PUBLICACIONS

@article{pmid39408097,

title = {Health-Related Quality of Life in Long-Term Colorectal Cancer Survivors},

author = {Marcos-Delgado A and Martín-Sánchez V and Molina-Barceló A and Alonso-Molero J and Pérez-Gómez B and Pollán M and Aragonés N and Ederra-Sanza M and Fernández-Tardón G and Binefa G and Moreno V and Barrios-Rodríguez R and Amiano P and Huerta JM and Teso EP and Alguacil J and Castaño-Vinyals G and Kogevinas M and Molina de la Torre AJ},

doi = {10.3390/healthcare12191917},

issn = {2227-9032},

year  = {2024},

date = {2024-09-01},

journal = {Healthcare (Basel)},

volume = {12},

number = {19},

abstract = {The aim of our study is to evaluate the relationship between sociodemographic and clinical characteristics of individuals with Colorectal Cancer (CRC), tumour-intrinsic characteristics and treatment received with health-related quality of life (HRQoL).nnMETHODS: Cross-sectional analysis of data from 805 survivors from the MCC study was conducted. HRQoL was assessed through a general and specific questionnaire, SF-12 and FCSI (Colorectal Symptom Index). Statistical analyses were performed with linear regression with adjustment for sociodemographic variables, stage at diagnosis and histological grade.nnRESULTS: Participants had survived a median of 7.9 years from diagnosis (IQR 7.1-8.5 years). Age at diagnosis, sex and area showed a clear association with HRQoL in both physical and mental dimensions of the SF-12 questionnaire. A direct association between CRC recurrence was also found in the PCS-12 and MCS-12 dimensions and radical surgery in the PCS-12. Regarding the scores in FCSI questionnaire, statistically significant differences were observed by sex, age and area, with older women being the most impaired ( < 0.001).nnCONCLUSIONS: Age, sex and area was associated with lower scores of HRQoL among CRC survivors. Knowing the determinants related to HRQoL would allow us to lay the groundwork to develop strategies that help reduce morbidity and mortality, relapses and increase HRQoL.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Vives2024,

title = {The use of text messages as an alternative invitation method for breast cancer screening: A randomized controlled trial (M-TICS study)},

author = {Nuria Vives and Carmen Vidal and Ena Niño de Guzman and Albert Farre and Jon Aritz Panera and Gemma Binefa and Montse Garcia and },

editor = {Daniele Ugo Tari},

doi = {10.1371/journal.pone.0306720},

issn = {1932-6203},

year  = {2024},

date = {2024-08-29},

journal = {PLoS ONE},

volume = {19},

number = {8},

publisher = {Public Library of Science (PLoS)},

abstract = {This study aimed to determine whether a text message is as good as a postal letter as an invitation method for previous screenees in a breast cancer screening program, considering a non-inferiority margin of -2 percent points on participation rate. A non-inferiority randomized control trial was conducted. Women in the intervention group (n = 5,362) were invited by text message, and women in the control group (n = 5,482) were invited by letter, which is the standard invitation procedure of the program. In both groups, the invitation included a fixed appointment for mammography and a text message reminder 96 hours before the appointment. The primary outcome was screening participation rate (completing mammography within 12 weeks of invitation). Secondary outcomes included mammography attendance to initial or rescheduled appointments and cancellation rate. The intention-to-treat analysis showed a participation rate of 87.3% and 86.6% in the control and intervention groups, respectively. The difference in participation rate was -0.7 percentage points (95% confidence interval [CI], -1.8 to ∞), indicating non-inferiority of text messages compared to letter invitations. The per-protocol analysis showed similar results. Attendance at the initial appointment was higher in women who received the text message invitation compared to those in the control group (P<0.002). Women who received the invitation by letter canceled more the initial appointment scheduled compared to the text message group (21.1% and 15.1%, P<0.007). In conclusion, we found that a text message invitation for women who had previously participated in breast cancer screening was not inferior to the standard letter. This randomized controlled trial provides valuable insights into the use of alternative invitation methods for population-based cancer screening programs. However, further research is needed to determine the best timing and frequency of text messages for better outcomes and identify strategies for facilitating rescheduling or cancellation.

Trial Registration: Clinicaltrials.gov NCT04343950, (04/09/2020).},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39083331,

title = {Effectiveness and Acceptability of Targeted Text Message Reminders in Colorectal Cancer Screening: Randomized Controlled Trial (M-TICS Study)},

author = {Vives N and Travier N and Farre A and Binefa G and Vidal C and Pérez Lacasta MJ and Ibáñez-Sanz G and Niño de Guzmán EP and Panera JA and Garcia M and M-TICS Research Group},

doi = {10.2196/57959},

issn = {2369-2960},

year  = {2024},

date = {2024-07-01},

journal = {JMIR Public Health Surveill},

volume = {10},

pages = {e57959},

abstract = {BACKGROUND: Mobile phone-based SMS text message reminders have the potential to improve colorectal cancer screening participation rates.nnOBJECTIVE: This study assessed the effectiveness and acceptability of adding targeted SMS text message reminders to the standard procedure for those who picked up but did not return their screening kit at the pharmacy within 14 days in a colorectal cancer screening program in Catalonia, Spain.nnMETHODS: We performed a randomized control trial among individuals who picked up a fecal immunochemical test (FIT) kit for colorectal cancer screening at the pharmacy but did not return it within 14 days. The intervention group (n=4563) received an SMS text message reminder on the 14th day of kit pick up and the control group (n=4806) received no reminder. A 30-day reminder letter was sent to both groups if necessary. The main primary outcome was the FIT completion rate within 30, 60, and 126 days from FIT kit pick up (intention-to-treat analysis). A telephone survey assessed the acceptability and appropriateness of the intervention. The cost-effectiveness of adding an SMS text message reminder to FIT completion was also performed.nnRESULTS: The intervention group had higher FIT completion rates than the control group at 30 (64.2% vs 53.7%; P<.001), 60 (78.6% vs 72.0%; P<.001), and 126 (82.6% vs 77.7%; P<.001) days. Participation rates were higher in the intervention arm independent of sex, age, socioeconomic level, and previous screening behavior. A total of 339 (89.2%) interviewees considered it important and useful to receive SMS text message reminders for FIT completion and 355 (93.4%) preferred SMS text messages to postal letters. We observed a reduction of US $2.4 per participant gained in the intervention arm for invitation costs compared to the control arm.nnCONCLUSIONS: Adding an SMS text message reminder to the standard procedure significantly increased FIT kit return rates and was a cost-effective strategy. SMS text messages also proved to be an acceptable and appropriate communication channel for cancer screening programs.nnTRIAL REGISTRATION: ClinicalTrials.gov NCT04343950; https://www.clinicaltrials.gov/study/NCT04343950.nnINTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR2-10.1371/journal.pone.0245806.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38830535,

title = {Global review of COVID-19 mitigation strategies and their impact on cancer service disruptions},

author = {Shah R and Loo CE and Hanna NM and Hughes S and Mafra A and Fink H and McFerran E and Garcia M and Acharya S and Langselius O and Frick C and Niyigaba J and Lasebikan N and Steinberg J and Sullivan R and Bray F and Ilbawi AM and Ginsburg O and Chiam K and Cylus J and Caruana M and David M and Hui H and Canfell K and Soerjomataram I},

doi = {10.1016/j.jcpo.2024.100486},

issn = {2213-5383},

year  = {2024},

date = {2024-06-01},

journal = {J Cancer Policy},

volume = {41},

pages = {100486},

abstract = {During the COVID-19 pandemic, countries adopted mitigation strategies to reduce disruptions to cancer services. We reviewed their implementation across health system functions and their impact on cancer diagnosis and care during the pandemic. A systematic search was performed using terms related to cancer and COVID-19. Included studies reported on individuals with cancer or cancer care services, focusing on strategies/programs aimed to reduce delays and disruptions. Extracted data were grouped into four functions (governance, financing, service delivery, and resource generation) and sub-functions of the health system performance assessment framework. We included 30 studies from 16 countries involving 192,233 patients with cancer. Multiple mitigation approaches were implemented, predominantly affecting sub-functions of service delivery to control COVID-19 infection via the suspension of non-urgent cancer care, modified treatment guidelines, and increased telemedicine use in routine cancer care delivery. Resource generation was mainly ensured through adequate workforce supply. However, less emphasis on monitoring or assessing the effectiveness and financing of these strategies was observed. Seventeen studies suggested improved service uptake after mitigation implementation, yet the resulting impact on cancer diagnosis and care has not been established. This review emphasizes the importance of developing effective mitigation strategies across all health system (sub)functions to minimize cancer care service disruptions during crises. Deficiencies were observed in health service delivery (to ensure equity), governance (to monitor and evaluate the implementation of mitigation strategies), and financing. In the wake of future emergencies, implementation research studies that include pre-prepared protocols will be essential to assess mitigation impact across cancer care services.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38141149b,

title = {An Online HIV Self-Sampling Strategy for Gay, Bisexual and Other Men Who Have Sex with Men and Trans Women in Spain},

author = {Martínez-Riveros H and Díaz Y and Montoro-Fernandez M and Moreno-Fornés S and González V and Muntada E and Romano-deGea P and Muñoz R and Hoyos J and Casabona J and Agustí C},

doi = {10.1007/s10900-023-01311-8},

issn = {1573-3610},

year  = {2024},

date = {2024-06-01},

journal = {J Community Health},

volume = {49},

number = {3},

pages = {535--548},

abstract = {We aimed to evaluate the feasibility of an online self-sampling pilot intervention for HIV testing addressed to gay, bisexual, and other men who have sex with men (GBMSM) and trans women (TW) users of dating apps in Spain. The website https://www.testate.org/ was designed to offer self-sampling kits for HIV testing and online consultation of the results. It was advertised on gay dating apps. Participants requested the delivery of a saliva self-sampling kit by mail and a postage-paid envelope to send the sample to the reference laboratory. An anonymous acceptability survey was conducted. The cascade of care was estimated. From November 2018 to December 2021, 4623 individual users ordered self-sampling kits, 3097 returned an oral fluid sample to the reference laboratory (67.5% return rate). 87 reactive results were detected. 76 were confirmed to be HIV-positive, we estimated an HIV prevalence of 2.45% (95% CI 1.9-3.0%). 100% of those referred to specialized care are in treatment. 45.8% of participants took more than one test. 23 incident cases were detected among repeat testers, of which 20 were confirmed. The estimated incidence was 1.00 confirmed case per 100 individual-years of follow-up. 98.01% of participants would recommend it to a friend. The most identified advantages were convenience and privacy. We demonstrated that the online offer of oral self-sampling kits for HIV detection and reporting results online among GBMSM and TW users of dating apps is feasible. The intervention counted with a high acceptability and high efficacy (in terms of reactivity, confirmation and linkage to care rates).},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38083979b,

title = {Risk of COVID-19 death for people with a pre-existing cancer diagnosis prior to COVID-19-vaccination: A systematic review and meta-analysis},

author = {Steinberg J and Hughes S and Hui H and Allsop MJ and Egger S and David M and Caruana M and Coxeter P and Carle C and Onyeka T and Rewais I and Monroy Iglesias MJ and Vives N and Wei F and Abila DB and Carreras G and Santero M and O'Dowd EL and Lui G and Tolani MA and Mullooly M and Lee SF and Landy R and Hanley SJB and Binefa G and McShane CM and Gizaw M and Selvamuthu P and Boukheris H and Nakaganda A and Ergin I and Moraes FY and Timilshina N and Kumar A and Vale DB and Molina-Barceló A and Force LM and Campbell DJ and Wang Y and Wan F and Baker AL and Singh R and Salam RA and Yuill S and Shah R and Lansdorp-Vogelaar I and Yusuf A and Aggarwal A and Murillo R and Torode JS and Kliewer EV and Bray F and Chan KKW and Peacock S and Hanna TP and Ginsburg O and Van Hemelrijck M and Sullivan R and Roitberg F and Ilbawi AM and Soerjomataram I and Canfell K},

