analyzes the differences in breast cancer-risk factor associations according to detection method and tumor phenotype in Spanish women aged between 50 and 69.nnMETHODS: We examined 900 BC cases and 896 controls aged between 50 and 69, recruited in the multicase-control MCC-Spain study. With regard to the cases, 460 were detected by screening mammography, whereas 144 were diagnosed by other means. By tumor phenotype, 591 were HR+, 153 were HER2+, and 58 were TN. Lifestyle, reproductive factors, family history of BC, and tumor characteristics were analyzed. Logistic regression models were used to compare cases vs. controls and SD vs. NSD cases. Multinomial regression models (controls used as a reference) were adjusted for case analysis according to phenotype and detection method.nnRESULTS: TN was associated with a lower risk of SD BC (OR 0.30 IC 0.10-0.89), as were intermediate (OR 0.18 IC 0.07-0.44) and advanced stages at diagnosis (OR 0.11 IC 0.03-0.34). Nulliparity in postmenopausal women and age at menopause were related to an increased risk of SD BC (OR 1.60 IC 1.08-2.36; OR 1.48 IC 1.09-2.00, respectively). Nulliparity in postmenopausal women was associated with a higher risk of HR+ (OR 1.66 IC 1.15-2.40). Age at menopause was related to a greater risk of HR+ (OR 1.60 IC 1.22-2.11) and HER2+ (OR 1.59 IC 1.03-2.45) tumors.nnCONCLUSION: Reproductive risk factors are associated with SD BC, as are HR+ tumors. Differences in BC-risk factor associations according to detection method may be related to prevailing phenotypes among categories.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid34848307,

title = {Post-polypectomy colonoscopy surveillance: Can we improve the diagnostic yield?},

author = {Ibáñez-Sanz G and Sanz-Pamplona R and Garcia M and PhD on behalf of the MSIC-SC research group},

doi = {10.1016/j.gastrohep.2021.11.005},

issn = {0210-5705},

year  = {2022},

date = {2022-01-01},

journal = {Gastroenterol Hepatol},

volume = {45},

number = {6},

pages = {474--487},

abstract = {Although adenomas and serrated polyps are the preneoplastic lesions of colorectal cancer, only few of them will eventually progress to cancer. This review provides a comprehensive overview of the present and future of post-polypectomy colonoscopy surveillance. Post-polypectomy surveillance guidelines have recently been updated and all share the aim towards more selective and less frequent surveillance. We have examined these current guidelines and compared the recommendations of each of them. To improve the diagnostic yield of post-polypectomy surveillance it is important to find predictors of metachronous polyps that better identify high-risk individuals of developing advanced neoplasia. For this reason, we have also conducted a literature review of the molecular biomarkers of metachronous advanced colorectal polyps. Finally, we have discussed future directions of post-polypectomy surveillance and identified possible strategies to improve the use of endoscopic resources with the COVID-19 pandemic.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid35572072,

title = {Stressful Life Events and Distress in Breast Cancer: A 5-Years Follow-Up},

author = {Ochoa-Arnedo C and Prats C and Travier N and Marques-Feixa L and Flix-Valle A and de Frutos ML and Domingo-Gil E and Medina JC and Serra-Blasco M},

doi = {10.1016/j.ijchp.2022.100303},

issn = {2174-0852},

year  = {2022},

date = {2022-01-01},

journal = {Int J Clin Health Psychol},

volume = {22},

number = {2},

pages = {100303},

abstract = {BACKGROUND/OBJECTIVE: Environmental factors such as psychosocial stress have demonstrated to have an impact on the breast cancer (BC) course. This study aims to explore the impact of psychotherapy and stressful life events (SLE) on BC survivors' illness trajectories.nnMETHOD: 68 women with BC underwent Positive Psychotherapy or Cognitive-Behavioral Stress Management and 37 patients were included as a control group. The effects of distress reduction and SLE on their 5-year recurrence were investigated. Additional analyses examined the effect of receiving vs. not receiving psychotherapy and of the type of therapy on survival and disease-free interval, DFI.nnRESULTS: A one-point decrease of the Hospital Anxiety and Depression Scale (HADS) after psychotherapy predicted a lower risk of 5-year recurrence,  = 0.84,  = .037, 95%  = 0.71-0.99). Also, a one point-increase in the number threatening SLE ( = 1.92;  = .028, 95%  = 1.07-3.43) was related to higher 5-year recurrence.nnCONCLUSIONS: The findings highlight the necessity of studying not only a given situation (i.e., psychotherapy, SLE) but its specific impact on individuals.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid33896656,

