Previous projects
Cost-effectiveness and budgetary impact of three preventive strategies in lung cancer
The prevalence of smoking in Spain is decreasing; however, both the incidence and mortality from lung cancer are increasing alarmingly among women and the trend is expected to continue to increase if no intervention is made. In a general context of expenditure containment, health interventions must not only be evaluated in terms of impact on health or in economic terms, but also in terms of efficiency.
– Define and estimate the Spanish population at high risk of developing lung cancer.
– Determine the proportion of the population treated in Primary Care with a high risk of developing lung cancer.
– Conduct an economic evaluation comparing the implementation of three preventive strategies in lung cancer with a non-intervention scenario, from the perspective of the National Health System (NHS) and from a social perspective. A cost-utility analysis is contemplated to measure the health benefit as quality-adjusted life years gained, and a cost-effectiveness analysis to measure the health benefit as avoidable deaths from lung cancer.
– Analyze the budgetary impact of the implementation of three preventive strategies for lung cancer in the NHS.
Objective 1: Data from the Spanish National Health Survey (ENSE) 2011-12 are used. The population at risk is described throughout the Spanish territory and stratified by sex and by autonomous community.
Objective 2: The electronic medical record of Primary Care is explored. The assigned population and the population served in the Barcelona Health Region are selected considering two age groups: 35-49 years (potentially at risk) and 50-75 years (high risk). The results are compared with the theoretical proportion obtained with the ENSE and confidence intervals of proportions are calculated to estimate statistically significant differences between both groups.
Objective 3: A hypothetical cohort with the characteristics of the adult population at high risk of developing lung cancer and the population potentially at risk is studied using data from the ENSE 2011-12. Primary and secondary prevention interventions applied to high-risk and potentially at-risk population groups are combined: brief intervention to quit smoking, intensive treatment to quit smoking and organized screening. To determine the effectiveness of each of the interventions, a systematic review of the literature is carried out to obtain different percentages of cessation of consumption. The baseline scenario (no intervention) is compared with three preventive strategies, which combine primary and secondary prevention interventions applied to both population groups.
Objective 4: The population at risk calculated from the ENSE 2011-12 is considered. Two scenarios are estimated and compared, the current scenario and new hypothetical scenarios derived from the introduction of the different strategies, considering different percentages of implementation of the interventions.
1 year, extended for 6 months (January 2017 to June 2018).
Grants for cancer research projects, Spanish Association Against Cancer (€35,000).
Lucia Benito (ICO-IDIBELL)
Gemma Binefa (ICO-IDIBELL)
Mercy Carles (URV)
Julieta Corral (ICO-IDIBELL)
Mireia Díaz (ICO-IDIBELL)
Esteve Fernández (ICO-IDIBELL)
Marcela Fu (IP, ICO-IDIBELL)
Montse García (IP, ICO-IDIBELL)
Carlos Martín (CAP Passeig de Sant Joan)
Amparo Romaguera (ICO)
Albert Santiago (ICO-IDIBELL)
Carmen Vidal (ICO-IDIBELL)
Montserrat Rué (IRB Lleida)
Marta Trapero-Bertran (UIC)
1: Fu M, Travier N, Martín-Sánchez JC, Martínez-Sánchez JM, Vidal C, Garcia M; LUCAPREV research group. Identifying high-risk individuals for lung cancer screening: Going beyond NLST criteria. PLoS One. 2018;13(4):e0195441. doi: 10.1371/journal.pone.0195441. PMID: 29621354; PMCID: PMC5886563.
2: Travier N, Fu M, Romaguera A, Martín-Cantera C, Fernández E, Vidal C, Garcia M; LUCAPREV research group. 6-Year Risk of Developing Lung Cancer in Spain: Analysis by Autonomous Communities. Arch Bronchopneumol. 2021;57(8):521-7. doi: 10.1016/j.arbres.2020.03.022. PMID: 32402549.
3: Diaz M, Garcia M, Vidal C, Santiago A, Gnutti G, Gómez D, Trapero-Bertran M, Fu M; Lung Cancer Prevention LUCAPREV research group. Health and economic impact at a population level of both primary and secondary preventive lung cancer interventions: A model-based cost-effectiveness analysis. Lung Cancer. 2021;159:153-161. doi: 10.1016/j.lungcan.2021.06.027. PMID: 34352591.
Travier publication podcast: https://multimedia.elsevier.es/PublicationsMultimediaV1/item/multimedia/stream/S0300289620301034:mmc1.mp3?idApp=UINPBA00003Z
Poster communication: Santiago A, Fu M, Vidal C, Trapero M, Garcia M, Díaz M. Mathematical simulation model to evaluate lung cancer prevention strategies. MESIO UPC-UB R+D Conference, 9 May 2018.
Oral communication: Santiago-Boíl A, Fu M, Vidal C, Garcia M, Díaz M. Cost-effectiveness analysis of lung cancer prevention strategies. XXXVIII Conference on Health Economics; Las Palmas de Gran Canaria, 20-22 June 2018.
Oral communication: Santiago-Boíl A, Fu M, Vidal C, Garcia M, Díaz M. Cost-effectiveness analyzes of lung cancer prevention strategies. XXIX International Biometric Conference; Barcelona, 8-13 July 2018.
Oral communication: Vidal C, Fu M, Travier N, García M. Lung cancer risk stratification in the Spanish population. Implications for prevention. XXXVI Annual Meeting of the Spanish Society of Epidemiology (SEE) and XIII Congress of the Portuguese Association of Epidemiology (APE), Lisbon, 11-14 September 2018.
Poster communication Garcia M, Fu M, Travier N, Vidal C. Identifying high-risk individuals for lung cancer screening–going beyond NELSON and NLST eligibility criteria. International Cancer Screening Network Conference, Rotterdam, 3-5 June 2019.
Oral communication: Garcia M, Vidal C, Santiago A, Fu M, Rue M, Carles-Lavila M, Trapero-Bertran M, Díaz M, Lung Cancer Prevention research group. A cost-effectiveness analysis of lung cancer prevention strategies at population level combining smoking cessation interventions and early detection with low-dose computed tomography in Spain. International Cancer Screening Conference, Rotterdam, 3-5 June 2019.
Díaz M, García M, Vidal C, Santiago A, Rue M, Carles-Lavila M, Trapero-Bertran M, Fu M, Grupo de trabajo LUCAPREV. Cost-effectiveness analysis of lung cancer preventive strategies in Spain. XXXVII Annual Meeting of the Spanish Society of Epidemiology (SEE), XIV Congress of the Portuguese Association of Epidemiology (APE) and XVIII Congress of the Spanish Society of Public Health and Health Administration (SESPAS), Oviedo, September 3-6, 2019.
Title: Lung Cancer Model for Evaluating Cancer Control Interventions.
Student: Albert Santiago Boíl.
Director: Mireia Díaz Sanchis.
Co-Director: Klaus Gerhard Langohr.
Program: Master of Science in Advanced Mathematics and Mathematical Engineering
Centre: Department of Statistics and Operational Research, UPC
Defense date: May 16, 2018.2019.