doi = {10.1002/ijc.34798},

issn = {1097-0215},

year  = {2024},

date = {2024-04-01},

journal = {Int J Cancer},

volume = {154},

number = {8},

pages = {1394--1412},

abstract = {While previous reviews found a positive association between pre-existing cancer diagnosis and COVID-19-related death, most early studies did not distinguish long-term cancer survivors from those recently diagnosed/treated, nor adjust for important confounders including age. We aimed to consolidate higher-quality evidence on risk of COVID-19-related death for people with recent/active cancer (compared to people without) in the pre-COVID-19-vaccination period. We searched the WHO COVID-19 Global Research Database (20 December 2021), and Medline and Embase (10 May 2023). We included studies adjusting for age and sex, and providing details of cancer status. Risk-of-bias assessment was based on the Newcastle-Ottawa Scale. Pooled adjusted odds or risk ratios (aORs, aRRs) or hazard ratios (aHRs) and 95% confidence intervals (95% CIs) were calculated using generic inverse-variance random-effects models. Random-effects meta-regressions were used to assess associations between effect estimates and time since cancer diagnosis/treatment. Of 23 773 unique title/abstract records, 39 studies were eligible for inclusion (2 low, 17 moderate, 20 high risk of bias). Risk of COVID-19-related death was higher for people with active or recently diagnosed/treated cancer (general population: aOR = 1.48, 95% CI: 1.36-1.61, I  = 0; people with COVID-19: aOR = 1.58, 95% CI: 1.41-1.77, I  = 0.58; inpatients with COVID-19: aOR = 1.66, 95% CI: 1.34-2.06, I  = 0.98). Risks were more elevated for lung (general population: aOR = 3.4, 95% CI: 2.4-4.7) and hematological cancers (general population: aOR = 2.13, 95% CI: 1.68-2.68, I  = 0.43), and for metastatic cancers. Meta-regression suggested risk of COVID-19-related death decreased with time since diagnosis/treatment, for example, for any/solid cancers, fitted aOR = 1.55 (95% CI: 1.37-1.75) at 1 year and aOR = 0.98 (95% CI: 0.80-1.20) at 5 years post-cancer diagnosis/treatment. In conclusion, before COVID-19-vaccination, risk of COVID-19-related death was higher for people with recent cancer, with risk depending on cancer type and time since diagnosis/treatment.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37516195b,

title = {How Do Patients With Type 2 Diabetes Mellitus Value the Importance of Outcomes? An Overview of Reviews},

author = {Niño-de-Guzmán E and Bracchiglione J and Vásquez-Mejía A and de Graaf G and Rocha Calderón C and Alonso-Coello P},

doi = {10.1016/j.jval.2023.07.003},

issn = {1524-4733},

year  = {2023},

date = {2023-12-01},

journal = {Value Health},

volume = {26},

number = {12},

pages = {1782--1794},

abstract = {OBJECTIVES: We aimed to assess how patients value the importance of type 2 diabetes mellitus (T2DM) related outcomes.nnMETHODS: Overview of systematic reviews (SRs) reporting patients' utilities or disutilities for T2DM outcomes. We searched 3 databases from inception until June 2021. Study selection and data extraction were conducted in pairs. We evaluated the quality of SRs with the Joanna Briggs Institute Checklist, and the overlap with the corrected covered area. We estimated descriptive statistics, and, when possible, conducted metanalysis.nnRESULTS: We identified 11 SRs, including 119 studies and 70 outcomes. Most reviews were high-quality SRs. The outcomes with the lowest utilities were hypoglycemia with very severe symptoms (acute complications), stroke (macrovascular complications), diabetic peripheral neuropathy with severe pain (microvascular complications), extreme obesity (comorbidities), and insulin only or combined (management of diabetes). Good/excellent glucose control and noninsulin injectable showed higher values than T2DM without complications. The outcomes with the highest disutilities were amputation, depression, major hypoglycemia, stroke, and management using only insulin.nnCONCLUSIONS: We provide standardized, reliable utility values (or associated disutilities) for T2DM, acute, microvascular and macrovascular complications, related comorbidities and treatments that may support judgments when making clinical recommendations, designing decision support tools, and developing interventions and economic analysis.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37537669,

title = {Patients' and informal caregivers' perspectives on self-management interventions for type 2 diabetes mellitus outcomes: a mixed-methods overview of 14 years of reviews},

author = {Niño-de-Guzman Quispe E and Bracchiglione J and Ballester M and Groene O and Heijmans M and Martínez García L and Noordman J and Orrego C and Rocha C and Suñol R and Alonso-Coello P},

doi = {10.1186/s13690-023-01153-9},

issn = {0778-7367},

year  = {2023},

date = {2023-08-01},

urldate = {2023-08-01},

journal = {Arch Public Health},

volume = {81},

number = {1},

pages = {140},

abstract = {BACKGROUND: Self-management interventions (SMIs) are core components of high-quality care in type 2 diabetes mellitus (T2DM). We aimed to identify and summarise the scientific evidence exploring the perspectives of patients with T2DM and their informal caregivers on outcomes of SMIs, and the key themes to enhance T2DM patient-centred care.nnMETHODS: We conducted a mixed-methods overview of reviews. We searched MEDLINE, CINAHL and PsycINFO, up to June 2021 for systematic reviews (SRs) exploring the perspectives of adults with T2DM and their informal caregivers, regarding self-management. Two reviewers conducted independently study selection, data extraction and quality assessment. We estimated the degree of overlap across SRs. We performed a qualitative analysis using a thematic synthesis approach.nnRESULTS: We identified 54 SRs, corresponding to 939 studies, with a slight overlap. Most SRs (47/54, 87%) were considered high quality. We developed summaries for 22 outcomes and identified six overarching themes: (1) diabetic identity; (2) accessing healthcare; (3) experience of care; (4) engagement with self-management; (5) outcomes awareness; and (6) challenges adhering to self-management. We found important variability in how patients with T2DM and their informal caregivers value critical outcomes influenced by the disease progression and several contextual factors.nnCONCLUSIONS: Our findings represent what matters most to patients with T2DM and their informal caregivers regarding outcomes of SMIs. Our results can facilitate the development and evaluation of SMIs, and guide decision-making in diabetes care, including the formulation of decisions and recommendations.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37538541,

title = {Potential global loss of life expected due to COVID-19 disruptions to organised colorectal cancer screening},

author = {Worthington J and van Wifferen F and Sun Z and de Jonge L and Lew JB and Greuter MJE and van den Puttelaar R and Feletto E and Lansdorp-Vogelaar I and Coupé VMH and Ein Yong JH and Canfell K and I-PaRCS Consortium},

doi = {10.1016/j.eclinm.2023.102081},

issn = {2589-5370},

year  = {2023},

date = {2023-08-01},

journal = {EClinicalMedicine},

volume = {62},

pages = {102081},

abstract = {BACKGROUND: Screening for colorectal cancer (CRC) decreases cancer burden through removal of precancerous lesions and early detection of cancer. The COVID-19 pandemic has disrupted organised CRC screening programs worldwide, with some programs completely suspending screening and others experiencing significant decreases in participation and diagnostic follow-up. This study estimated the global impact of screening disruptions on CRC outcomes, and potential effects of catch-up screening.nnMETHODS: Organised screening programs were identified in 29 countries, and data on participation rates and COVID-related changes to screening in 2020 were extracted where available. Four independent microsimulation models (ASCCA, MISCAN-Colon, OncoSim, and Policy1-Bowel) were used to estimate the long-term impact on CRC cases and deaths, based on decreases to screening participation in 2020. For countries where 2020 participation data were not available, changes to screening were approximated based on excess mortality rates. Catch-up strategies involving additional screening in 2021 were also simulated.nnFINDINGS: In countries for which direct data were available, organised CRC screening volumes at a country level decreased by an estimated 1.3-40.5% in 2020. Globally, it is estimated that COVID-related screening decreases led to a deficit of 7.4 million fewer faecal screens performed in 2020. In the absence of any organised catch-up screening, this would lead to an estimated 13,000 additional CRC cases and 7,900 deaths globally from 2020 to 2050; 79% of the additional cases and 85% of additional deaths could have been prevented with catch-up screening, respectively.nnINTERPRETATION: COVID-19-related disruptions to screening will cause excess CRC cases and deaths, but appropriately implemented catch-up screening could have reduced the burden by over 80%. Careful management of any disruption is key to improving the resilience of colorectal cancer screening programs.nnFUNDING: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by Cancer Council New South Wales, Health Canada, and Dutch National Institute for Public Health and Environment.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37217955,

title = {Characteristics and impact of interventions to support healthcare providers' compliance with guideline recommendations for breast cancer: a systematic literature review},

author = {Ricci-Cabello I and Carvallo-Castañeda D and Vásquez-Mejía A and Alonso-Coello P and Saz-Parkinson Z and Parmelli E and Morgano GP and Rigau D and Solà I and Neamtiu L and Niño-de-Guzmán E},

doi = {10.1186/s13012-023-01267-2},

issn = {1748-5908},

year  = {2023},

date = {2023-05-01},

journal = {Implement Sci},

volume = {18},

number = {1},

pages = {17},

abstract = {BACKGROUND: Breast cancer clinical practice guidelines (CPGs) offer evidence-based recommendations to improve quality of healthcare for patients. Suboptimal compliance with breast cancer guideline recommendations remains frequent, and has been associated with a decreased survival. The aim of this systematic review was to characterize and determine the impact of available interventions to support healthcare providers' compliance with CPGs recommendations in breast cancer healthcare.nnMETHODS: We searched for systematic reviews and primary studies in PubMed and Embase (from inception to May 2021). We included experimental and observational studies reporting on the use of interventions to support compliance with breast cancer CPGs. Eligibility assessment, data extraction and critical appraisal was conducted by one reviewer, and cross-checked by a second reviewer. Using the same approach, we synthesized the characteristics and the effects of the interventions by type of intervention (according to the EPOC taxonomy), and applied the GRADE framework to assess the certainty of evidence.nnRESULTS: We identified 35 primary studies reporting on 24 different interventions. Most frequently described interventions consisted in computerized decision support systems (12 studies); educational interventions (seven), audit and feedback (two), and multifaceted interventions (nine). There is low quality evidence that educational interventions targeted to healthcare professionals may improve compliance with recommendations concerning breast cancer screening, diagnosis and treatment. There is moderate quality evidence that reminder systems for healthcare professionals improve compliance with recommendations concerning breast cancer screening. There is low quality evidence that multifaceted interventions may improve compliance with recommendations concerning breast cancer screening. The effectiveness of the remaining types of interventions identified have not been evaluated with appropriate study designs for such purpose. There is very limited data on the costs of implementing these interventions.nnCONCLUSIONS: Different types of interventions to support compliance with breast cancer CPGs recommendations are available, and most of them show positive effects. More robust trials are needed to strengthen the available evidence base concerning their efficacy. Gathering data on the costs of implementing the proposed interventions is needed to inform decisions about their widespread implementation.nnTRIAL REGISTRATION: CRD42018092884 (PROSPERO).},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37418372,

title = {Piloting the informed health choices resources in Barcelona primary schools: A mixed methods study},

author = {Jofra LS and Alonso-Coello P and Martínez EC and de Britos Marsal C and Gallego Iborra A and Niño de Guzman Quispe EP and Pérez-Gaxiola G and Requeijo C and Roqué I Figuls M and Rosenbaum S and Salas-Gama K and Urreta-Barallobre I and Martínez García L},

doi = {10.1371/journal.pone.0288082},

issn = {1932-6203},

year  = {2023},

date = {2023-01-01},

journal = {PLoS One},

volume = {18},

number = {7},

pages = {e0288082},

abstract = {INTRODUCTION: The main objective of the Informed Health Choices (IHC) project is to teach people to assess treatment claims and make informed health choices. For this purpose, the IHC learning resources were developed for primary school children. The aim of this study is to explore students' and teachers' experience when using the IHC resources in primary schools in Barcelona (Spain).nnMETHODS: We conducted a mixed methods study for piloting the IHC resources in a convenience sample of primary schools in Barcelona. The intervention included a workshop with teachers, and nine lessons with students. We collected data using multiple approaches. We performed quantitative and qualitative analyses, and integrated the findings in a joint display. Finally, we formulated recommendations for using the IHC resources in this setting.nnRESULTS: Two schools, with a total of 143 students in 4th and 5th grade and six teachers, participated in the study. One school followed the suggested IHC teaching plan and competed all the lessons; the other school modified the plan substantially and did not complete all the lessons. Overall, students and teachers from both schools understood, were interested in, and were able to apply the content of the lessons. During the lessons, the textbook was useful for students; nevertheless, for the teachers, the usefulness of the IHC resources was variable. Teachers adapted the IHC resources to increase student participation and used Information and Communications Technologies tools. We observed more facilitators than barriers to teach the lessons. The teachers suggested some ideas to improve the lessons based on activities they developed and implemented. The integration analysis showed great convergence of the quantitative and qualitative findings. We propose seven recommendations for using the IHC resources in this setting.nnCONCLUSIONS: Students and teachers from primary schools in Barcelona showed a positive experience when using IHC resources; however, these resources should be adapted to promote classroom participation.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid36543351,