title = {[Health status among immigrant in Catalonia from a gender perspective: PELFI project]},

author = {Ferrer L and Gaillardin F and Cayuela A and Hernando C and Muñoz R and Sánchez N and Forero CG and Ronda E and Casabona J},

doi = {10.1016/j.gaceta.2021.02.010},

issn = {1578-1283},

year  = {2022},

date = {2022-01-01},

journal = {Gac Sanit},

volume = {36},

number = {4},

pages = {368--375},

abstract = {OBJECTIVE: The objective of the study is to assess the health status of immigrant men and women from non-EU countries living in the Metropolitan Area of Barcelona (Catalonia, Spain) and to identify the social determinants of health from a gender perspective.nnMETHOD: Cross-sectional analysis from a cohort of immigrant families recruited in Badalona and Santa Coloma de Gramenet, in Spain (PELFI cohort). In 2015-2016, 167 immigrants answered the baseline epidemiological questionnaire and the 5-level EuroQol instrument (EQ-5D) which measures health status. To identify health determinants, Tobit models were constructed to the EQ-5D index.nnRESULTS: Women rated poorer self-perceived health (p=0.005). To be diagnosed with and illness was only associated with poor self-perceived health among men (p<0.05). Length of residence, domestic work, and especially double workload deteriorated women's health. After adjusting models by demographics and social determinants, permanent administrative status (-0.136; p=0.015) and social support (0.182; p=0.02) were associated with health status in both sexes. To have a job was associated with better health only in men.nnCONCLUSIONS: Non-EU immigrants living in the Metropolitan Area of Barcelona are a socially vulnerable group of population and present inequalities in health by sex. Social support and occupation are key factors of their health status. Interventions to reduce immigrant vulnerabilities and inequalities in health should promote their social inclusion and cohesion from a gender perspective.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid35646791,

title = {Preferences Regarding Self-Management Intervention Outcomes of Dutch Chronically Ill Patients With Limited Health Literacy},

author = {van der Gaag M and Heijmans M and Ballester M and Orrego C and Niño de Guzmán E and Ninov L and Rademakers J},

doi = {10.3389/fpubh.2022.842462},

issn = {2296-2565},

year  = {2022},

date = {2022-01-01},

journal = {Front Public Health},

volume = {10},

pages = {842462},

abstract = {BACKGROUND: For many chronically ill patients self-management of their disease is difficult. This may be especially true for people with limited health literacy as they are faced with additional challenges in the day-to-day management of their disease. Research has shown that self-management support is most effective when tailored to the needs and preferences of patients. Therefore, this study explores the preferences regarding self-management outcomes of chronically ill patients with limited health literacy.nnMETHODS: A total of 35 patients with limited health literacy were invited to a concept-mapping procedure consisting of two card sorting tasks. Patients ranked 60 outcomes, which are often found in literature in relation to self-management, to the level that was important for themselves. Means were calculated for each outcome and domain, and differences within the group were analyzed.nnRESULTS: For patients with limited health literacy, satisfaction with care is the most important outcome domain. This domain includes overall satisfaction, the communication with health care providers, the provision of information and trust. At an outcome level, outcomes related to symptom management and improving competences to self-management scored very high. No differences between patient groups for age and sex were found.nnCONCLUSION: Chronically ill patients with limited health literacy prefer a wide variety of outcomes for their self-management. Next to health related outcomes, patients mostly prefer to work on their competences for self-management. For health care professionals, acting on these patient preferences and building a solid relationship will enhance successful self-management.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}