title = {Everything causes cancer? Beliefs and attitudes towards cancer prevention among anti-vaxxers, flat earthers, and reptilian conspiracists: online cross sectional survey},

author = {Paytubi S and Benavente Y and Montoliu A and Binefa G and Brotons M and Ibáñez R and Ochoa C and Peremiquel-Trillas P and Serrano B and Travier N and Alemany L and Costas L},

doi = {10.1136/bmj-2022-072561},

issn = {1756-1833},

year  = {2022},

date = {2022-12-01},

journal = {BMJ},

volume = {379},

pages = {e072561},

abstract = {OBJECTIVE: To evaluate, using an online non-probability sample, the beliefs about and attitudes towards cancer prevention of people professing vaccination scepticism or conspiracy theories.nnDESIGN: Cross sectional survey.nnSETTING: Data collected mainly from ForoCoches (a well known Spanish forum) and other platforms, including Reddit (English), 4Chan (English), HispaChan (Spanish), and a Spanish language website for cancer prevention (mejorsincancer.org) from January to March 2022.nnPARTICIPANTS: Among 1494 responders, 209 were unvaccinated against covid-19, 112 preferred alternative rather than conventional medicine, and 62 reported flat earth or reptilian beliefs.nnMAIN OUTCOME MEASURES: Cancer beliefs assessed using the Cancer Awareness Measure (CAM) and Cancer Awareness Measure Mythical Causes Scale (CAM-MYCS) (both validated tools).nnRESULTS: Awareness of the actual causes of cancer was greater (median CAM score 63.6%) than that of mythical causes (41.7%). The most endorsed mythical causes of cancer were eating food containing additives or sweeteners, feeling stressed, and eating genetically modified food. Awareness of the actual and mythical causes of cancer among the unvaccinated, alternative medicine, and conspiracy groups was lower than among their counterparts. A median of 54.5% of the actual causes was accurately identified among each of the unvaccinated, alternative medicine, and conspiracy groups, and a median of 63.6% was identified in each of the three corresponding counterparts (P=0.13, 0.04, and 0.003, respectively). For mythical causes, medians of 25.0%, 16.7%, and 16.7% were accurately identified in the unvaccinated, alternative medicine, and conspiracy groups, respectively; a median of 41.7% was identified in each of the three corresponding counterparts (P<0.001 in adjusted models for all comparisons). In total, 673 (45.0%) participants agreed with the statement "It seems like everything causes cancer." No significant differences were observed among the unvaccinated (44.0%), conspiracist (41.9%), or alternative medicine groups (35.7%), compared with their counterparts (45.2%, 45.7%, and 45.8%, respectively).nnCONCLUSIONS: Almost half of the participants agreed that "It seems like everything causes cancer," which highlights the difficulty that society encounters in differentiating actual and mythical causes owing to mass information. People who believed in conspiracies, rejected the covid-19 vaccine, or preferred alternative medicine were more likely to endorse the mythical causes of cancer than their counterparts but were less likely to endorse the actual causes of cancer. These results suggest a direct connection between digital misinformation and consequent erroneous health decisions, which may represent a further preventable fraction of cancer.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid36351714,

title = {Women's preference to apply shared decision-making in breast cancer screening: a discrete choice experiment},

author = {Hernández-Leal MJ and Pérez-Lacasta MJ and Cardona-Cardona A and Codern-Bové N and Vidal-Lancis C and Rue M and Forné C and Carles-Lavila M and Pro-Share Group},

doi = {10.1136/bmjopen-2022-064488},

issn = {2044-6055},

year  = {2022},

date = {2022-11-01},

journal = {BMJ Open},

volume = {12},

number = {11},

pages = {e064488},

abstract = {OBJECTIVE: To analyse women's stated preferences for establishing the relative importance of each attribute of shared decision-making (SDM) and their willingness to pay (WTP) for more participatory care in breast cancer screening programmes (BCSP).nnDESIGN: A discrete choice experiment was designed with 12 questions (choice tasks). It included three attributes: 'How the information is obtained', regarding benefits and harms; whether there is a 'Dialogue for scheduled mammography' between the healthcare professional and the woman; and, 'Who makes the decision', regarding participation in BCSP. Data were obtained using a survey that included 12 choice tasks, 1 question on WTP and 7 socioeconomic-related questions. The analysis was performed using conditional mixed-effect logit regression and stratification according to WTP.nnSETTING: Data collection related to BCSP was conducted between June and November 2021 in Catalonia, Spain.nnPARTICIPANTS: Sixty-five women aged between 50 and 60.nnMAIN OUTCOME MEASURES: Women's perceived utility of each attribute, trade-off on these attributes and WTP for SDM in BCSP.nnRESULT: The only significant attribute was 'Who makes the decision'. The decision made alone (coefficient=2.879; 95% CI=2.297 to 3.461) and the decision made together with a healthcare professional (2.375; 95% CI=1.573 to 3.177) were the options preferred by women. The former contributes 21% more utility than the latter. Moreover, 52.3% of the women stated a WTP of €10 or more for SDM. Women's preferences regarding attributes did not influence their WTP.nnCONCLUSIONS: The participant women refused a current paternalistic model and preferred either SDM or informed decision-making in BCSP.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid35963311,

title = {Guidance for setting international standards on reporting longitudinal adherence to stool-based colorectal cancer screening},

author = {van Wifferen F and Greuter MJE and Lissenberg-Witte BI and Carvalho B and Meijer GA and Dekker E and Campari C and Garcia M and Rabeneck L and Lansdorp-Vogelaar I and Senore C and Coupé VMH and ICSN Colorectal Cancer Screening Working Group},

doi = {10.1016/j.ypmed.2022.107187},

issn = {1096-0260},

year  = {2022},

date = {2022-11-01},

journal = {Prev Med},

volume = {164},

pages = {107187},

abstract = {Longitudinal adherence to colorectal cancer (CRC) screening is reported using different summarizing measures, which hampers international comparison. We provide evidence to guide recommendations on which longitudinal adherence measure to report. Using adherence data over four stool-based CRC screening rounds in three countries, we calculated six summarizing adherence measures; adherence over all rounds, adherence per round, rescreening, full programme adherence (yes/no), regularity (never/inconsistent/consistent screenees) and number of times participated. For each measure, we calculated the accuracy in capturing the observed adherence patterns. Using the ASCCA model, we predicted screening effectiveness when using summarizing measures as model input versus the observed adherence patterns. Adherence over all rounds in the Italian, Spanish and Dutch cohorts was 64.9%, 42.8% and 61.5%, respectively, and the proportion of consistent screenees was 50.9%, 26.3% and 45.7%. Number of times participated and regularity were most accurate and resulted in similar model-predicted screening effectiveness as simulating the observed adherence patterns of Italy, Spain and the Netherlands (mortality reductions: 24.4%, 16.9% and 23.5%). Adherence over all rounds and adherence per round were least accurate. Screening effectiveness was overestimated when using adherence over all rounds (mortality reductions: 26.8%, 19.4% and 25.7%) and adherence per round (mortality reductions: 26.8%, 19.5% and 25.9%). To conclude, number of times participated and regularity were most accurate and resulted in similar model-predicted screening effectiveness as using the observed adherence patterns. However they require longitudinal data. To facilitate international comparison of CRC screening programme performance, consensus on an accurate adherence measure to report should be reached.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid36113447,

title = {High HIV/STI prevalence among cisgender men and transgender women sex workers attending community-based centres in Barcelona, Spain: The Sweetie Project},

author = {Ferrer L and González V and Martró E and Folch C and Saludes V and Muñoz R and Rodríguez V and Morales A and Meroño M and Morey F and Sanjosé S and Casabona J},

doi = {10.1177/09564624221116536},

issn = {1758-1052},

year  = {2022},

date = {2022-10-01},

journal = {Int J STD AIDS},

volume = {33},

number = {12},

pages = {1045--1053},

abstract = {BACKGROUND: The aim of this study was to describe the socio-demographics, and the sexual and health-seeking behaviours of cisgender men and transgender women sex workers (M & TWSW) attending community-based organisations (CBOs) in Barcelona, Spain, as well as to estimate the prevalence of HIV, hepatitis B virus (HBV), hepatitis C virus (HCV),  (CT) and  (NG) among them at different anatomical sites.nnMETHODS: The Sweetie Project was a community-based cross-sectional study of 147 M & TWSW recruited in two CBOs in Barcelona between 2017 and 2018. A nurse collected biological samples from rectum, pharynx and urethra from the subjects at each CBO and the participants self-completed an epidemiological questionnaire.nnRESULTS: The highest prevalence observed was for HIV infection (25.3%) followed by bacterial STIs (NG 19.2% and CT 10.3%). The most prevalent anatomical site was pharyngeal (17.7%) followed by rectal (13.8%). More than half of participants who had a pharyngeal infection presented an isolated pharyngeal infection (57.7%) and half of those who had a rectal or urethral infection presented an isolated infection respectively. The seroprevalence of HCV and HBV was 2.4% and 34.2% respectively. There was a poor but statistically significant correlation between HIV and rectal CT infection ( = 0.31), previous exposure to HCV ( = 0.27) or self-reported STI ( = 0.23), as well as between previous exposure to HCV and rectal CT ( = 0.21) or self-reported STI ( = 0.20).nnDISCUSSION: The Sweetie Project confirms the high burden of HIV and bacterial STIs among a sample of M&TWSW recruited in CBOs and reinforces the need to routinely screen them at all exposed anatomical sites.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid35100894,

title = {Prioritisation of colonoscopy services in colorectal cancer screening programmes to minimise impact of COVID-19 pandemic on predicted cancer burden: A comparative modelling study},

author = {van Wifferen F and de Jonge L and Worthington J and Greuter MJE and Lew JB and Nadeau C and van den Puttelaar R and Feletto E and Yong JHE and Lansdorp-Vogelaar I and Canfell K and Coupé VMH and COVID-19 and Cancer Global Modelling Consortium (CCGMC) working group 2},

doi = {10.1177/09691413211056777},

issn = {1475-5793},

year  = {2022},

date = {2022-06-01},

journal = {J Med Screen},

volume = {29},

number = {2},

pages = {72--83},

abstract = {OBJECTIVES: Colorectal cancer (CRC) screening with a faecal immunochemical test (FIT) has been disrupted in many countries during the COVID-19 pandemic. Performing catch-up of missed screens while maintaining regular screening services requires additional colonoscopy capacity that may not be available. This study aimed to compare strategies that clear the screening backlog using limited colonoscopy resources.nnMETHODS: A range of strategies were simulated using four country-specific CRC natural-history models: Adenoma and Serrated pathway to Colorectal CAncer (ASCCA) and MIcrosimulation SCreening ANalysis for CRC (MISCAN-Colon) (both in the Netherlands), Policy1-Bowel (Australia) and OncoSim (Canada). Strategies assumed a 3-month screening disruption with varying recovery period lengths (6, 12, and 24 months) and varying FIT thresholds for diagnostic colonoscopy. Increasing the FIT threshold reduces the number of referrals to diagnostic colonoscopy. Outcomes for each strategy were colonoscopy demand and excess CRC-related deaths due to the disruption.nnRESULTS: Performing catch-up using the regular FIT threshold in 6, 12 and 24 months could prevent most excess CRC-related deaths, but required 50%, 25% and 12.5% additional colonoscopy demand, respectively. Without exceeding usual colonoscopy demand, up to 60% of excess CRC-related deaths can be prevented by increasing the FIT threshold for 12 or 24 months. Large increases in FIT threshold could lead to additional deaths rather than preventing them.nnCONCLUSIONS: Clearing the screening backlog in 24 months could avert most excess CRC-related deaths due to a 3-month disruption but would require a small increase in colonoscopy demand. Increasing the FIT threshold slightly over 24 months could ease the pressure on colonoscopy resources.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid35278030,

title = {Graphical Representation of Overlap for OVErviews: GROOVE tool},

author = {Pérez-Bracchiglione J and Meza N and Bangdiwala SI and Niño de Guzmán E and Urrútia G and Bonfill X and Madrid E},

doi = {10.1002/jrsm.1557},

issn = {1759-2887},

year  = {2022},

date = {2022-05-01},

journal = {Res Synth Methods},

volume = {13},

number = {3},

pages = {381--388},

abstract = {Overlap of primary studies among systematic reviews (SRs) is one of the main methodological challenges when conducting overviews. If not assessed properly, overlapped primary studies may mislead findings, since they may have a major influence either in qualitative analyses or in statistical weight. Moreover, overlapping SRs may represent the existence of duplicated efforts. Matrices of evidence and the calculation of the overall corrected covered area (CCA) are appropriate methods to address this issue, but they seem to be not comprehensive enough. In this article we present Graphical Representation of Overlap for OVErviews (GROOVE), an easy-to-use tool for overview authors. Starting from a matrix of evidence, GROOVE provides the number of included primary studies and SRs included in the matrix; the absolute number of overlapped and non-overlapped primary studies; and an overall CCA assessment. The tool also provides a detailed CCA assessment for each possible pair of SRs (or "nodes"), with a graphical and easy-to-read representation of these results. Additionally, it includes an advanced optional usage, incorporating structural missingness in the matrix. In this article, we show the details about how to use GROOVE, what results it achieves and how the tool obtains these results. GROOVE is intended to improve the overlap assessment by making it easier, faster, and more friendly for both authors and readers. The tool is freely available at http://doi.org/10.17605/OSF.IO/U2MS4 and https://es.cochrane.org/es/groovetool.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid35270331,

title = {Long-Term Risk of Breast Cancer after Diagnosis of Benign Breast Disease by Screening Mammography},

author = {Román M and Louro J and Posso M and Vidal C and Bargalló X and Vázquez I and Quintana MJ and Alcántara R and Saladié F and Del Riego J and Peñalva L and Sala M and Castells X and On Behalf Of The Bele And Iris Study Groups },

doi = {10.3390/ijerph19052625},

issn = {1660-4601},

year  = {2022},

date = {2022-02-01},

journal = {Int J Environ Res Public Health},

volume = {19},

number = {5},

abstract = {Assessing the long-term risk of breast cancer after diagnosis of benign breast disease by mammography is of utmost importance to design personalised screening strategies. We analysed individual-level data from 778,306 women aged 50-69 years with at least one mammographic screening participation in any of ten breast cancer screening centers in Spain from 1996 to 2015, and followed-up until 2017. We used Poisson regression to compare the rates of incident breast cancer among women with and without benign breast disease. During a median follow-up of 7.6 years, 11,708 (1.5%) women had an incident of breast cancer and 17,827 (2.3%) had a benign breast disease. The risk of breast cancer was 1.77 times higher among women with benign breast disease than among those without (95% CI: 1.61 to 1.95). The relative risk increased to 1.99 among women followed for less than four years, and remained elevated for two decades, with relative risk 1.96 (95% CI: 1.32 to 2.92) for those followed from 12 to 20 years. Benign breast disease is a long-term risk factor for breast cancer. Women with benign breast disease could benefit from closer surveillance and personalized screening strategies.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid35267461,

title = {Diagnostic Performance of a Fecal Immunochemical Test-Based Colorectal Cancer Screening Program According to Ambient Temperature and Humidity},

author = {Ibáñez-Sanz G and Milà N and Vives N and Vidal C and Binefa G and Rocamora J and Atencia C and Moreno V and Sanz-Pamplona R and Garcia M and On Behalf Of The Msic-Sc Research Group },

doi = {10.3390/cancers14051153},

issn = {2072-6694},

year  = {2022},

date = {2022-02-01},

journal = {Cancers (Basel)},

volume = {14},

number = {5},

abstract = {Exposure of the fecal immunochemical test (FIT) to different ambient temperatures and humidity is unavoidable in population-based screening programs in Southern European countries, and it could lead to a decrease in target colorectal lesions. The objective was to evaluate the effect of ambient temperature and humidity on the FIT sensitivity in a population-based screening program for colorectal cancer (CRC) using an ecological design. The retrospective cohort included individuals aged 50−69 years who participated in CRC screening (Barcelona) from 2010−2015, and were followed until 2017 to identify interval CRCs. The positivity rate, and detection rates for advanced polyps and CRC were compared according to ambient temperature, humidity, and quarters of the year. A positive FIT was defined as the detection of ≥20 μg Hb/g in feces. The monthly ambient temperature and humidity were recorded on the day that the FIT was performed. In total, 92,273 FIT results from 53,860 participants were analyzed. The FIT positivity rate was lower at >24 °C than at ≤24 °C (p = 0.005) but was not affected by humidity. The temperature’s impact on positivity did not lead to a decrease in the FIT detection rate for advanced neoplasia or the interval cancer detection rate in a program where the samples were refrigerated until the analysis and screening invitations were discontinued in July and August.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid35105575,

title = {Development of support material for health professionals who are implementing Shared Decision-making in breast cancer screening: validation using the Delphi technique},

author = {Hernández-Leal MJ and Codern-Bové N and Pérez-Lacasta MJ and Cardona A and Vidal-Lancis C and Carles-Lavila M and ProShare Group},

doi = {10.1136/bmjopen-2021-052566},

issn = {2044-6055},

year  = {2022},

date = {2022-02-01},

journal = {BMJ Open},

volume = {12},

number = {2},

pages = {e052566},

abstract = {BACKGROUND: The Literature is no report support material on Shared Decision-making applied to breast cancer screening that is intended for Spanish health professionals. The researcher created both a handbook and a guide for this topic using an adaption of the Three-talk model.nnOBJECTIVE: A Delphi method will be used to reach an agreement among experts on the contents and design of a manual and guide, designed by the research team, and to be used by health professionals in the application of SDM in breast cancer screening.nnDESIGN: A qualitative study. The content and design of the handbook and the guide was discussed by 20 experts. The Delphi techniques was in an online mode between July and October 2020 and researchers used Google forms in three rounds with open and closed questions. The criterion established for consensus was a coefficient of concordance (Cc) above 75, for questions using a Likert scale of 1-6-in which 1 meant 'completely disagree' and 6 'completely agree'-with a cut-off point equal to or higher than 4.nnRESULTS: Participants considered the Three-talk model suitable for the screening context. The handbook sections and level of detail were considered satisfactory (Cc=90). The summary provided by the clinical practice guide was considered necessary (Cc=75), as it was the self-assessment tool for professionals (Cc=85). Content was added: addressing the limitations of the SDM model; extending the number of sample dialogues for health professionals; providing supplementary resources on using Patient Decisions aids and adding references on communication skills.nnCONCLUSIONS AND APPLICATIONS: The first handbook and clinical practice guide providing unique SDM support material for health professionals have been developed. The handbook and guide are useful and innovative as supporting material for health professionals, but training strategies for SDM and a piloting plan for the use of materials are requested, in order to facilitate its implementation.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid34954239,

title = {Short-term impact of the COVID-19 pandemic on a population-based screening program for colorectal cancer in Catalonia (Spain)},

author = {Vives N and Binefa G and Vidal C and Milà N and Muñoz R and Guardiola V and Rial O and Garcia M},

doi = {10.1016/j.ypmed.2021.106929},

issn = {1096-0260},

year  = {2022},

date = {2022-02-01},

journal = {Prev Med},

volume = {155},

pages = {106929},

abstract = {The COVID-19 pandemic caused the suspension at all levels of the Catalan FIT-based CRC screening program on March 12, 2020. Screening invitations to FIT were resumed on September 1, 2020. We aimed to assess the short-term impact of the pandemic and describe strategies implemented to minimize harm by the disruption of the FIT-based CRC screening in the Metropolitan Area of Barcelona. We analyzed participation rate, colonoscopy adherence, time intervals to colonoscopy, detection rates, and advanced-stage cancers in 2019 and 2020. To identify perceived distress levels during the suspension of the screening we conducted a phone interview. As a result of the suspension, 43% of the individuals due for screening did not receive their invitation by December 31, 2020. A percent decrease of 5.1% in participation and of 8.9% in colonoscopy adherence among invitees between January-March was observed, with a recovery to 2019 levels when the screening activities were restarted. The time interval between a positive test to colonoscopy was longer in 2020 than in 2019. A decrease in advanced neoplasia rate and an increase in later stages of CRC were also observed. Individuals with a positive test did not report higher levels of perceived distress compared to those with a negative test. Although the disruption of screening had a temporary impact on participation and colonoscopy adherence, timing delay continues and a large backlog in the invitation of the target population remains. Thus, it is critical to implement strategies to minimize the long-term effects.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid34617681,

title = {The development of a core outcomes set for self-management interventions for patients living with obesity},

author = {Valli C and Suñol R and Orrego C and Niño de Guzmán E and Strammiello V and Adrion N and Immonen K and Ninov L and van der Gaag M and Ballester M and Alonso-Coello P},

doi = {10.1111/cob.12489},

issn = {1758-8111},

year  = {2022},

date = {2022-02-01},

journal = {Clin Obes},

volume = {12},

number = {1},

pages = {e12489},

abstract = {Self-management interventions (SMIs) can improve the life of patients living with obesity. However, there is variability in the outcomes used to assess the effectiveness of SMIs and these are often not relevant for patients. In the context of COMPAR-EU, our aim was to develop a core outcome set (COS) for the evaluation of SMIs for patients with obesity. We followed a four steps multimethod approach: (1) the development of the initial catalogue of outcomes; (2) a scoping review of reviews on patients' values and preferences on outcomes of self-management (SM); (3) a Delphi survey including patients and patient representatives to rate the importance of outcomes; and (4) a 2-day consensus workshop with patients, patient representatives, healthcare professionals and researchers. The initial catalogue included 82 outcomes. Ten patients and patient's representatives participated in the Delphi survey. We identified 16 themes through the thematic synthesis of the scoping review that informed 37.80% of the outcomes on initial catalogue. Five patients, five healthcare professionals, and four researchers participated in the consensus workshop. After the consensus process, 15 outcomes were selected to be part of the final COS, and five supplementary outcomes were also provided. We developed a COS for the evaluation of SMIs in obesity with a significant involvement of patients and other key stakeholders. This COS will help improving data synthesis and increasing the value of SM research data in healthcare decision making.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid35646791,

title = {Preferences Regarding Self-Management Intervention Outcomes of Dutch Chronically Ill Patients With Limited Health Literacy},

author = {van der Gaag M and Heijmans M and Ballester M and Orrego C and Niño de Guzmán E and Ninov L and Rademakers J},

doi = {10.3389/fpubh.2022.842462},

issn = {2296-2565},

year  = {2022},

date = {2022-01-01},

journal = {Front Public Health},

volume = {10},

pages = {842462},

abstract = {BACKGROUND: For many chronically ill patients self-management of their disease is difficult. This may be especially true for people with limited health literacy as they are faced with additional challenges in the day-to-day management of their disease. Research has shown that self-management support is most effective when tailored to the needs and preferences of patients. Therefore, this study explores the preferences regarding self-management outcomes of chronically ill patients with limited health literacy.nnMETHODS: A total of 35 patients with limited health literacy were invited to a concept-mapping procedure consisting of two card sorting tasks. Patients ranked 60 outcomes, which are often found in literature in relation to self-management, to the level that was important for themselves. Means were calculated for each outcome and domain, and differences within the group were analyzed.nnRESULTS: For patients with limited health literacy, satisfaction with care is the most important outcome domain. This domain includes overall satisfaction, the communication with health care providers, the provision of information and trust. At an outcome level, outcomes related to symptom management and improving competences to self-management scored very high. No differences between patient groups for age and sex were found.nnCONCLUSION: Chronically ill patients with limited health literacy prefer a wide variety of outcomes for their self-management. Next to health related outcomes, patients mostly prefer to work on their competences for self-management. For health care professionals, acting on these patient preferences and building a solid relationship will enhance successful self-management.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid33896656,

title = {[Health status among immigrant in Catalonia from a gender perspective: PELFI project]},

author = {Ferrer L and Gaillardin F and Cayuela A and Hernando C and Muñoz R and Sánchez N and Forero CG and Ronda E and Casabona J},

doi = {10.1016/j.gaceta.2021.02.010},

issn = {1578-1283},

year  = {2022},

date = {2022-01-01},

journal = {Gac Sanit},

volume = {36},

number = {4},

pages = {368--375},

abstract = {OBJECTIVE: The objective of the study is to assess the health status of immigrant men and women from non-EU countries living in the Metropolitan Area of Barcelona (Catalonia, Spain) and to identify the social determinants of health from a gender perspective.nnMETHOD: Cross-sectional analysis from a cohort of immigrant families recruited in Badalona and Santa Coloma de Gramenet, in Spain (PELFI cohort). In 2015-2016, 167 immigrants answered the baseline epidemiological questionnaire and the 5-level EuroQol instrument (EQ-5D) which measures health status. To identify health determinants, Tobit models were constructed to the EQ-5D index.nnRESULTS: Women rated poorer self-perceived health (p=0.005). To be diagnosed with and illness was only associated with poor self-perceived health among men (p<0.05). Length of residence, domestic work, and especially double workload deteriorated women's health. After adjusting models by demographics and social determinants, permanent administrative status (-0.136; p=0.015) and social support (0.182; p=0.02) were associated with health status in both sexes. To have a job was associated with better health only in men.nnCONCLUSIONS: Non-EU immigrants living in the Metropolitan Area of Barcelona are a socially vulnerable group of population and present inequalities in health by sex. Social support and occupation are key factors of their health status. Interventions to reduce immigrant vulnerabilities and inequalities in health should promote their social inclusion and cohesion from a gender perspective.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid35572072,

title = {Stressful Life Events and Distress in Breast Cancer: A 5-Years Follow-Up},

author = {Ochoa-Arnedo C and Prats C and Travier N and Marques-Feixa L and Flix-Valle A and de Frutos ML and Domingo-Gil E and Medina JC and Serra-Blasco M},

doi = {10.1016/j.ijchp.2022.100303},

issn = {2174-0852},

year  = {2022},

date = {2022-01-01},

journal = {Int J Clin Health Psychol},

volume = {22},

number = {2},

pages = {100303},

abstract = {BACKGROUND/OBJECTIVE: Environmental factors such as psychosocial stress have demonstrated to have an impact on the breast cancer (BC) course. This study aims to explore the impact of psychotherapy and stressful life events (SLE) on BC survivors' illness trajectories.nnMETHOD: 68 women with BC underwent Positive Psychotherapy or Cognitive-Behavioral Stress Management and 37 patients were included as a control group. The effects of distress reduction and SLE on their 5-year recurrence were investigated. Additional analyses examined the effect of receiving vs. not receiving psychotherapy and of the type of therapy on survival and disease-free interval, DFI.nnRESULTS: A one-point decrease of the Hospital Anxiety and Depression Scale (HADS) after psychotherapy predicted a lower risk of 5-year recurrence,  = 0.84,  = .037, 95%  = 0.71-0.99). Also, a one point-increase in the number threatening SLE ( = 1.92;  = .028, 95%  = 1.07-3.43) was related to higher 5-year recurrence.nnCONCLUSIONS: The findings highlight the necessity of studying not only a given situation (i.e., psychotherapy, SLE) but its specific impact on individuals.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid34848307,

title = {Post-polypectomy colonoscopy surveillance: Can we improve the diagnostic yield?},

author = {Ibáñez-Sanz G and Sanz-Pamplona R and Garcia M and PhD on behalf of the MSIC-SC research group},

doi = {10.1016/j.gastrohep.2021.11.005},

issn = {0210-5705},

year  = {2022},

date = {2022-01-01},

journal = {Gastroenterol Hepatol},

volume = {45},

number = {6},

pages = {474--487},

abstract = {Although adenomas and serrated polyps are the preneoplastic lesions of colorectal cancer, only few of them will eventually progress to cancer. This review provides a comprehensive overview of the present and future of post-polypectomy colonoscopy surveillance. Post-polypectomy surveillance guidelines have recently been updated and all share the aim towards more selective and less frequent surveillance. We have examined these current guidelines and compared the recommendations of each of them. To improve the diagnostic yield of post-polypectomy surveillance it is important to find predictors of metachronous polyps that better identify high-risk individuals of developing advanced neoplasia. For this reason, we have also conducted a literature review of the molecular biomarkers of metachronous advanced colorectal polyps. Finally, we have discussed future directions of post-polypectomy surveillance and identified possible strategies to improve the use of endoscopic resources with the COVID-19 pandemic.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid34817770,

title = {Differences in breast cancer-risk factors between screen-detected and non-screen-detected cases (MCC-Spain study)},

author = {Hernández-García M and Molina-Barceló A and Vanaclocha-Espi M and Zurriaga Ó and Pérez-Gómez B and Aragonés N and Amiano P and Altzibar JM and Castaño-Vinyals G and Sala M and Ederra M and Martín V and Gómez-Acebo I and Vidal C and Tardón A and Marcos-Gragera R and Pollán M and Kogevinas M and Salas D},

doi = {10.1007/s10552-021-01511-4},

issn = {1573-7225},

year  = {2022},

date = {2022-01-01},

journal = {Cancer Causes Control},

volume = {33},

number = {1},

pages = {125--136},

abstract = {PURPOSE: The variation in breast cancer (BC)-risk factor associations between screen-detected (SD) and non-screen-detected (NSD) tumors has been poorly studied, despite the interest of this aspect in risk assessment and prevention. This study analyzes the differences in breast cancer-risk factor associations according to detection method and tumor phenotype in Spanish women aged between 50 and 69.nnMETHODS: We examined 900 BC cases and 896 controls aged between 50 and 69, recruited in the multicase-control MCC-Spain study. With regard to the cases, 460 were detected by screening mammography, whereas 144 were diagnosed by other means. By tumor phenotype, 591 were HR+, 153 were HER2+, and 58 were TN. Lifestyle, reproductive factors, family history of BC, and tumor characteristics were analyzed. Logistic regression models were used to compare cases vs. controls and SD vs. NSD cases. Multinomial regression models (controls used as a reference) were adjusted for case analysis according to phenotype and detection method.nnRESULTS: TN was associated with a lower risk of SD BC (OR 0.30 IC 0.10-0.89), as were intermediate (OR 0.18 IC 0.07-0.44) and advanced stages at diagnosis (OR 0.11 IC 0.03-0.34). Nulliparity in postmenopausal women and age at menopause were related to an increased risk of SD BC (OR 1.60 IC 1.08-2.36; OR 1.48 IC 1.09-2.00, respectively). Nulliparity in postmenopausal women was associated with a higher risk of HR+ (OR 1.66 IC 1.15-2.40). Age at menopause was related to a greater risk of HR+ (OR 1.60 IC 1.22-2.11) and HER2+ (OR 1.59 IC 1.03-2.45) tumors.nnCONCLUSION: Reproductive risk factors are associated with SD BC, as are HR+ tumors. Differences in BC-risk factor associations according to detection method may be related to prevailing phenotypes among categories.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid34542055,

title = {Risk factors for lymphedema after breast surgery: A prospective cohort study in the era of sentinel lymph node biopsy},

author = {Salinas-Huertas S and Luzardo-González A and Vázquez-Gallego S and Pernas S and Falo C and Pla MJ and Gil-Gil M and Beranuy-Rodriguez M and Pérez-Montero H and Gomila-Sancho M and Manent-Molina N and Arencibia-Domínguez A and Gonzalez-Pineda B and Tormo-Collado F and Ortí-Asencio M and Terra J and Martinez-Perez E and Mestre-Jane A and Campos-Varela I and Jaraba-Armas M and Benítez-Segura A and Campos-Delgado M and Fernández-Montolí ME and Valverde-Alcántara Y and Rodríguez A and Campos G and Guma A and Ponce-Sebastià J and Planas-Balagué R and Catasús-Clavé M and García-Tejedor A},

doi = {10.3233/BD-210043},

issn = {1558-1551},

year  = {2022},

date = {2022-01-01},

journal = {Breast Dis},

volume = {41},

number = {1},

pages = {97--108},

abstract = {INTRODUCTION: The Objective was to investigate the incidence of lymphedema after breast cancer treatment and to analyze the risk factors involved in a tertiary level hospital.nnMETHODS: Prospective longitudinal observational study over 3 years post-breast surgery. 232 patients undergoing surgery for breast cancer at our institution between September 2013 and February 2018. Sentinel lymph node biopsy (SLNB) or axillary lymphadenectomy (ALND) were mandatory in this cohort. In total, 201 patients met the inclusion criteria and had a median follow-up of 31 months (range, 1-54 months). Lymphedema was diagnosed by circumferential measurements and truncated cone calculations. Patients and tumor characteristics, shoulder range of motion limitation and local and systemic therapies were analyzed as possible risk factors for lymphedema.nnRESULTS: Most cases of lymphedema appeared in the first 2 years. 13.9% of patients developed lymphedema: 31% after ALND and 4.6% after SLNB (p < 0.01), and 46.7% after mastectomy and 11.3% after breast-conserving surgery (p < 0.01). The lymphedema rate increased when axillary radiotherapy (RT) was added to radical surgery: 4.3% for SLNB alone, 6.7% for SLNB + RT, 17.6% for ALND alone, and 35.2% for ALND + RT (p < 0.01). In the multivariate analysis, the only risk factors associated with the development of lymphedema were ALND and mastectomy, which had hazard ratios (95% confidence intervals) of 7.28 (2.92-18.16) and 3.9 (1.60-9.49) respectively.nnCONCLUSIONS: The main risk factors for lymphedema were the more radical surgeries (ALND and mastectomy). The risk associated with these procedures appeared to be worsened by the addition of axillary radiotherapy. A follow-up protocol in patients with ALND lasting at least two years, in which special attention is paid to these risk factors, is necessary to guarantee a comprehensive control of lymphedema that provides early detection and treatment.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid34156554,

title = {Mammographic features of benign breast lesions and risk of subsequent breast cancer in women attending breast cancer screening},

author = {Posso M and Alcántara R and Vázquez I and Comerma L and Baré M and Louro J and Quintana MJ and Román M and Marcos-Gragera R and Vernet-Tomas M and Saladie F and Vidal C and Bargalló X and Peñalva L and Sala M and Castells X and BELE study group},

doi = {10.1007/s00330-021-08118-y},

issn = {1432-1084},

year  = {2022},

date = {2022-01-01},

journal = {Eur Radiol},

volume = {32},

number = {1},

pages = {621--629},

abstract = {OBJECTIVES: To evaluate the mammographic features in women with benign breast disease (BBD) and the risk of subsequent breast cancer according to their mammographic findings.nnMETHODS: We analyzed data from a Spanish cohort of women screened from 1995 to 2015 and followed up until December 2017 (median follow-up, 5.9 years). We included 10,650 women who had both histologically confirmed BBD and mammographic findings. We evaluated proliferative and nonproliferative BBD subtypes, and their mammographic features: architectural distortion, asymmetries, calcifications, masses, and multiple findings. The adjusted hazard ratios (aHR) and 95% confidence intervals (95% CI) for breast cancer were estimated using a Cox proportional hazards model. We plotted the adjusted cumulative incidence curves.nnRESULTS: Calcifications were more frequent in proliferative disease with atypia (43.9%) than without atypia (36.8%) or nonproliferative disease (22.2%; p value < 0.05). Masses were more frequent in nonproliferative lesions (59.1%) than in proliferative lesions without atypia (35.1%) or with atypia (30.0%; p value < 0.05). Multiple findings and architectural distortion were more likely in proliferative disease (16.1% and 4.7%) than in nonproliferative disease (12.8% and 1.9%). Subsequent breast cancer occurred in 268 (2.5%) women. Compared with women who had masses, the highest risk of subsequent breast cancer was found in those with architectural distortions (aHR, 2.21; 95% CI, 1.16-4.22), followed by those with multiple findings (aHR, 1.89; 95% CI, 1.34-2.66), asymmetries (aHR, 1.66; 95% CI, 0.84-3.28), and calcifications (aHR, 1.60; 95% CI, 1.21-2.12).nnCONCLUSION: BBD subtypes showed distinct mammographic findings. The risk of subsequent breast cancer was high in those who have shown architectural distortion, multiple findings, asymmetries, and calcifications than in women with masses.nnKEY POINTS: • The presence of mammographic findings in women attending breast cancer screening helps clinicians to assess women with benign breast disease (BBD). • Calcifications were frequent in BBDs with atypia, which are the ones with a high breast cancer risk, while masses were common in low-risk BBDs. • The excess risk of subsequent breast cancer in women with BBD was higher in those who showed architectural distortion compared to those with masses.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid34743725,

title = {Polygenic risk score across distinct colorectal cancer screening outcomes: from premalignant polyps to colorectal cancer},

author = {Obón-Santacana M and Díez-Villanueva A and Alonso MH and Ibáñez-Sanz G and Guinó E and López A and Rodríguez-Alonso L and Mata A and García-Rodríguez A and Palomo AG and Molina AJ and Garcia M and Binefa G and Martín V and Moreno V},

doi = {10.1186/s12916-021-02134-x},

issn = {1741-7015},

year  = {2021},

date = {2021-11-01},

journal = {BMC Med},

volume = {19},

number = {1},

pages = {261},

abstract = {BACKGROUND: Different risk-based colorectal cancer (CRC) screening strategies, such as the use of polygenic risk scores (PRS), have been evaluated to improve effectiveness of these programs. However, few studies have previously assessed its usefulness in a fecal immunochemical test (FIT)-based screening study.nnMETHODS: A PRS of 133 single nucleotide polymorphisms was assessed for 3619 participants: population controls, screening controls, low-risk lesions (LRL), intermediate-risk (IRL), high-risk (HRL), CRC screening program cases, and clinically diagnosed CRC cases. The PRS was compared between the subset of cases (n = 648; IRL+HRL+CRC) and controls (n = 956; controls+LRL) recruited within a FIT-based screening program. Positive predictive values (PPV), negative predictive values (NPV), and the area under the receiver operating characteristic curve (aROC) were estimated using cross-validation.nnRESULTS: The overall PRS range was 110-156. PRS values increased along the CRC tumorigenesis pathway (Mann-Kendall P value 0.007). Within the screening subset, the PRS ranged 110-151 and was associated with higher risk-lesions and CRC risk (OR 1.92, 95% CI 1.22-3.03). The cross-validated aROC of the PRS for cases and controls was 0.56 (95% CI 0.53-0.59). Discrimination was equal when restricted to positive FIT (aROC 0.56), but lower among negative FIT (aROC 0.55). The overall PPV among positive FIT was 0.48. PPV were dependent on the number of risk alleles for positive FIT (PPVp10-p90 0.48-0.57).nnCONCLUSIONS: PRS plays an important role along the CRC tumorigenesis pathway; however, in practice, its utility to stratify the general population or as a second test after a FIT positive result is still doubtful. Currently, PRS is not able to safely stratify the general population since the improvement on PPV values is scarce.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid34217412,

title = {The impact of the Covid-19 pandemic on breast cancer early detection and screening},

author = {Breast Screening Working Group (WG2) of the Covid-19 and Cancer Global Modelling Consortium and Figueroa JD and Gray E and Pashayan N and Deandrea S and Karch A and Vale DB and Elder K and Procopio P and van Ravesteyn NT and Mutabi M and Canfell K and Nickson C},

doi = {10.1016/j.ypmed.2021.106585},

issn = {1096-0260},

year  = {2021},

date = {2021-10-01},

journal = {Prev Med},

volume = {151},

pages = {106585},

abstract = {The COVID-19 pandemic affects mortality and morbidity, with disruptions expected to continue for some time, with access to timely cancer-related services a concern. For breast cancer, early detection and treatment is key to improved survival and longer-term quality of life. Health services generally have been strained and in many settings with population breast mammography screening, efforts to diagnose and treat breast cancers earlier have been paused or have had reduced capacity. The resulting delays to diagnosis and treatment may lead to more intensive treatment requirements and, potentially, increased mortality. Modelled evaluations can support responses to the pandemic by estimating short- and long-term outcomes for various scenarios. Multiple calibrated and validated models exist for breast cancer screening, and some have been applied in 2020 to estimate the impact of breast screening disruptions and compare options for recovery, in a range of international settings. On behalf of the Covid and Cancer Modelling Consortium (CCGMC) Working Group 2 (Breast Cancer), we summarize and provide examples of such in a range of settings internationally, and propose priorities for future modelling exercises. International expert collaborations from the CCGMC Working Group 2 (Breast Cancer) will conduct analyses and modelling studies needed to inform key stakeholders recovery efforts in order to mitigate the impact of the pandemic on early diagnosis and treatment of breast cancer.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid34352591,

title = {Health and economic impact at a population level of both primary and secondary preventive lung cancer interventions: A model-based cost-effectiveness analysis},

author = {Diaz M and Garcia M and Vidal C and Santiago A and Gnutti G and Gómez D and Trapero-Bertran M and Fu M and Lung Cancer Prevention LUCAPREV research group},

doi = {10.1016/j.lungcan.2021.06.027},

issn = {1872-8332},

year  = {2021},

date = {2021-09-01},

journal = {Lung Cancer},

volume = {159},

pages = {153--161},

abstract = {OBJECTIVES: Robust economic evaluations are needed to identify efficient strategies for lung cancer prevention that combine brief and intensive smoking cessation intervention programmes with screening using low-dose computed tomography (LDCT) at different ages, frequencies, and coverages. We aimed to assess the cost-effectiveness of smoking cessation approaches combined with lung cancer screening in the European context at a population level from a societal perspective.nnMATERIALS AND METHODS: A microsimulation model that describes the natural history of lung cancer and incorporates several prevention strategies was developed. Discounted lifetime QALYs and costs at a rate of 3% were used to calculate incremental cost-effectiveness ratios, defined as additional costs in 2017 Euros per QALY gained.nnRESULTS: Smoking cessation interventions reduce the incidence of lung cancer by 8%-46% and are consistently more effective and cost-effective when starting at younger ages. Screening reduces lung cancer mortality by 1%-24% and is generally less effective and more costly than smoking cessation interventions. The most cost-effective strategy would be to implement intensive smoking cessation interventions at ages 35, 40 and 45, combined with screening every three years between the ages of 55 and 65.nnCONCLUSIONS: Combining smoking cessation interventions with LDCT screening is a very attractive prevention strategy that substantially diminishes the burden of lung cancer. These combined prevention strategies, especially when providing several intensive interventions for smoking cessation at early ages, are more cost-effective than both approaches separately and allow for a more intensified LDCT without losing efficiency.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid33409776,

title = {Breast density, benign breast disease, and risk of breast cancer over time},

author = {Román M and Louro J and Posso M and Alcántara R and Peñalva L and Sala M and Del Riego J and Prieto M and Vidal C and Sánchez M and Bargalló X and Tusquets I and Castells X},

doi = {10.1007/s00330-020-07490-5},

issn = {1432-1084},

year  = {2021},

date = {2021-07-01},

journal = {Eur Radiol},

volume = {31},

number = {7},

pages = {4839--4847},

abstract = {OBJECTIVES: Assessing the combined effect of mammographic density and benign breast disease is of utmost importance to design personalized screening strategies.nnMETHODS: We analyzed individual-level data from 294,943 women aged 50-69 years with at least one mammographic screening participation in any of four areas of the Spanish Breast Cancer Screening Program from 1995 to 2015, and followed up until 2017. We used partly conditional Cox models to assess the association between benign breast disease, breast density, and the risk of breast cancer.nnRESULTS: During a median follow-up of 8.0 years, 3697 (1.25%) women had a breast cancer diagnosis and 5941 (2.01%) had a benign breast disease. More than half of screened women had scattered fibroglandular density (55.0%). The risk of breast cancer independently increased with the presence of benign breast disease and with the increase in breast density (p for interaction = 0.84). Women with benign breast disease and extremely dense breasts had a threefold elevated risk of breast cancer compared with those with scattered fibroglandular density and without benign breast disease (hazard ratio [HR] = 3.07; 95%CI = 2.01-4.68). Heterogeneous density and benign breast disease was associated with nearly a 2.5 elevated risk (HR = 2.48; 95%CI = 1.66-3.70). Those with extremely dense breast without a benign breast disease had a 2.27 increased risk (95%CI = 2.07-2.49).nnCONCLUSIONS: Women with benign breast disease had an elevated risk for over 15 years independently of their breast density category. Women with benign breast disease and dense breasts are at high risk for future breast cancer.nnKEY POINTS: • Benign breast disease and breast density were independently associated with breast cancer. • Women with benign breast disease had an elevated risk for up to 15 years independently of their mammographic density category.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid33422578,

title = {Role of community pharmacies in a population-based colorectal cancer screening program},

author = {Vives N and Milà N and Binefa G and Travier N and Farre A and Vidal C and Sattari M and Bagaria G and Garcia M},

doi = {10.1016/j.ypmed.2021.106420},

issn = {1096-0260},

year  = {2021},

date = {2021-04-01},

journal = {Prev Med},

volume = {145},

pages = {106420},

abstract = {In Catalonia (Spain), population-based colorectal cancer (CRC) screening offers biennial fecal occult blood testing to men and women aged 50-69 years old. The program is organized in screening hubs, most of which use a pharmacy-based model to distribute and collect fecal immunochemical test (FIT) kits The comprehensive evaluation of CRC screening programs, which include the role and implications of pharmacy involvement, is essential to ensure program quality and identify areas for further improvement. The present study aimed to assess the adherence of community pharmacies to the CRC screening program and to analyze data on FIT kit distribution and collection in the Metropolitan area of Barcelona (Catalonia, Spain). Time to FIT completion was assessed by Kaplan-Meier estimation, and with the log-rank test. A Cox regression model was used to adjust for other variables associated with the completion of FIT such as sex, age, deprivation score index and previous screening behavior. Overall, 82.4% of pharmacies adhered with CRC screening program. Out of 82,902 FIT kits distributed to screening invitees 77,524 completed FIT kits were returned to pharmacies (93.5%) with a participation of 39.8% among the 193,766 invitees. From those who completed a FIT, the median time to return the kit was 3 days. FIT completion time was significantly lower among women, older age, high deprivation score index and previous CRC screening (p < 0.005). Our findings highlight the large involvement of community pharmacists with CRC screening program as well as a high quality in the process of FIT distribution and collection.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid33809520,

title = {Future Prospects of Colorectal Cancer Screening: Characterizing Interval Cancers},

author = {Ibáñez-Sanz G and Sanz-Pamplona R and Garcia M and On Behalf Of The Msic-Sc Research Group },

doi = {10.3390/cancers13061328},

issn = {2072-6694},

year  = {2021},

date = {2021-03-01},

journal = {Cancers (Basel)},

volume = {13},

number = {6},

abstract = {Tumors that are not detected by screening tests are known as interval cancers and are diagnosed clinically after a negative result in the screening episode but before the next screening invitation. Clinical characteristics associated with interval colorectal cancers have been studied, but few molecular data are available that describe interval colorectal cancers. A better understanding of the clinical and biological characteristics associated with interval colorectal cancer may provide new insights into how to prevent this disease more effectively. This review aimed to summarize the current literature concerning interval colorectal cancer and its epidemiological, clinical, and molecular features.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid33358209,

title = {Risk of breast cancer two years after a benign biopsy depends on the mammographic feature prompting recall},

author = {Vernet-Tomás M and Louro J and Román M and Saladié F and Posso M and Prieto M and Vázquez I and Baré M and Peñalva L and Vidal C and Bargalló X and Sánchez M and Ferrer J and A Espinàs J and Quintana MJ and Rodríguez-Arana A and Castells X and BELE study group},

doi = {10.1016/j.maturitas.2020.10.024},

issn = {1873-4111},

year  = {2021},

date = {2021-02-01},

journal = {Maturitas},

volume = {144},

pages = {53--59},

abstract = {OBJECTIVE: We aimed to explore whether the type of mammographic feature prompting a false-positive recall (FPR) during mammography screening influences the risk and timing of breast cancer diagnosis, particularly if assessed with invasive procedures.nnSTUDY DESIGN: We included information on women screened and recalled for further assessment in Spain between 1994 and 2015, with follow-up until 2017, categorizing FPRs by the assessment (noninvasive or invasive) and mammographic feature prompting the recall.nnMAIN OUTCOME MEASURES: Breast cancer rates in the first two years after FPR (first period) and after two years (second period).nnRESULTS: The study included 99,825 women with FPRs. In both periods, the breast cancer rate was higher in the invasive assessment group than in the noninvasive group (first period 12 ‰ vs 1.9 ‰, p < 0.001; second period 4.4‰ vs 3.1‰, p < 0.001). During the first period, the invasive assessment group showed diverse breast cancer rates for each type of mammographic feature, with a higher rate for asymmetric density (31.9‰). When the second period was compared with the first, the breast cancer rate decreased in the invasive assessment group (from 12‰ to 4.4‰, p < 0.001) and increased in the noninvasive assessment group (from 1.9‰ to 3.1‰, p < 0.001).nnCONCLUSION: In the context of mammography screening, the risk of breast cancer diagnosis during the first two years after FPR was particularly high for women undergoing invasive assessment; importantly, the risk was modified by type of mammographic feature prompting the recall. This information could help to individualize follow-up after exclusion of malignancy.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid33755692,

title = {Developing and validating an individualized breast cancer risk prediction model for women attending breast cancer screening},

author = {Louro J and Román M and Posso M and Vázquez I and Saladié F and Rodriguez-Arana A and Quintana MJ and Domingo L and Baré M and Marcos-Gragera R and Vernet-Tomas M and Sala M and Castells X and BELE and IRIS Study Groups},

doi = {10.1371/journal.pone.0248930},

issn = {1932-6203},

year  = {2021},

date = {2021-01-01},

journal = {PLoS One},

volume = {16},

number = {3},

pages = {e0248930},

abstract = {BACKGROUND: Several studies have proposed personalized strategies based on women's individual breast cancer risk to improve the effectiveness of breast cancer screening. We designed and internally validated an individualized risk prediction model for women eligible for mammography screening.nnMETHODS: Retrospective cohort study of 121,969 women aged 50 to 69 years, screened at the long-standing population-based screening program in Spain between 1995 and 2015 and followed up until 2017. We used partly conditional Cox proportional hazards regression to estimate the adjusted hazard ratios (aHR) and individual risks for age, family history of breast cancer, previous benign breast disease, and previous mammographic features. We internally validated our model with the expected-to-observed ratio and the area under the receiver operating characteristic curve.nnRESULTS: During a mean follow-up of 7.5 years, 2,058 women were diagnosed with breast cancer. All three risk factors were strongly associated with breast cancer risk, with the highest risk being found among women with family history of breast cancer (aHR: 1.67), a proliferative benign breast disease (aHR: 3.02) and previous calcifications (aHR: 2.52). The model was well calibrated overall (expected-to-observed ratio ranging from 0.99 at 2 years to 1.02 at 20 years) but slightly overestimated the risk in women with proliferative benign breast disease. The area under the receiver operating characteristic curve ranged from 58.7% to 64.7%, depending of the time horizon selected.nnCONCLUSIONS: We developed a risk prediction model to estimate the short- and long-term risk of breast cancer in women eligible for mammography screening using information routinely reported at screening participation. The model could help to guiding individualized screening strategies aimed at improving the risk-benefit balance of mammography screening programs.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid34191813,

title = {Positive impact of a faecal-based screening programme on colorectal cancer mortality risk},

author = {Ibáñez-Sanz G and Milà N and Vidal C and Rocamora J and Moreno V and Sanz-Pamplona R and Garcia M and MSIC-SC research group},

doi = {10.1371/journal.pone.0253369},

issn = {1932-6203},

year  = {2021},

date = {2021-01-01},

journal = {PLoS One},

volume = {16},

number = {6},

pages = {e0253369},

abstract = {INTRODUCTION: The effectiveness of colorectal cancer (CRC) screening programs is directly related to participation and the number of interval CRCs. The objective was to analyse specific-mortality in a cohort of individuals invited to a CRC screening program according to type of CRC diagnosis (screen-detected cancers, interval cancers, and cancers among the non-uptake group).nnMATERIAL AND METHODS: Retrospective cohort that included invitees aged 50-69 years of a CRC screening program (target population of 85,000 people) in Catalonia (Spain) from 2000-2015 with mortality follow-up until 2020. A screen-detected CRC was a cancer diagnosed after a positive faecal occult blood test (guaiac or immunochemical); an interval cancer was a cancer diagnosed after a negative test result and before the next invitation to the program (≤24 months); a non-uptake cancer was a cancer in subjects who declined screening.nnRESULTS: A total of 624 people were diagnosed with CRC (n = 265 screen-detected, n = 103 interval cancers, n = 256 non-uptake). In the multivariate analysis, we observed a 74% increase in mortality rate in the group with interval CRC compared to screen-detected CRC adjusted for age, sex, location and stage (HR: 1.74%, 95% CI:1.08-2.82, P = 0.02). These differences were found even when we restricted for advanced-cancers participants. In the stratified analysis for type of faecal occult blood test, a lower mortality rate was only observed among FIT screen-detected CRCs.nnCONCLUSION: CRC screening with the FIT was associated with a significant reduction in CRC mortality.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid32151468,

title = {Outreach HIV testing using oral fluid and online consultation of the results: Pilot intervention in Catalonia},

author = {Agustí C and Muñoz R and González V and Villegas L and Fibla J and Meroño M and Capitán A and Fernàndez-López L and Platteau T and Casabona J},

doi = {10.1016/j.eimc.2020.01.020},

issn = {2529-993X},

year  = {2021},

date = {2021-01-01},

journal = {Enferm Infecc Microbiol Clin (Engl Ed)},

volume = {39},

number = {1},

pages = {3--8},

abstract = {INTRODUCTION: The aim of the intervention was to describe the feasibility and cost-effectiveness of offering HIV testing in outreach interventions and subsequent consultation of the results through a secure web page.nnMETHODS: The HIV test was offered "in situ" to men who have sex with men (MSM), migrant sex workers and trans women recruited in places of leisure and sex. Four collaborating NGOs recruited the participants and assisted them to register on the study website (www.swab2know.eu) through a tablet or the smartphone of the same participant. The samples were sent to the reference laboratory and the results were published on the website.nnRESULTS: 834 participants (612 MSMs, 203 women sex workers and 19 trans women) were recruited. In total 22 reagent results (2.6%) were detected: 21 among MSMs (3.4%) and 1 in a trans women (5.3%). While 82.6% of MSMs consulted their outcome, only 39.9% and 26.3% of women sex workers and trans women respectively consulted their outcome CONCLUSIONS: Providing self-sampling in outreach activities, dispatch and analysis in a reference laboratory as well as online communication of test results is feasible. A high proportion of participants with a HIV reactive result were detected among MSMs and trans women.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid33159805,

title = {Proton-pump inhibitors are associated with a high false-positivity rate in faecal immunochemical testing},

author = {Ibáñez-Sanz G and Milà N and de la Peña-Negro LC and Garcia M and Vidal C and Rodríguez-Alonso L and Binefa G and Rodríguez-Moranta F and Moreno V},

doi = {10.1007/s00535-020-01738-z},

issn = {1435-5922},

year  = {2021},

date = {2021-01-01},

journal = {J Gastroenterol},

volume = {56},

number = {1},

pages = {42--53},

abstract = {BACKGROUND: False-positivity rates in faecal immunochemical test (FIT) can be affected by drug exposure. We aimed to assess the association between proton pump inhibitors (PPI) consumption and false positive (FP) results in a colorectal cancer (CRC) screening programme using electronic prescription records.nnMETHODS: A retrospective cohort study within a population-based screening program for CRC from 2010 to 2016 was performed. Participants with a conclusive FIT result and with prescription electronic data were included. An FP result was defined as having a positive FIT (≥ 20 µg haemoglobin/g faeces) and a follow-up colonoscopy without intermediate or high-risk lesions or CRC. Screening data were anonymously linked to the public data analysis program for health research and innovation (PADRIS) database that recorded patient diseases history and reimbursed medication. PPI exposure was defined as having retrieved at least one dispensation of PPI three months prior to the FIT.nnRESULTS: A total of 89,199 tests (of 46,783 participants) were analysed, 4824 (5.4%) tested positive and the proportion of FP was 53.5%. Overall, 17,544 participants (19.7%) were PPI users prior to FIT performance. PPI exposure increased the probability of obtaining an FP FIT result from 50.4 to 63.3% (adjusted OR 1.39; 95% CI 1.18-1.65). Nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, antibiotics, and laxatives were also associated with an FP result. The effect of PPI was independent and showed a synergistic interaction with nonsteroidal anti-inflammatory drugs.nnCONCLUSION: PPIs increase FIT positivity at the expense of FP results. The recommendation to avoid their use before FIT performance could reduce up to 3% of colonoscopies and 9% of FP results.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid32173050,

title = {[Informed choice in breast cancer screening: the role of education]},

author = {Pons-Rodríguez A and Martínez-Alonso M and Perestelo-Pérez L and Garcia M and Sala M and Rué M and en nombre del grupo InforMa and El grupo InforMa está formado por},

doi = {10.1016/j.gaceta.2020.01.002},

issn = {1578-1283},

year  = {2021},

date = {2021-01-01},

journal = {Gac Sanit},

volume = {35},

number = {3},

pages = {243--249},

abstract = {OBJECTIVE: To evaluate the effect of receiving information about the benefits and harms of breast cancer screening in informed choice, according to educational level.nnMETHOD: Secondary analysis of a randomized, controlled study, in four screening programs, in Catalonia and the Canary Islands (Spain). We analyzed 400 women who were going to be invited to participate for the first time. The intervention group received a decision aid that showed the benefits and harms of screening. The control group received a standard brochure that recommended participating in the screening program. Educational level was grouped into two categories, low and high. The primary outcome was informed choice defined as adequate knowledge and consistency between attitudes and intentions.nnRESULTS: The intervention produced a greater increase in knowledge in women with a high educational level compared to those with a lower educational level. Among women who received the intervention, informed choice was almost three times higher in those with a high educational level (27% versus 11%). No differences were observed between educational levels in decisional conflict, confidence in the decision, anxiety and worry about breast cancer, in the intervention and control groups.nnCONCLUSIONS: A decision aid for breast cancer screening had much more impact on informed choice among women with a high educational level. In women with low educational level, the attitude towards screening improved and there was an increase in the intention to be screened.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid33481914,

title = {Text messaging as a tool to improve cancer screening programs (M-TICS Study): A randomized controlled trial protocol},

author = {Vives N and Farre A and Ibáñez-Sanz G and Vidal C and Binefa G and Milà N and Pérez-Lacasta MJ and Travier N and Benito L and Espinàs JA and Bagaria G and Garcia M},

doi = {10.1371/journal.pone.0245806},

issn = {1932-6203},

year  = {2021},

date = {2021-01-01},

journal = {PLoS One},

volume = {16},

number = {1},

pages = {e0245806},

abstract = {BACKGROUND: Short message service (SMS) based interventions are widely used in healthcare and have shown promising results to improve cancer screening programs. However, more research is still needed to implement SMS in the screening process. We present a study protocol to assess the impact on health and economics of three targeted SMS-based interventions in population-based cancer screening programs.nnMETHODS/DESIGN: The M-TICs study is a randomized controlled trial with a formal process evaluation. Participants aged 50-69 years identified as eligible from the colorectal cancer (CRC) and breast cancer (BC) screening program of the Catalan Institute of Oncology (Catalonia, Spain) will be randomly assigned to receive standard invitation procedure (control group) or SMS-based intervention to promote participation. Two interventions will be conducted in the CRC screening program: 1) Screening invitation reminder: Those who do not participate in the CRC screening within 6 weeks of invite will receive a reminder (SMS or letter); 2) Reminder to complete and return fecal immunochemical test (FIT) kit: SMS reminder versus no intervention to individuals who have picked up a FIT kit at the pharmacy and they have not returned it after 14 days. The third intervention will be performed in the BC screening program. Women who had been screened previously will receive an SMS invitation or a letter invitation to participate in the screening. As a primary objective we will assess the impact on participation for each intervention. The secondary objectives will be to analyze the cost-effectiveness of the interventions and to assess participants' perceptions.nnEXPECTED RESULTS: The results from this randomized controlled trial will provide important empirical evidence for the use of mobile phone technology as a tool for improving population-based cancer screening programs. These results may influence the cancer screening invitation procedure in future routine practice.nnTRIAL REGISTRATION: Registry: NCT04343950 (04/09/2020); clinicaltrials.gov.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid33496270,

title = {[Inequalities in access to cancer screening programmes in Spain and how to reduce them: data from 2013 and 2020.]},

author = {Molina-Barceló A and Moreno Salas J and Peiró-Pérez R and Arroyo G and Ibáñez Cabanell J and Vanaclocha Espí M and Binefa G and García M and Salas Trejo D},

issn = {2173-9110},

year  = {2021},

date = {2021-01-01},

journal = {Rev Esp Salud Publica},

volume = {95},

abstract = {OBJECTIVE: The European Commission recommends ensuring equity in cancer screening. The aim of this study was to find out if there were inequalities in access to cancer screening programmes in Spain.nnMETHODS: A transversal study was carried out by means of a survey addressed to the people responsible for breast, colorectal (CRC) and cervical cancer screening programmes in the 19 Autonomous Communities (AC) of Spain in 2013 and 2020. Information was collected on organizational characteristics, inequalities in access and interventions to reduce them. A descriptive analysis was made by AC and time period, by calculating frequencies and percentages, depending on the type of programme (breast, CRC and cervix).nnRESULTS: In 2013, 14 ACs participated for the breast programme, 8 for the CRC and 7 for the cervical programme; and in 2020, 14, 13 and 11 ACs respectively. All breast programmes were population-based in both periods (14/14 in 2013 and 14/14 in 2020), as well as CRC ones (8/8 in 2013 and 13/13 in 2020), with an increase in cervical cancer programmes (0/7 en 2013 y 6/11 en 2020). In both periods, social groups not included in the target population and groups that were less involved were identified, with differences according to the type of programme. A total of 53 interventions were carried out to reduce inequalities in access (27 in breast, 22 in RCC and 4 in cervical), 66% of them aimed at specific social groups (35/53).nnCONCLUSIONS: Inequalities in access to cancer screening programmes in Spain are identified, as well as interventions to reduce them.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid29579014,

title = {Physical Test to Estimate Suitable Workloads for an Exercise Program in Breast Cancer Survivors},

author = {Guillamó E and Travier N and Oviedo GR and Fonseca-Nunes A and Alamo JM and Cos F and Roca A and Niño O and Agudo A and Javierre C},

doi = {10.1519/JSC.0000000000002337},

issn = {1533-4287},

year  = {2020},

date = {2020-12-01},

journal = {J Strength Cond Res},

volume = {34},

number = {12},

pages = {3593--3599},

abstract = {Guillamó, E, Travier, N, Oviedo, GR, Fonseca-Nunes, A, Alamo, JM, Cos, F, Roca, A, Niño, O, Agudo, A, and Javierre, C. Physical test to estimate suitable workloads for an exercise program in breast cancer survivors. J Strength Cond Res 34(12): 3593-3599, 2020-Epidemiologic studies suggest that patients with breast cancer who gain weight after diagnosis have a higher risk of recurrence and death. Regular physical exercise can help minimize postdiagnosis weight gain. The objective of the study was to assess the effectiveness of a physical test for individualizing the workloads used during a fitness program. To continuously individualize the intensity of the training, a test was designed and integrated into the sessions. The test consisted in monitoring heart rate and workload during 2 bouts of cycling at moderate intensity. The workload parameters recorded during the tests were later used as reference values to plan the intensity of the next in-person training sessions. The 5 tests conducted during the 12 weeks of the intervention showed significant differences in intensity (F = 3.034, p = 0.047). Compared with the first evaluation, the intensities measured during the third, fourth, and fifth tests presented increases of 9.9% (p = 0.02), 13.2% (p = 0.019), and 17.5% (p = 0.002), respectively. A significant increase in workload with respect to body weight was observed in the physical assessment performed after the program (t = 13.2, p = 0.0001). The peak oxygen consumption with respect to body weight (peak V[Combining Dot Above]O2) achieved by the subjects during the assessment at the end of the program had also increased (t = 9.72, p = 0.0001). The intensity test, introduced in the training sessions along with the physical exercise program, was an easy-to-use, practical tool for monitoring intensity. It allows an adjustment of the workload over the program period that respects the individual progression of each patient.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid33023825,

title = {Differences in breast cancer risk after benign breast disease by type of screening diagnosis},

author = {Louro J and Román M and Posso M and Comerma L and Vidal C and Saladié F and Alcantara R and Sanchez M and Quintana MJ and Del Riego J and Ferrer J and Peñalva L and Bargalló X and Prieto M and Sala M and Castells X},

doi = {10.1016/j.breast.2020.09.005},

issn = {1532-3080},

year  = {2020},

date = {2020-12-01},

journal = {Breast},

volume = {54},

pages = {343--348},

abstract = {INTRODUCTION: We aimed to assess differences in breast cancer risk across benign breast disease diagnosed at prevalent or incident screens.nnMATERIALS AND METHODS: We conducted a retrospective cohort study with data from 629,087 women participating in a long-standing population-based breast cancer screening program in Spain. Each benign breast disease was classified as non-proliferative, proliferative without atypia, or proliferative with atypia, and whether it was diagnosed in a prevalent or incident screen. We used partly conditional Cox hazard regression to estimate the adjusted hazard ratios of the risk of breast cancer.nnRESULTS: Compared with women without benign breast disease, the risk of breast cancer was significantly higher (p-value = 0.005) in women with benign breast disease diagnosed in an incident screen (aHR, 2.67; 95%CI: 2.24-3.19) than in those with benign breast disease diagnosed in a prevalent screen (aHR, 1.87; 95%CI: 1.57-2.24). The highest risk was found in women with a proliferative benign breast disease with atypia (aHR, 4.35; 95%CI: 2.09-9.08, and 3.35; 95%CI: 1.51-7.40 for those diagnosed at incident and prevalent screens, respectively), while the lowest was found in women with non-proliferative benign breast disease (aHR, 2.39; 95%CI: 1.95-2.93, and 1.63; 95%CI: 1.32-2.02 for those diagnosed at incident and prevalent screens, respectively).nnCONCLUSION: Our study showed that the risk of breast cancer conferred by a benign breast disease differed according to type of screen (prevalent or incident). To our knowledge, this is the first study to analyse the impact of the screening type on benign breast disease prognosis.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid32034515,

title = {An exploratory study in breast cancer of factors involved in the use and communication with health professionals of Internet information},

author = {Ochoa-Arnedo C and Flix-Valle A and Casellas-Grau A and Casanovas-Aljaro N and Herrero O and Sumalla EC and de Frutos ML and Sirgo A and Rodríguez A and Campos G and Valverde Y and Travier N and Medina JC},

doi = {10.1007/s00520-020-05335-x},

issn = {1433-7339},

year  = {2020},

date = {2020-10-01},

journal = {Support Care Cancer},

volume = {28},

number = {10},

pages = {4989--4996},

abstract = {OBJECTIVE: To study the impact of the spontaneous use of Internet on breast cancer patients and on their relationship with health professionals.nnMETHODS: A mixed methodology was used. Two questionnaires were designed through three focus groups, and then administered to 186 patients and 59 professionals in order to assess: (1) patients' use of Internet for health-related information and (2) the impact of this information on patients' psychological outcomes and on their relationship with professionals.nnRESULTS: Patients spent more time looking for illness-related information after diagnosis, using interactive communities more than static information websites. Patients and professionals disagreed about the use of Internet in terms of the knowledge it provides, and its psychological impact. The main barrier reported by patients regarding the sharing of online information with their professionals was the belief that it would damage their relationship.nnCONCLUSIONS: Both professionals and patients have a protectionist conception of the therapeutic relationship. This attitude tends to dismiss the positive impact that the use of Internet and the new communication tools may have in cancer patients. New resources should provide an "Internet Prescription" and modes of interaction to facilitate a more open digital communication.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid32753002,

title = {Recent trends in sexually transmitted infections among adolescents, Catalonia, Spain, 2012-2017},

author = {Vives N and Garcia de Olalla P and González V and Barrabeig I and Clotet L and Danés M and Borrell N and Casabona J and Catalan HIV and STI Surveillance Group},

doi = {10.1177/0956462420940911},

issn = {1758-1052},

year  = {2020},

date = {2020-10-01},

journal = {Int J STD AIDS},

volume = {31},

number = {11},

pages = {1047--1054},

abstract = {Monitoring sexually transmitted infections (STIs) in adolescents is essential to inform STI prevention strategies at primary and secondary levels in this key population. We aim to describe recent trends in STIs among adolescents and to analyse their socio-demographic and behavioural characteristics in Catalonia, Spain between 2012 and 2017. Data on  (CT) infection, gonorrhoea and syphilis cases aged from 13 to 19 years reported to the Catalan Mandatory Notifiable System from 2012 to 2017 were analysed. Diagnosis rates were calculated and a descriptive analysis was performed. Between 2012 and 2017, CT infection, gonorrhoea and syphilis cases reported among adolescents aged 13-19 years accounted for more than one-eleventh of all reported cases in Catalonia. The rate of the three nationally-notifiable STIs increased dramatically among adolescents. CT infection rates rose from 13 to 144.1 per 100,000 adolescents between 2012 and 2017, an increase of 1007%; gonorrhoea cases increased by 246% (from 13.4 to 45.4/100,000) and syphilis cases increased by 247% (from 1.7 to 5.9/100,000). Gonorrhoea and syphilis cases affected mainly males while CT infection cases were mostly in females (84%). Adolescents are being increasingly affected by CT infection, gonorrhoea and syphilis. A broader array of intervention strategies aimed at adolescents should be reinforced through strong prevention campaigns, improved sexual health information, as well as encouragement of regular offers of STI screening by healthcare providers.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid33036599,

title = {The role of socio-demographic determinants in the geo-spatial distribution of newly diagnosed HIV infections in small areas of Catalonia (Spain)},

author = {Agustí C and Font-Casaseca N and Belvis F and Julià M and Vives N and Montoliu A and Pericàs JM and Casabona J and Benach J},

doi = {10.1186/s12889-020-09603-7},

issn = {1471-2458},

year  = {2020},

date = {2020-10-01},

journal = {BMC Public Health},

volume = {20},

number = {1},

pages = {1533},

abstract = {BACKGROUND: Spatial visualization of HIV surveillance data could improve the planning of programs to address the HIV epidemic. The objectives of the study were to describe the characteristics and the spatial distribution of newly diagnosed HIV infection in Catalonia and to identify factors associated with HIV infection rates.nnMETHODS: Surveillance data from the national registry were presented in the form of descriptive and ring maps and used to study the spatial distribution of new HIV diagnoses in Catalonia (2012-2016) and associated risk factors at the small area level (ABS, acronym for "basic health area" in Catalan). Incident cases were modeled using the following as predictors: type of municipality, prevalence of young men and migrant groups, GBMSM activity indicators, and other variables at the aggregated level.nnRESULTS: New HIV diagnoses are heterogeneously distributed across Catalonia. The predictors that proved to be significantly associated with a higher rate of new HIV diagnoses were ABS located in the city of Barcelona (IRR, 2.520; P < 0.001), a higher proportion of men aged 15-44 years (IRR, 1.193; P = 0.003), a higher proportion of GBMSM (IRR, 1.230; P = 0.030), a higher proportion of men from Western Europe (IRR, 1.281; P = 0.003), a higher proportion of men from Latin America (IRR, 1.260; P = 0.003), and a higher number of gay locations (IRR, 2.665; P < 0.001). No association was observed between the HIV diagnosis rate and economic deprivation.nnCONCLUSIONS: Ring maps revealed substantial spatial associations for the rate of new HIV diagnoses. New HIV diagnoses are concentrated in ABS located in urban areas. Our results show that, in the case of HIV infection, the socioeconomic deprivation index on which the Catalan government bases its budget allocation policies among the ABS should not be the only criterion used.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid31629546,

title = {Estimation of the Risk of Lung Cancer in Women Participating in a Population-Based Breast Cancer Screening Program},

author = {González-Marrón A and Martín-Sánchez JC and Garcia-Alemany F and Martínez-Martín E and Matilla-Santander N and Cartanyà-Hueso À and Vidal C and García M and Martínez-Sánchez JM},

doi = {10.1016/j.arbres.2019.04.014},

issn = {2173-5751},

year  = {2020},

date = {2020-05-01},

journal = {Arch Bronconeumol (Engl Ed)},

volume = {56},

number = {5},

pages = {277--281},

abstract = {INTRODUCTION: Lung cancer mortality is increasing in women. In Spain, estimates suggest that lung cancer mortality may soon surpass breast cancer mortality, the main cause of cancer mortality among women. The aim of this study was to estimate the proportion of women at high risk of developing lung cancer in a group of participants in a population-based breast cancer screening program.nnMETHODS: Cross-sectional study in a sample of women who participated in a population-based breast cancer screening program in 2016 in Hospitalet de Llobregat (n=1,601). High risk of lung cancer was defined according to the criteria of the National Lung Screening Trial (NLST) and the Dutch-Belgian randomized lung cancer screening trial (NELSON).nnRESULTS: Around 20% of smokers according to NLST criteria and 40% of smokers according to NELSON criteria, and around 20% of former smokers according to both criteria, are at high risk of developing lung cancer. A positive and statistically significant trend is observed between the proportion of women at high risk and nicotine dependence measured with the brief Fagerström test.nnCONCLUSIONS: A high proportion of participants in this breast cancer screening program have a high risk of developing lung cancer and would be eligible to participate in a lung cancer screening program. Population-based breast cancer screening programs may be useful to implement lung cancer primary prevention activities.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}